Mapping the biosynthetic pathway of a hybrid polyketide-nonribosomal peptide in a metazoan

The only known animal polyketide-nonribosomal peptides, the nemamides, are biosynthesized by two megasynthetases in the canal-associated neurons (CANs) of C. elegans. Here, the authors map the biosynthetic roles of individual megasynthetase domains and identify additional enzymes in the CANs require...

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Auteurs principaux:	Likui Feng, Matthew T. Gordon, Ying Liu, Kari B. Basso, Rebecca A. Butcher
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/158ad176f5144f99a8a641b1a5b62a82
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spelling	oai:doaj.org-article:158ad176f5144f99a8a641b1a5b62a822021-12-02T18:50:56ZMapping the biosynthetic pathway of a hybrid polyketide-nonribosomal peptide in a metazoan10.1038/s41467-021-24682-92041-1723https://doaj.org/article/158ad176f5144f99a8a641b1a5b62a822021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24682-9https://doaj.org/toc/2041-1723The only known animal polyketide-nonribosomal peptides, the nemamides, are biosynthesized by two megasynthetases in the canal-associated neurons (CANs) of C. elegans. Here, the authors map the biosynthetic roles of individual megasynthetase domains and identify additional enzymes in the CANs required for nemamide biosynthesis.Likui FengMatthew T. GordonYing LiuKari B. BassoRebecca A. ButcherNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Likui Feng Matthew T. Gordon Ying Liu Kari B. Basso Rebecca A. Butcher Mapping the biosynthetic pathway of a hybrid polyketide-nonribosomal peptide in a metazoan
description	The only known animal polyketide-nonribosomal peptides, the nemamides, are biosynthesized by two megasynthetases in the canal-associated neurons (CANs) of C. elegans. Here, the authors map the biosynthetic roles of individual megasynthetase domains and identify additional enzymes in the CANs required for nemamide biosynthesis.
format	article
author	Likui Feng Matthew T. Gordon Ying Liu Kari B. Basso Rebecca A. Butcher
author_facet	Likui Feng Matthew T. Gordon Ying Liu Kari B. Basso Rebecca A. Butcher
author_sort	Likui Feng
title	Mapping the biosynthetic pathway of a hybrid polyketide-nonribosomal peptide in a metazoan
title_short	Mapping the biosynthetic pathway of a hybrid polyketide-nonribosomal peptide in a metazoan
title_full	Mapping the biosynthetic pathway of a hybrid polyketide-nonribosomal peptide in a metazoan
title_fullStr	Mapping the biosynthetic pathway of a hybrid polyketide-nonribosomal peptide in a metazoan
title_full_unstemmed	Mapping the biosynthetic pathway of a hybrid polyketide-nonribosomal peptide in a metazoan
title_sort	mapping the biosynthetic pathway of a hybrid polyketide-nonribosomal peptide in a metazoan
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/158ad176f5144f99a8a641b1a5b62a82
work_keys_str_mv	AT likuifeng mappingthebiosyntheticpathwayofahybridpolyketidenonribosomalpeptideinametazoan AT matthewtgordon mappingthebiosyntheticpathwayofahybridpolyketidenonribosomalpeptideinametazoan AT yingliu mappingthebiosyntheticpathwayofahybridpolyketidenonribosomalpeptideinametazoan AT karibbasso mappingthebiosyntheticpathwayofahybridpolyketidenonribosomalpeptideinametazoan AT rebeccaabutcher mappingthebiosyntheticpathwayofahybridpolyketidenonribosomalpeptideinametazoan
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Mapping the biosynthetic pathway of a hybrid polyketide-nonribosomal peptide in a metazoan

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