Mapping the biosynthetic pathway of a hybrid polyketide-nonribosomal peptide in a metazoan

The only known animal polyketide-nonribosomal peptides, the nemamides, are biosynthesized by two megasynthetases in the canal-associated neurons (CANs) of C. elegans. Here, the authors map the biosynthetic roles of individual megasynthetase domains and identify additional enzymes in the CANs require...

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Autores principales: Likui Feng, Matthew T. Gordon, Ying Liu, Kari B. Basso, Rebecca A. Butcher
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/158ad176f5144f99a8a641b1a5b62a82
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