Dual-mechanism based CTLs infiltration enhancement initiated by Nano-sapper potentiates immunotherapy against immune-excluded tumors

The exclusion of cytotoxic T cells remains an important barrier to the efficacy of immunotherapies. Here the authors demonstrate that the combination anti-fibrosis agents and immune-enhanced cytokines can enhance T cell infiltration in a mouse model of pancreatic cancer.

Guardado en:

Detalles Bibliográficos
Autores principales:	Yukun Huang, Yu Chen, Songlei Zhou, Liang Chen, Jiahao Wang, Yuanyuan Pei, Minjun Xu, Jingxian Feng, Tianze Jiang, Kaifan Liang, Shanshan Liu, Qingxiang Song, Gan Jiang, Xiao Gu, Qian Zhang, Xiaoling Gao, Jun Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/158cb6f07ed24ee38767bf2374a587c5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:158cb6f07ed24ee38767bf2374a587c5
record_format	dspace
spelling	oai:doaj.org-article:158cb6f07ed24ee38767bf2374a587c52021-12-02T14:42:15ZDual-mechanism based CTLs infiltration enhancement initiated by Nano-sapper potentiates immunotherapy against immune-excluded tumors10.1038/s41467-020-14425-72041-1723https://doaj.org/article/158cb6f07ed24ee38767bf2374a587c52020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14425-7https://doaj.org/toc/2041-1723The exclusion of cytotoxic T cells remains an important barrier to the efficacy of immunotherapies. Here the authors demonstrate that the combination anti-fibrosis agents and immune-enhanced cytokines can enhance T cell infiltration in a mouse model of pancreatic cancer.Yukun HuangYu ChenSonglei ZhouLiang ChenJiahao WangYuanyuan PeiMinjun XuJingxian FengTianze JiangKaifan LiangShanshan LiuQingxiang SongGan JiangXiao GuQian ZhangXiaoling GaoJun ChenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yukun Huang Yu Chen Songlei Zhou Liang Chen Jiahao Wang Yuanyuan Pei Minjun Xu Jingxian Feng Tianze Jiang Kaifan Liang Shanshan Liu Qingxiang Song Gan Jiang Xiao Gu Qian Zhang Xiaoling Gao Jun Chen Dual-mechanism based CTLs infiltration enhancement initiated by Nano-sapper potentiates immunotherapy against immune-excluded tumors
description	The exclusion of cytotoxic T cells remains an important barrier to the efficacy of immunotherapies. Here the authors demonstrate that the combination anti-fibrosis agents and immune-enhanced cytokines can enhance T cell infiltration in a mouse model of pancreatic cancer.
format	article
author	Yukun Huang Yu Chen Songlei Zhou Liang Chen Jiahao Wang Yuanyuan Pei Minjun Xu Jingxian Feng Tianze Jiang Kaifan Liang Shanshan Liu Qingxiang Song Gan Jiang Xiao Gu Qian Zhang Xiaoling Gao Jun Chen
author_facet	Yukun Huang Yu Chen Songlei Zhou Liang Chen Jiahao Wang Yuanyuan Pei Minjun Xu Jingxian Feng Tianze Jiang Kaifan Liang Shanshan Liu Qingxiang Song Gan Jiang Xiao Gu Qian Zhang Xiaoling Gao Jun Chen
author_sort	Yukun Huang
title	Dual-mechanism based CTLs infiltration enhancement initiated by Nano-sapper potentiates immunotherapy against immune-excluded tumors
title_short	Dual-mechanism based CTLs infiltration enhancement initiated by Nano-sapper potentiates immunotherapy against immune-excluded tumors
title_full	Dual-mechanism based CTLs infiltration enhancement initiated by Nano-sapper potentiates immunotherapy against immune-excluded tumors
title_fullStr	Dual-mechanism based CTLs infiltration enhancement initiated by Nano-sapper potentiates immunotherapy against immune-excluded tumors
title_full_unstemmed	Dual-mechanism based CTLs infiltration enhancement initiated by Nano-sapper potentiates immunotherapy against immune-excluded tumors
title_sort	dual-mechanism based ctls infiltration enhancement initiated by nano-sapper potentiates immunotherapy against immune-excluded tumors
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/158cb6f07ed24ee38767bf2374a587c5
work_keys_str_mv	AT yukunhuang dualmechanismbasedctlsinfiltrationenhancementinitiatedbynanosapperpotentiatesimmunotherapyagainstimmuneexcludedtumors AT yuchen dualmechanismbasedctlsinfiltrationenhancementinitiatedbynanosapperpotentiatesimmunotherapyagainstimmuneexcludedtumors AT songleizhou dualmechanismbasedctlsinfiltrationenhancementinitiatedbynanosapperpotentiatesimmunotherapyagainstimmuneexcludedtumors AT liangchen dualmechanismbasedctlsinfiltrationenhancementinitiatedbynanosapperpotentiatesimmunotherapyagainstimmuneexcludedtumors AT jiahaowang dualmechanismbasedctlsinfiltrationenhancementinitiatedbynanosapperpotentiatesimmunotherapyagainstimmuneexcludedtumors AT yuanyuanpei dualmechanismbasedctlsinfiltrationenhancementinitiatedbynanosapperpotentiatesimmunotherapyagainstimmuneexcludedtumors AT minjunxu dualmechanismbasedctlsinfiltrationenhancementinitiatedbynanosapperpotentiatesimmunotherapyagainstimmuneexcludedtumors AT jingxianfeng dualmechanismbasedctlsinfiltrationenhancementinitiatedbynanosapperpotentiatesimmunotherapyagainstimmuneexcludedtumors AT tianzejiang dualmechanismbasedctlsinfiltrationenhancementinitiatedbynanosapperpotentiatesimmunotherapyagainstimmuneexcludedtumors AT kaifanliang dualmechanismbasedctlsinfiltrationenhancementinitiatedbynanosapperpotentiatesimmunotherapyagainstimmuneexcludedtumors AT shanshanliu dualmechanismbasedctlsinfiltrationenhancementinitiatedbynanosapperpotentiatesimmunotherapyagainstimmuneexcludedtumors AT qingxiangsong dualmechanismbasedctlsinfiltrationenhancementinitiatedbynanosapperpotentiatesimmunotherapyagainstimmuneexcludedtumors AT ganjiang dualmechanismbasedctlsinfiltrationenhancementinitiatedbynanosapperpotentiatesimmunotherapyagainstimmuneexcludedtumors AT xiaogu dualmechanismbasedctlsinfiltrationenhancementinitiatedbynanosapperpotentiatesimmunotherapyagainstimmuneexcludedtumors AT qianzhang dualmechanismbasedctlsinfiltrationenhancementinitiatedbynanosapperpotentiatesimmunotherapyagainstimmuneexcludedtumors AT xiaolinggao dualmechanismbasedctlsinfiltrationenhancementinitiatedbynanosapperpotentiatesimmunotherapyagainstimmuneexcludedtumors AT junchen dualmechanismbasedctlsinfiltrationenhancementinitiatedbynanosapperpotentiatesimmunotherapyagainstimmuneexcludedtumors
_version_	1718389736465235968

Dual-mechanism based CTLs infiltration enhancement initiated by Nano-sapper potentiates immunotherapy against immune-excluded tumors

Ejemplares similares