Neutrophil activation and NETosis are the major drivers of thrombosis in heparin-induced thrombocytopenia

The pathogenesis of heparin-induced thrombocytopenia and thrombosis (HIT) is mediated by heparin-reactive autoantibodies binding to platelets (thrombocytes). Here the authors show neutrophil activation and NETosis are elevated in patients with HIT, and are essential for thrombosis in HIT mouse model...

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Autores principales:	José Perdomo, Halina H. L. Leung, Zohra Ahmadi, Feng Yan, James J. H. Chong, Freda H. Passam, Beng H. Chong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/15928141dfc447cb9a207a9ee46269e1
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spelling	oai:doaj.org-article:15928141dfc447cb9a207a9ee46269e12021-12-02T17:01:50ZNeutrophil activation and NETosis are the major drivers of thrombosis in heparin-induced thrombocytopenia10.1038/s41467-019-09160-72041-1723https://doaj.org/article/15928141dfc447cb9a207a9ee46269e12019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09160-7https://doaj.org/toc/2041-1723The pathogenesis of heparin-induced thrombocytopenia and thrombosis (HIT) is mediated by heparin-reactive autoantibodies binding to platelets (thrombocytes). Here the authors show neutrophil activation and NETosis are elevated in patients with HIT, and are essential for thrombosis in HIT mouse models.José PerdomoHalina H. L. LeungZohra AhmadiFeng YanJames J. H. ChongFreda H. PassamBeng H. ChongNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q José Perdomo Halina H. L. Leung Zohra Ahmadi Feng Yan James J. H. Chong Freda H. Passam Beng H. Chong Neutrophil activation and NETosis are the major drivers of thrombosis in heparin-induced thrombocytopenia
description	The pathogenesis of heparin-induced thrombocytopenia and thrombosis (HIT) is mediated by heparin-reactive autoantibodies binding to platelets (thrombocytes). Here the authors show neutrophil activation and NETosis are elevated in patients with HIT, and are essential for thrombosis in HIT mouse models.
format	article
author	José Perdomo Halina H. L. Leung Zohra Ahmadi Feng Yan James J. H. Chong Freda H. Passam Beng H. Chong
author_facet	José Perdomo Halina H. L. Leung Zohra Ahmadi Feng Yan James J. H. Chong Freda H. Passam Beng H. Chong
author_sort	José Perdomo
title	Neutrophil activation and NETosis are the major drivers of thrombosis in heparin-induced thrombocytopenia
title_short	Neutrophil activation and NETosis are the major drivers of thrombosis in heparin-induced thrombocytopenia
title_full	Neutrophil activation and NETosis are the major drivers of thrombosis in heparin-induced thrombocytopenia
title_fullStr	Neutrophil activation and NETosis are the major drivers of thrombosis in heparin-induced thrombocytopenia
title_full_unstemmed	Neutrophil activation and NETosis are the major drivers of thrombosis in heparin-induced thrombocytopenia
title_sort	neutrophil activation and netosis are the major drivers of thrombosis in heparin-induced thrombocytopenia
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/15928141dfc447cb9a207a9ee46269e1
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Neutrophil activation and NETosis are the major drivers of thrombosis in heparin-induced thrombocytopenia

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