Instrumental variable estimation for a time-varying treatment and a time-to-event outcome via structural nested cumulative failure time models

Abstract Background In many applications of instrumental variable (IV) methods, the treatments of interest are intrinsically time-varying and outcomes of interest are failure time outcomes. A common example is Mendelian randomization (MR), which uses genetic variants as proposed IVs. In this article...

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Autores principales: Joy Shi, Sonja A. Swanson, Peter Kraft, Bernard Rosner, Immaculata De Vivo, Miguel A. Hernán
Formato: article
Lenguaje:EN
Publicado: BMC 2021
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Acceso en línea:https://doaj.org/article/15930bd45cd94f2cac6994e68340dfff
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