Heteroresistance to beta-lactam antibiotics may often be a stage in the progression to antibiotic resistance.

Antibiotic resistance is a growing crisis that threatens many aspects of modern healthcare. Dogma is that resistance often develops due to acquisition of a resistance gene or mutation and that when this occurs, all the cells in the bacterial population are phenotypically resistant. In contrast, hete...

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Autores principales:	Victor I Band, David S Weiss
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/159cd3d2f31b4f95a32926daa004fd79
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spelling	oai:doaj.org-article:159cd3d2f31b4f95a32926daa004fd792021-12-02T19:54:22ZHeteroresistance to beta-lactam antibiotics may often be a stage in the progression to antibiotic resistance.1544-91731545-788510.1371/journal.pbio.3001346https://doaj.org/article/159cd3d2f31b4f95a32926daa004fd792021-07-01T00:00:00Zhttps://doi.org/10.1371/journal.pbio.3001346https://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Antibiotic resistance is a growing crisis that threatens many aspects of modern healthcare. Dogma is that resistance often develops due to acquisition of a resistance gene or mutation and that when this occurs, all the cells in the bacterial population are phenotypically resistant. In contrast, heteroresistance (HR) is a form of antibiotic resistance where only a subset of cells within a bacterial population are resistant to a given drug. These resistant cells can rapidly replicate in the presence of the antibiotic and cause treatment failures. If and how HR and resistance are related is unclear. Using carbapenem-resistant Enterobacterales (CRE), we provide evidence that HR to beta-lactams develops over years of antibiotic usage and that it is gradually supplanted by resistance. This suggests the possibility that HR may often develop before resistance and frequently be a stage in its progression, potentially representing a major shift in our understanding of the evolution of antibiotic resistance.Victor I BandDavid S WeissPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 19, Iss 7, p e3001346 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Victor I Band David S Weiss Heteroresistance to beta-lactam antibiotics may often be a stage in the progression to antibiotic resistance.
description	Antibiotic resistance is a growing crisis that threatens many aspects of modern healthcare. Dogma is that resistance often develops due to acquisition of a resistance gene or mutation and that when this occurs, all the cells in the bacterial population are phenotypically resistant. In contrast, heteroresistance (HR) is a form of antibiotic resistance where only a subset of cells within a bacterial population are resistant to a given drug. These resistant cells can rapidly replicate in the presence of the antibiotic and cause treatment failures. If and how HR and resistance are related is unclear. Using carbapenem-resistant Enterobacterales (CRE), we provide evidence that HR to beta-lactams develops over years of antibiotic usage and that it is gradually supplanted by resistance. This suggests the possibility that HR may often develop before resistance and frequently be a stage in its progression, potentially representing a major shift in our understanding of the evolution of antibiotic resistance.
format	article
author	Victor I Band David S Weiss
author_facet	Victor I Band David S Weiss
author_sort	Victor I Band
title	Heteroresistance to beta-lactam antibiotics may often be a stage in the progression to antibiotic resistance.
title_short	Heteroresistance to beta-lactam antibiotics may often be a stage in the progression to antibiotic resistance.
title_full	Heteroresistance to beta-lactam antibiotics may often be a stage in the progression to antibiotic resistance.
title_fullStr	Heteroresistance to beta-lactam antibiotics may often be a stage in the progression to antibiotic resistance.
title_full_unstemmed	Heteroresistance to beta-lactam antibiotics may often be a stage in the progression to antibiotic resistance.
title_sort	heteroresistance to beta-lactam antibiotics may often be a stage in the progression to antibiotic resistance.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/159cd3d2f31b4f95a32926daa004fd79
work_keys_str_mv	AT victoriband heteroresistancetobetalactamantibioticsmayoftenbeastageintheprogressiontoantibioticresistance AT davidsweiss heteroresistancetobetalactamantibioticsmayoftenbeastageintheprogressiontoantibioticresistance
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Heteroresistance to beta-lactam antibiotics may often be a stage in the progression to antibiotic resistance.

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