The Curious Case of Nonrepetitive Centromeric DNA Sequences in <named-content content-type="genus-species">Candida auris</named-content> and Related Species
ABSTRACT 2009 saw the first description of Candida auris, a yeast pathogen of humans. C. auris has since grown into a global problem in intensive care settings, where it causes systemic infections in patients with underlying health issues. Recent whole-genome sequencing has discerned five C. auris c...
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American Society for Microbiology
2021
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oai:doaj.org-article:159e72fd2c534588a0ee5e02d1e38eb82021-11-10T18:37:52ZThe Curious Case of Nonrepetitive Centromeric DNA Sequences in <named-content content-type="genus-species">Candida auris</named-content> and Related Species10.1128/mBio.01476-212150-7511https://doaj.org/article/159e72fd2c534588a0ee5e02d1e38eb82021-08-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01476-21https://doaj.org/toc/2150-7511ABSTRACT 2009 saw the first description of Candida auris, a yeast pathogen of humans. C. auris has since grown into a global problem in intensive care settings, where it causes systemic infections in patients with underlying health issues. Recent whole-genome sequencing has discerned five C. auris clades with distinct phenotypic features which display genomic divergence on a DNA sequence and a chromosome structure level. In the absence of sexual reproduction in C. auris, the mechanism(s) behind the rapid genomic evolution of this emerging killer yeast has remained obscure. Yet, one important bit of information about chromosome organization was missing, the identification of the centromeres. In a recent study, Sanyal and coworkers (A. Narayanan, R. N. Vadnala, P. Ganguly, P. Selvakumar, et al., mBio 12:e00905-21, 2021, https://doi.org/10.1128/mBio.00905-21) filled this knowledge gap by mapping the centromeres in C. auris and its close relatives. This represents a major advance in the chromosome biology of the Candida/Clavispora clade.Alexander LorenzNicolas PaponAmerican Society for MicrobiologyarticleCandida auriscentromereschromosomeskaryotype evolutioncentromereMicrobiologyQR1-502ENmBio, Vol 12, Iss 4 (2021) |
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Candida auris centromeres chromosomes karyotype evolution centromere Microbiology QR1-502 |
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Candida auris centromeres chromosomes karyotype evolution centromere Microbiology QR1-502 Alexander Lorenz Nicolas Papon The Curious Case of Nonrepetitive Centromeric DNA Sequences in <named-content content-type="genus-species">Candida auris</named-content> and Related Species |
| description |
ABSTRACT 2009 saw the first description of Candida auris, a yeast pathogen of humans. C. auris has since grown into a global problem in intensive care settings, where it causes systemic infections in patients with underlying health issues. Recent whole-genome sequencing has discerned five C. auris clades with distinct phenotypic features which display genomic divergence on a DNA sequence and a chromosome structure level. In the absence of sexual reproduction in C. auris, the mechanism(s) behind the rapid genomic evolution of this emerging killer yeast has remained obscure. Yet, one important bit of information about chromosome organization was missing, the identification of the centromeres. In a recent study, Sanyal and coworkers (A. Narayanan, R. N. Vadnala, P. Ganguly, P. Selvakumar, et al., mBio 12:e00905-21, 2021, https://doi.org/10.1128/mBio.00905-21) filled this knowledge gap by mapping the centromeres in C. auris and its close relatives. This represents a major advance in the chromosome biology of the Candida/Clavispora clade. |
| format |
article |
| author |
Alexander Lorenz Nicolas Papon |
| author_facet |
Alexander Lorenz Nicolas Papon |
| author_sort |
Alexander Lorenz |
| title |
The Curious Case of Nonrepetitive Centromeric DNA Sequences in <named-content content-type="genus-species">Candida auris</named-content> and Related Species |
| title_short |
The Curious Case of Nonrepetitive Centromeric DNA Sequences in <named-content content-type="genus-species">Candida auris</named-content> and Related Species |
| title_full |
The Curious Case of Nonrepetitive Centromeric DNA Sequences in <named-content content-type="genus-species">Candida auris</named-content> and Related Species |
| title_fullStr |
The Curious Case of Nonrepetitive Centromeric DNA Sequences in <named-content content-type="genus-species">Candida auris</named-content> and Related Species |
| title_full_unstemmed |
The Curious Case of Nonrepetitive Centromeric DNA Sequences in <named-content content-type="genus-species">Candida auris</named-content> and Related Species |
| title_sort |
curious case of nonrepetitive centromeric dna sequences in <named-content content-type="genus-species">candida auris</named-content> and related species |
| publisher |
American Society for Microbiology |
| publishDate |
2021 |
| url |
https://doaj.org/article/159e72fd2c534588a0ee5e02d1e38eb8 |
| work_keys_str_mv |
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