Surface chemistry-mediated modulation of adsorbed albumin folding state specifies nanocarrier clearance by distinct macrophage subsets

Polymeric nanocarriers used for drug delivery are often coated by albumin in vivo influencing the therapeutic outcomes. Here, the authors engineer the surface chemistry of a nanocarrier to either stabilize or denature the structure of adsorbed albumin, resulting in evasion or clearance by macrophage...

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Autores principales:	Michael P. Vincent, Sharan Bobbala, Nicholas B. Karabin, Molly Frey, Yugang Liu, Justin O. Navidzadeh, Trevor Stack, Evan A. Scott
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/15a179777f9c4b2e8d6492098d24f2b1
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spelling	oai:doaj.org-article:15a179777f9c4b2e8d6492098d24f2b12021-12-02T14:16:13ZSurface chemistry-mediated modulation of adsorbed albumin folding state specifies nanocarrier clearance by distinct macrophage subsets10.1038/s41467-020-20886-72041-1723https://doaj.org/article/15a179777f9c4b2e8d6492098d24f2b12021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20886-7https://doaj.org/toc/2041-1723Polymeric nanocarriers used for drug delivery are often coated by albumin in vivo influencing the therapeutic outcomes. Here, the authors engineer the surface chemistry of a nanocarrier to either stabilize or denature the structure of adsorbed albumin, resulting in evasion or clearance by macrophages.Michael P. VincentSharan BobbalaNicholas B. KarabinMolly FreyYugang LiuJustin O. NavidzadehTrevor StackEvan A. ScottNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael P. Vincent Sharan Bobbala Nicholas B. Karabin Molly Frey Yugang Liu Justin O. Navidzadeh Trevor Stack Evan A. Scott Surface chemistry-mediated modulation of adsorbed albumin folding state specifies nanocarrier clearance by distinct macrophage subsets
description	Polymeric nanocarriers used for drug delivery are often coated by albumin in vivo influencing the therapeutic outcomes. Here, the authors engineer the surface chemistry of a nanocarrier to either stabilize or denature the structure of adsorbed albumin, resulting in evasion or clearance by macrophages.
format	article
author	Michael P. Vincent Sharan Bobbala Nicholas B. Karabin Molly Frey Yugang Liu Justin O. Navidzadeh Trevor Stack Evan A. Scott
author_facet	Michael P. Vincent Sharan Bobbala Nicholas B. Karabin Molly Frey Yugang Liu Justin O. Navidzadeh Trevor Stack Evan A. Scott
author_sort	Michael P. Vincent
title	Surface chemistry-mediated modulation of adsorbed albumin folding state specifies nanocarrier clearance by distinct macrophage subsets
title_short	Surface chemistry-mediated modulation of adsorbed albumin folding state specifies nanocarrier clearance by distinct macrophage subsets
title_full	Surface chemistry-mediated modulation of adsorbed albumin folding state specifies nanocarrier clearance by distinct macrophage subsets
title_fullStr	Surface chemistry-mediated modulation of adsorbed albumin folding state specifies nanocarrier clearance by distinct macrophage subsets
title_full_unstemmed	Surface chemistry-mediated modulation of adsorbed albumin folding state specifies nanocarrier clearance by distinct macrophage subsets
title_sort	surface chemistry-mediated modulation of adsorbed albumin folding state specifies nanocarrier clearance by distinct macrophage subsets
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/15a179777f9c4b2e8d6492098d24f2b1
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Surface chemistry-mediated modulation of adsorbed albumin folding state specifies nanocarrier clearance by distinct macrophage subsets

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