Comprehensive T cell repertoire characterization of non-small cell lung cancer

Relevant features of T cell repertoire in human cancer remain to be delineated. Here the authors show, by TCR sequencing in a large cohort of lung cancer patients, that while a majority of T cell clones are shared between tumor and adjacent lung tissue, less frequent tumor-unique T cell clones corre...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Alexandre Reuben, Jiexin Zhang, Shin-Heng Chiou, Rachel M. Gittelman, Jun Li, Won-Chul Lee, Junya Fujimoto, Carmen Behrens, Xiaoke Liu, Feng Wang, Kelly Quek, Chunlin Wang, Farrah Kheradmand, Runzhe Chen, Chi-Wan Chow, Heather Lin, Chantale Bernatchez, Ali Jalali, Xin Hu, Chang-Jiun Wu, Agda Karina Eterovic, Edwin Roger Parra, Erik Yusko, Ryan Emerson, Sharon Benzeno, Marissa Vignali, Xifeng Wu, Yuanqing Ye, Latasha D. Little, Curtis Gumbs, Xizeng Mao, Xingzhi Song, Samantha Tippen, Rebecca L. Thornton, Tina Cascone, Alexandra Snyder, Jennifer A. Wargo, Roy Herbst, Stephen Swisher, Humam Kadara, Cesar Moran, Neda Kalhor, Jianhua Zhang, Paul Scheet, Ara A. Vaporciyan, Boris Sepesi, Don L. Gibbons, Harlan Robins, Patrick Hwu, John V. Heymach, Padmanee Sharma, James P. Allison, Veera Baladandayuthapani, Jack J. Lee, Mark M. Davis, Ignacio I. Wistuba, P. Andrew Futreal, Jianjun Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/15a3818a702a41f18e727456b0714f76
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:15a3818a702a41f18e727456b0714f76
record_format	dspace
spelling	oai:doaj.org-article:15a3818a702a41f18e727456b0714f762021-12-02T16:56:34ZComprehensive T cell repertoire characterization of non-small cell lung cancer10.1038/s41467-019-14273-02041-1723https://doaj.org/article/15a3818a702a41f18e727456b0714f762020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14273-0https://doaj.org/toc/2041-1723Relevant features of T cell repertoire in human cancer remain to be delineated. Here the authors show, by TCR sequencing in a large cohort of lung cancer patients, that while a majority of T cell clones are shared between tumor and adjacent lung tissue, less frequent tumor-unique T cell clones correlate with worse prognosis.Alexandre ReubenJiexin ZhangShin-Heng ChiouRachel M. GittelmanJun LiWon-Chul LeeJunya FujimotoCarmen BehrensXiaoke LiuFeng WangKelly QuekChunlin WangFarrah KheradmandRunzhe ChenChi-Wan ChowHeather LinChantale BernatchezAli JalaliXin HuChang-Jiun WuAgda Karina EterovicEdwin Roger ParraErik YuskoRyan EmersonSharon BenzenoMarissa VignaliXifeng WuYuanqing YeLatasha D. LittleCurtis GumbsXizeng MaoXingzhi SongSamantha TippenRebecca L. ThorntonTina CasconeAlexandra SnyderJennifer A. WargoRoy HerbstStephen SwisherHumam KadaraCesar MoranNeda KalhorJianhua ZhangPaul ScheetAra A. VaporciyanBoris SepesiDon L. GibbonsHarlan RobinsPatrick HwuJohn V. HeymachPadmanee SharmaJames P. AllisonVeera BaladandayuthapaniJack J. LeeMark M. DavisIgnacio I. WistubaP. Andrew FutrealJianjun ZhangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alexandre Reuben Jiexin Zhang Shin-Heng Chiou Rachel M. Gittelman Jun Li Won-Chul Lee Junya Fujimoto Carmen Behrens Xiaoke Liu Feng Wang Kelly Quek Chunlin Wang Farrah Kheradmand Runzhe Chen Chi-Wan Chow Heather Lin Chantale Bernatchez Ali Jalali Xin Hu Chang-Jiun Wu Agda Karina Eterovic Edwin Roger Parra Erik Yusko Ryan Emerson Sharon Benzeno Marissa Vignali Xifeng Wu Yuanqing Ye Latasha D. Little Curtis Gumbs Xizeng Mao Xingzhi Song Samantha Tippen Rebecca L. Thornton Tina Cascone Alexandra Snyder Jennifer A. Wargo Roy Herbst Stephen Swisher Humam Kadara Cesar Moran Neda Kalhor Jianhua Zhang Paul Scheet Ara A. Vaporciyan Boris Sepesi Don L. Gibbons Harlan Robins Patrick Hwu John V. Heymach Padmanee Sharma James P. Allison Veera Baladandayuthapani Jack J. Lee Mark M. Davis Ignacio I. Wistuba P. Andrew Futreal Jianjun Zhang Comprehensive T cell repertoire characterization of non-small cell lung cancer
description	Relevant features of T cell repertoire in human cancer remain to be delineated. Here the authors show, by TCR sequencing in a large cohort of lung cancer patients, that while a majority of T cell clones are shared between tumor and adjacent lung tissue, less frequent tumor-unique T cell clones correlate with worse prognosis.
format	article
author	Alexandre Reuben Jiexin Zhang Shin-Heng Chiou Rachel M. Gittelman Jun Li Won-Chul Lee Junya Fujimoto Carmen Behrens Xiaoke Liu Feng Wang Kelly Quek Chunlin Wang Farrah Kheradmand Runzhe Chen Chi-Wan Chow Heather Lin Chantale Bernatchez Ali Jalali Xin Hu Chang-Jiun Wu Agda Karina Eterovic Edwin Roger Parra Erik Yusko Ryan Emerson Sharon Benzeno Marissa Vignali Xifeng Wu Yuanqing Ye Latasha D. Little Curtis Gumbs Xizeng Mao Xingzhi Song Samantha Tippen Rebecca L. Thornton Tina Cascone Alexandra Snyder Jennifer A. Wargo Roy Herbst Stephen Swisher Humam Kadara Cesar Moran Neda Kalhor Jianhua Zhang Paul Scheet Ara A. Vaporciyan Boris Sepesi Don L. Gibbons Harlan Robins Patrick Hwu John V. Heymach Padmanee Sharma James P. Allison Veera Baladandayuthapani Jack J. Lee Mark M. Davis Ignacio I. Wistuba P. Andrew Futreal Jianjun Zhang
author_facet	Alexandre Reuben Jiexin Zhang Shin-Heng Chiou Rachel M. Gittelman Jun Li Won-Chul Lee Junya Fujimoto Carmen Behrens Xiaoke Liu Feng Wang Kelly Quek Chunlin Wang Farrah Kheradmand Runzhe Chen Chi-Wan Chow Heather Lin Chantale Bernatchez Ali Jalali Xin Hu Chang-Jiun Wu Agda Karina Eterovic Edwin Roger Parra Erik Yusko Ryan Emerson Sharon Benzeno Marissa Vignali Xifeng Wu Yuanqing Ye Latasha D. Little Curtis Gumbs Xizeng Mao Xingzhi Song Samantha Tippen Rebecca L. Thornton Tina Cascone Alexandra Snyder Jennifer A. Wargo Roy Herbst Stephen Swisher Humam Kadara Cesar Moran Neda Kalhor Jianhua Zhang Paul Scheet Ara A. Vaporciyan Boris Sepesi Don L. Gibbons Harlan Robins Patrick Hwu John V. Heymach Padmanee Sharma James P. Allison Veera Baladandayuthapani Jack J. Lee Mark M. Davis Ignacio I. Wistuba P. Andrew Futreal Jianjun Zhang
author_sort	Alexandre Reuben
title	Comprehensive T cell repertoire characterization of non-small cell lung cancer
title_short	Comprehensive T cell repertoire characterization of non-small cell lung cancer
title_full	Comprehensive T cell repertoire characterization of non-small cell lung cancer
title_fullStr	Comprehensive T cell repertoire characterization of non-small cell lung cancer
title_full_unstemmed	Comprehensive T cell repertoire characterization of non-small cell lung cancer
title_sort	comprehensive t cell repertoire characterization of non-small cell lung cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/15a3818a702a41f18e727456b0714f76
work_keys_str_mv	AT alexandrereuben comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT jiexinzhang comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT shinhengchiou comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT rachelmgittelman comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT junli comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT wonchullee comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT junyafujimoto comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT carmenbehrens comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT xiaokeliu comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT fengwang comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT kellyquek comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT chunlinwang comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT farrahkheradmand comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT runzhechen comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT chiwanchow comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT heatherlin comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT chantalebernatchez comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT alijalali comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT xinhu comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT changjiunwu comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT agdakarinaeterovic comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT edwinrogerparra comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT erikyusko comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT ryanemerson comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT sharonbenzeno comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT marissavignali comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT xifengwu comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT yuanqingye comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT latashadlittle comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT curtisgumbs comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT xizengmao comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT xingzhisong comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT samanthatippen comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT rebeccalthornton comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT tinacascone comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT alexandrasnyder comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT jenniferawargo comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT royherbst comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT stephenswisher comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT humamkadara comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT cesarmoran comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT nedakalhor comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT jianhuazhang comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT paulscheet comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT araavaporciyan comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT borissepesi comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT donlgibbons comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT harlanrobins comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT patrickhwu comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT johnvheymach comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT padmaneesharma comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT jamespallison comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT veerabaladandayuthapani comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT jackjlee comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT markmdavis comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT ignacioiwistuba comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT pandrewfutreal comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer AT jianjunzhang comprehensivetcellrepertoirecharacterizationofnonsmallcelllungcancer
_version_	1718382783294865408

Comprehensive T cell repertoire characterization of non-small cell lung cancer

Ejemplares similares