Factors influencing retention in care after starting antiretroviral therapy in a rural South African programme.

<h4>Introduction</h4>The prognosis of patients with HIV in Africa has improved with the widespread use of antiretroviral therapy (ART) but these successes are threatened by low rates of long-term retention in care. There are limited data on predictors of retention in care, particularly f...

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Autores principales:	Tom H Boyles, Lynne S Wilkinson, Rory Leisegang, Gary Maartens
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/15a8d7d7debf4048b2e08a86c1a49475
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spelling	oai:doaj.org-article:15a8d7d7debf4048b2e08a86c1a494752021-11-18T06:54:33ZFactors influencing retention in care after starting antiretroviral therapy in a rural South African programme.1932-620310.1371/journal.pone.0019201https://doaj.org/article/15a8d7d7debf4048b2e08a86c1a494752011-05-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21559280/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Introduction</h4>The prognosis of patients with HIV in Africa has improved with the widespread use of antiretroviral therapy (ART) but these successes are threatened by low rates of long-term retention in care. There are limited data on predictors of retention in care, particularly from rural sites.<h4>Methods</h4>Prospective cohort analysis of outcome measures in adults from a rural HIV care programme in Madwaleni, Eastern Cape, South Africa. The ART programme operates from Madwaleni hospital and seven primary care feeder clinics with full integration between inpatient and outpatient services. Outreach workers conducted home visits for defaulters.<h4>Results</h4>1803 adults initiated ART from June 2005 to May 2009. At the end of the study period 82.4% were in active care or had transferred elsewhere, 11.1% had died and 6.5% were lost to follow-up (LTFU). Independent predictors associated with an increased risk of LTFU were CD4 nadir >200, initiating ART as an inpatient or while pregnant, and younger age, while being in care for >6 months before initiating ART was associated with a reduced risk. Independent factors associated with an increased risk of mortality were baseline CD4 count <50 and initiating ART as an inpatient, while being in care for >6 months before initiating ART and initiating ART while pregnant were associated with a reduced risk.<h4>Conclusions</h4>Serving a socioeconomically deprived rural population is not a barrier to successful ART delivery. Patients initiating ART while pregnant and inpatients may require additional counselling and support to reduce LTFU. Providing HIV care for patients not yet eligible for ART may be protective against being LTFU and dying after ART initiation.Tom H BoylesLynne S WilkinsonRory LeisegangGary MaartensPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 5, p e19201 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tom H Boyles Lynne S Wilkinson Rory Leisegang Gary Maartens Factors influencing retention in care after starting antiretroviral therapy in a rural South African programme.
description	<h4>Introduction</h4>The prognosis of patients with HIV in Africa has improved with the widespread use of antiretroviral therapy (ART) but these successes are threatened by low rates of long-term retention in care. There are limited data on predictors of retention in care, particularly from rural sites.<h4>Methods</h4>Prospective cohort analysis of outcome measures in adults from a rural HIV care programme in Madwaleni, Eastern Cape, South Africa. The ART programme operates from Madwaleni hospital and seven primary care feeder clinics with full integration between inpatient and outpatient services. Outreach workers conducted home visits for defaulters.<h4>Results</h4>1803 adults initiated ART from June 2005 to May 2009. At the end of the study period 82.4% were in active care or had transferred elsewhere, 11.1% had died and 6.5% were lost to follow-up (LTFU). Independent predictors associated with an increased risk of LTFU were CD4 nadir >200, initiating ART as an inpatient or while pregnant, and younger age, while being in care for >6 months before initiating ART was associated with a reduced risk. Independent factors associated with an increased risk of mortality were baseline CD4 count <50 and initiating ART as an inpatient, while being in care for >6 months before initiating ART and initiating ART while pregnant were associated with a reduced risk.<h4>Conclusions</h4>Serving a socioeconomically deprived rural population is not a barrier to successful ART delivery. Patients initiating ART while pregnant and inpatients may require additional counselling and support to reduce LTFU. Providing HIV care for patients not yet eligible for ART may be protective against being LTFU and dying after ART initiation.
format	article
author	Tom H Boyles Lynne S Wilkinson Rory Leisegang Gary Maartens
author_facet	Tom H Boyles Lynne S Wilkinson Rory Leisegang Gary Maartens
author_sort	Tom H Boyles
title	Factors influencing retention in care after starting antiretroviral therapy in a rural South African programme.
title_short	Factors influencing retention in care after starting antiretroviral therapy in a rural South African programme.
title_full	Factors influencing retention in care after starting antiretroviral therapy in a rural South African programme.
title_fullStr	Factors influencing retention in care after starting antiretroviral therapy in a rural South African programme.
title_full_unstemmed	Factors influencing retention in care after starting antiretroviral therapy in a rural South African programme.
title_sort	factors influencing retention in care after starting antiretroviral therapy in a rural south african programme.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/15a8d7d7debf4048b2e08a86c1a49475
work_keys_str_mv	AT tomhboyles factorsinfluencingretentionincareafterstartingantiretroviraltherapyinaruralsouthafricanprogramme AT lynneswilkinson factorsinfluencingretentionincareafterstartingantiretroviraltherapyinaruralsouthafricanprogramme AT roryleisegang factorsinfluencingretentionincareafterstartingantiretroviraltherapyinaruralsouthafricanprogramme AT garymaartens factorsinfluencingretentionincareafterstartingantiretroviraltherapyinaruralsouthafricanprogramme
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Factors influencing retention in care after starting antiretroviral therapy in a rural South African programme.

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