Androgen receptor-binding sites are highly mutated in prostate cancer

Androgen receptor (AR) mediated transcription is critical to prostate tumorigenesis and development. Here, utilising clinical whole genome sequencing data, the authors show that the non-coding AR binding sites on DNA are frequently mutated in prostate cancer potentially due to faulty base excision r...

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Autores principales:	Tunç Morova, Daniel R. McNeill, Nada Lallous, Mehmet Gönen, Kush Dalal, David M. Wilson, Attila Gürsoy, Özlem Keskin, Nathan A. Lack
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/15a98cfbbcff421a8c1487325afd7722
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spelling	oai:doaj.org-article:15a98cfbbcff421a8c1487325afd77222021-12-02T17:32:59ZAndrogen receptor-binding sites are highly mutated in prostate cancer10.1038/s41467-020-14644-y2041-1723https://doaj.org/article/15a98cfbbcff421a8c1487325afd77222020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14644-yhttps://doaj.org/toc/2041-1723Androgen receptor (AR) mediated transcription is critical to prostate tumorigenesis and development. Here, utilising clinical whole genome sequencing data, the authors show that the non-coding AR binding sites on DNA are frequently mutated in prostate cancer potentially due to faulty base excision repair mechanismsTunç MorovaDaniel R. McNeillNada LallousMehmet GönenKush DalalDavid M. WilsonAttila GürsoyÖzlem KeskinNathan A. LackNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tunç Morova Daniel R. McNeill Nada Lallous Mehmet Gönen Kush Dalal David M. Wilson Attila Gürsoy Özlem Keskin Nathan A. Lack Androgen receptor-binding sites are highly mutated in prostate cancer
description	Androgen receptor (AR) mediated transcription is critical to prostate tumorigenesis and development. Here, utilising clinical whole genome sequencing data, the authors show that the non-coding AR binding sites on DNA are frequently mutated in prostate cancer potentially due to faulty base excision repair mechanisms
format	article
author	Tunç Morova Daniel R. McNeill Nada Lallous Mehmet Gönen Kush Dalal David M. Wilson Attila Gürsoy Özlem Keskin Nathan A. Lack
author_facet	Tunç Morova Daniel R. McNeill Nada Lallous Mehmet Gönen Kush Dalal David M. Wilson Attila Gürsoy Özlem Keskin Nathan A. Lack
author_sort	Tunç Morova
title	Androgen receptor-binding sites are highly mutated in prostate cancer
title_short	Androgen receptor-binding sites are highly mutated in prostate cancer
title_full	Androgen receptor-binding sites are highly mutated in prostate cancer
title_fullStr	Androgen receptor-binding sites are highly mutated in prostate cancer
title_full_unstemmed	Androgen receptor-binding sites are highly mutated in prostate cancer
title_sort	androgen receptor-binding sites are highly mutated in prostate cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/15a98cfbbcff421a8c1487325afd7722
work_keys_str_mv	AT tuncmorova androgenreceptorbindingsitesarehighlymutatedinprostatecancer AT danielrmcneill androgenreceptorbindingsitesarehighlymutatedinprostatecancer AT nadalallous androgenreceptorbindingsitesarehighlymutatedinprostatecancer AT mehmetgonen androgenreceptorbindingsitesarehighlymutatedinprostatecancer AT kushdalal androgenreceptorbindingsitesarehighlymutatedinprostatecancer AT davidmwilson androgenreceptorbindingsitesarehighlymutatedinprostatecancer AT attilagursoy androgenreceptorbindingsitesarehighlymutatedinprostatecancer AT ozlemkeskin androgenreceptorbindingsitesarehighlymutatedinprostatecancer AT nathanalack androgenreceptorbindingsitesarehighlymutatedinprostatecancer
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Androgen receptor-binding sites are highly mutated in prostate cancer

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