Aneurysm risk metrics and hemodynamics are associated with greater vessel wall enhancement in intracranial aneurysms

Vessel wall enhancement (VWE) in contrast-enhanced magnetic resonance imaging (MRI) is a potential biomarker for intracranial aneurysm (IA) risk stratification. In this study, we investigated the relationship between VWE features, risk metrics, morphology and hemodynamics in 41 unruptured aneurysms....

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Autores principales:	Sricharan S. Veeturi, Hamidreza Rajabzadeh-Oghaz, Nándor K. Pintér, Muhammad Waqas, David M. Hasan, Kenneth V. Snyder, Adnan H. Siddiqui, Vincent M. Tutino
Formato:	article
Lenguaje:	EN
Publicado:	The Royal Society 2021
Materias:	cerebral aneurysm computational fluid dynamics hemodynamics vessel wall enhancement magnetic resonance imaging Science Q
Acceso en línea:	https://doaj.org/article/15aa92b2c96f4cb398032e5c19decf2e
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spelling	oai:doaj.org-article:15aa92b2c96f4cb398032e5c19decf2e2021-11-10T08:06:33ZAneurysm risk metrics and hemodynamics are associated with greater vessel wall enhancement in intracranial aneurysms10.1098/rsos.2111192054-5703https://doaj.org/article/15aa92b2c96f4cb398032e5c19decf2e2021-11-01T00:00:00Zhttps://royalsocietypublishing.org/doi/10.1098/rsos.211119https://doaj.org/toc/2054-5703Vessel wall enhancement (VWE) in contrast-enhanced magnetic resonance imaging (MRI) is a potential biomarker for intracranial aneurysm (IA) risk stratification. In this study, we investigated the relationship between VWE features, risk metrics, morphology and hemodynamics in 41 unruptured aneurysms. We reconstructed the IA geometries from MR angiography and mapped pituitary stalk-normalized MRI intensity on the aneurysm surface using an in-house tool. For each case, we calculated the maximum intensity (CRstalk) and IA risk (via size and the rupture resemblance score (RRS)). We performed correlation analysis to assess relationships between CRstalk and IA risk metrics (size and RRS), as well as each parameter encompassed in RRS, i.e. aneurysmal size ratio (SR), normalized wall shear stress (WSS) and oscillatory shear index. We found that CRstalk had a strong correlation (Pearson correlation coefficient, PCC = 0.630) with size and a moderate correlation (PCC = 0.472) with RRS, indicating an association between VWE and IA risk. Furthermore, CRstalk had a weak negative correlation with normalized WSS (PCC = −0.320) and a weak positive correlation with SR (PCC = 0.390). Local voxel-based analysis showed only a weak negative correlation between normalized WSS and contrast-enhanced MRI signal intensity (PCC = −0.240), suggesting that if low-normalized WSS induces enhancement-associated pathobiology, the effect is not localized.Sricharan S. VeeturiHamidreza Rajabzadeh-OghazNándor K. PintérMuhammad WaqasDavid M. HasanKenneth V. SnyderAdnan H. SiddiquiVincent M. TutinoThe Royal Societyarticlecerebral aneurysmcomputational fluid dynamicshemodynamicsvessel wall enhancementmagnetic resonance imagingScienceQENRoyal Society Open Science, Vol 8, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cerebral aneurysm computational fluid dynamics hemodynamics vessel wall enhancement magnetic resonance imaging Science Q
spellingShingle	cerebral aneurysm computational fluid dynamics hemodynamics vessel wall enhancement magnetic resonance imaging Science Q Sricharan S. Veeturi Hamidreza Rajabzadeh-Oghaz Nándor K. Pintér Muhammad Waqas David M. Hasan Kenneth V. Snyder Adnan H. Siddiqui Vincent M. Tutino Aneurysm risk metrics and hemodynamics are associated with greater vessel wall enhancement in intracranial aneurysms
description	Vessel wall enhancement (VWE) in contrast-enhanced magnetic resonance imaging (MRI) is a potential biomarker for intracranial aneurysm (IA) risk stratification. In this study, we investigated the relationship between VWE features, risk metrics, morphology and hemodynamics in 41 unruptured aneurysms. We reconstructed the IA geometries from MR angiography and mapped pituitary stalk-normalized MRI intensity on the aneurysm surface using an in-house tool. For each case, we calculated the maximum intensity (CRstalk) and IA risk (via size and the rupture resemblance score (RRS)). We performed correlation analysis to assess relationships between CRstalk and IA risk metrics (size and RRS), as well as each parameter encompassed in RRS, i.e. aneurysmal size ratio (SR), normalized wall shear stress (WSS) and oscillatory shear index. We found that CRstalk had a strong correlation (Pearson correlation coefficient, PCC = 0.630) with size and a moderate correlation (PCC = 0.472) with RRS, indicating an association between VWE and IA risk. Furthermore, CRstalk had a weak negative correlation with normalized WSS (PCC = −0.320) and a weak positive correlation with SR (PCC = 0.390). Local voxel-based analysis showed only a weak negative correlation between normalized WSS and contrast-enhanced MRI signal intensity (PCC = −0.240), suggesting that if low-normalized WSS induces enhancement-associated pathobiology, the effect is not localized.
format	article
author	Sricharan S. Veeturi Hamidreza Rajabzadeh-Oghaz Nándor K. Pintér Muhammad Waqas David M. Hasan Kenneth V. Snyder Adnan H. Siddiqui Vincent M. Tutino
author_facet	Sricharan S. Veeturi Hamidreza Rajabzadeh-Oghaz Nándor K. Pintér Muhammad Waqas David M. Hasan Kenneth V. Snyder Adnan H. Siddiqui Vincent M. Tutino
author_sort	Sricharan S. Veeturi
title	Aneurysm risk metrics and hemodynamics are associated with greater vessel wall enhancement in intracranial aneurysms
title_short	Aneurysm risk metrics and hemodynamics are associated with greater vessel wall enhancement in intracranial aneurysms
title_full	Aneurysm risk metrics and hemodynamics are associated with greater vessel wall enhancement in intracranial aneurysms
title_fullStr	Aneurysm risk metrics and hemodynamics are associated with greater vessel wall enhancement in intracranial aneurysms
title_full_unstemmed	Aneurysm risk metrics and hemodynamics are associated with greater vessel wall enhancement in intracranial aneurysms
title_sort	aneurysm risk metrics and hemodynamics are associated with greater vessel wall enhancement in intracranial aneurysms
publisher	The Royal Society
publishDate	2021
url	https://doaj.org/article/15aa92b2c96f4cb398032e5c19decf2e
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_version_	1718440350518870016

Aneurysm risk metrics and hemodynamics are associated with greater vessel wall enhancement in intracranial aneurysms

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