Impact of anemia on in-stent restenosis after percutaneous coronary intervention

Abstract Background Anemia is a common risk factor for post-percutaneous coronary intervention (PCI) adverse events; however, data on its association with in-stent restenosis (ISR) is limited. Methods 538 patients who underwent PCI between January 2017 and September 2019 and follow-up angiography 9–...

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Autores principales:	Huilin Hu, Shijun Wang, Guanmin Tang, Changlin Zhai, Liang Shen
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Anemia In-stent restenosis Percutaneous coronary intervention Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/15acce96d22848db8bb7bf197bce204a
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spelling	oai:doaj.org-article:15acce96d22848db8bb7bf197bce204a2021-11-21T12:04:15ZImpact of anemia on in-stent restenosis after percutaneous coronary intervention10.1186/s12872-021-02355-11471-2261https://doaj.org/article/15acce96d22848db8bb7bf197bce204a2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12872-021-02355-1https://doaj.org/toc/1471-2261Abstract Background Anemia is a common risk factor for post-percutaneous coronary intervention (PCI) adverse events; however, data on its association with in-stent restenosis (ISR) is limited. Methods 538 patients who underwent PCI between January 2017 and September 2019 and follow-up angiography 9–12 months after the initial PCI were enrolled in this study. Baseline clinical and procedural characteristics were compared between the ISR and non-ISR groups, and independent predictors of ISR were determined using propensity score matching. Results The incidence of anemia was 53.5% in patients with ISR and 19.0% in those without ISR. Univariable logistic regression analyses showed that anemia (OR, 4.283; 95% CI, 1.949–9.410; P < 0.001), diabetes mellitus (OR, 2.588; 95% CI, 1.176–5.696; P = 0.018), chronic kidney disease (OR, 3.058; 95% CI, 1.289–7.252; P = 0.011), multiple stenting (OR, 2.592; 95% CI, 1.205–5.573; P = 0.015), bifurcation lesion (OR, 2.669; 95% CI, 1.236–5.763; P = 0.012), and calcification (OR, 3.529; 95% CI, 1.131–11.014; P = 0.030) were closely associated with ISR. Low-density lipoprotein cholesterol (LDL-c) levels and stent diameter were also significantly linked to ISR, as was anemia (P = 0.009) after propensity score matching. Conclusion Anemia is closely associated with post-PCI ISR, and patients with lower hemoglobin levels are at a higher risk of ISR.Huilin HuShijun WangGuanmin TangChanglin ZhaiLiang ShenBMCarticleAnemiaIn-stent restenosisPercutaneous coronary interventionDiseases of the circulatory (Cardiovascular) systemRC666-701ENBMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Anemia In-stent restenosis Percutaneous coronary intervention Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Anemia In-stent restenosis Percutaneous coronary intervention Diseases of the circulatory (Cardiovascular) system RC666-701 Huilin Hu Shijun Wang Guanmin Tang Changlin Zhai Liang Shen Impact of anemia on in-stent restenosis after percutaneous coronary intervention
description	Abstract Background Anemia is a common risk factor for post-percutaneous coronary intervention (PCI) adverse events; however, data on its association with in-stent restenosis (ISR) is limited. Methods 538 patients who underwent PCI between January 2017 and September 2019 and follow-up angiography 9–12 months after the initial PCI were enrolled in this study. Baseline clinical and procedural characteristics were compared between the ISR and non-ISR groups, and independent predictors of ISR were determined using propensity score matching. Results The incidence of anemia was 53.5% in patients with ISR and 19.0% in those without ISR. Univariable logistic regression analyses showed that anemia (OR, 4.283; 95% CI, 1.949–9.410; P < 0.001), diabetes mellitus (OR, 2.588; 95% CI, 1.176–5.696; P = 0.018), chronic kidney disease (OR, 3.058; 95% CI, 1.289–7.252; P = 0.011), multiple stenting (OR, 2.592; 95% CI, 1.205–5.573; P = 0.015), bifurcation lesion (OR, 2.669; 95% CI, 1.236–5.763; P = 0.012), and calcification (OR, 3.529; 95% CI, 1.131–11.014; P = 0.030) were closely associated with ISR. Low-density lipoprotein cholesterol (LDL-c) levels and stent diameter were also significantly linked to ISR, as was anemia (P = 0.009) after propensity score matching. Conclusion Anemia is closely associated with post-PCI ISR, and patients with lower hemoglobin levels are at a higher risk of ISR.
format	article
author	Huilin Hu Shijun Wang Guanmin Tang Changlin Zhai Liang Shen
author_facet	Huilin Hu Shijun Wang Guanmin Tang Changlin Zhai Liang Shen
author_sort	Huilin Hu
title	Impact of anemia on in-stent restenosis after percutaneous coronary intervention
title_short	Impact of anemia on in-stent restenosis after percutaneous coronary intervention
title_full	Impact of anemia on in-stent restenosis after percutaneous coronary intervention
title_fullStr	Impact of anemia on in-stent restenosis after percutaneous coronary intervention
title_full_unstemmed	Impact of anemia on in-stent restenosis after percutaneous coronary intervention
title_sort	impact of anemia on in-stent restenosis after percutaneous coronary intervention
publisher	BMC
publishDate	2021
url	https://doaj.org/article/15acce96d22848db8bb7bf197bce204a
work_keys_str_mv	AT huilinhu impactofanemiaoninstentrestenosisafterpercutaneouscoronaryintervention AT shijunwang impactofanemiaoninstentrestenosisafterpercutaneouscoronaryintervention AT guanmintang impactofanemiaoninstentrestenosisafterpercutaneouscoronaryintervention AT changlinzhai impactofanemiaoninstentrestenosisafterpercutaneouscoronaryintervention AT liangshen impactofanemiaoninstentrestenosisafterpercutaneouscoronaryintervention
_version_	1718419228831252480

Impact of anemia on in-stent restenosis after percutaneous coronary intervention

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