Using auditory steady state responses to outline the functional connectivity in the tinnitus brain.

<h4>Background</h4>Tinnitus is an auditory phantom perception that is most likely generated in the central nervous system. Most of the tinnitus research has concentrated on the auditory system. However, it was suggested recently that also non-auditory structures are involved in a global...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Winfried Schlee, Nathan Weisz, Olivier Bertrand, Thomas Hartmann, Thomas Elbert
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/15aea967e8c34f4c8b849ec9a01187bf
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:15aea967e8c34f4c8b849ec9a01187bf
record_format	dspace
spelling	oai:doaj.org-article:15aea967e8c34f4c8b849ec9a01187bf2021-11-25T06:18:32ZUsing auditory steady state responses to outline the functional connectivity in the tinnitus brain.1932-620310.1371/journal.pone.0003720https://doaj.org/article/15aea967e8c34f4c8b849ec9a01187bf2008-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19005566/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Tinnitus is an auditory phantom perception that is most likely generated in the central nervous system. Most of the tinnitus research has concentrated on the auditory system. However, it was suggested recently that also non-auditory structures are involved in a global network that encodes subjective tinnitus. We tested this assumption using auditory steady state responses to entrain the tinnitus network and investigated long-range functional connectivity across various non-auditory brain regions.<h4>Methods and findings</h4>Using whole-head magnetoencephalography we investigated cortical connectivity by means of phase synchronization in tinnitus subjects and healthy controls. We found evidence for a deviating pattern of long-range functional connectivity in tinnitus that was strongly correlated with individual ratings of the tinnitus percept. Phase couplings between the anterior cingulum and the right frontal lobe and phase couplings between the anterior cingulum and the right parietal lobe showed significant condition x group interactions and were correlated with the individual tinnitus distress ratings only in the tinnitus condition and not in the control conditions.<h4>Conclusions</h4>To the best of our knowledge this is the first study that demonstrates existence of a global tinnitus network of long-range cortical connections outside the central auditory system. This result extends the current knowledge of how tinnitus is generated in the brain. We propose that this global extend of the tinnitus network is crucial for the continuos perception of the tinnitus tone and a therapeutical intervention that is able to change this network should result in relief of tinnitus.Winfried SchleeNathan WeiszOlivier BertrandThomas HartmannThomas ElbertPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 3, Iss 11, p e3720 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Winfried Schlee Nathan Weisz Olivier Bertrand Thomas Hartmann Thomas Elbert Using auditory steady state responses to outline the functional connectivity in the tinnitus brain.
description	<h4>Background</h4>Tinnitus is an auditory phantom perception that is most likely generated in the central nervous system. Most of the tinnitus research has concentrated on the auditory system. However, it was suggested recently that also non-auditory structures are involved in a global network that encodes subjective tinnitus. We tested this assumption using auditory steady state responses to entrain the tinnitus network and investigated long-range functional connectivity across various non-auditory brain regions.<h4>Methods and findings</h4>Using whole-head magnetoencephalography we investigated cortical connectivity by means of phase synchronization in tinnitus subjects and healthy controls. We found evidence for a deviating pattern of long-range functional connectivity in tinnitus that was strongly correlated with individual ratings of the tinnitus percept. Phase couplings between the anterior cingulum and the right frontal lobe and phase couplings between the anterior cingulum and the right parietal lobe showed significant condition x group interactions and were correlated with the individual tinnitus distress ratings only in the tinnitus condition and not in the control conditions.<h4>Conclusions</h4>To the best of our knowledge this is the first study that demonstrates existence of a global tinnitus network of long-range cortical connections outside the central auditory system. This result extends the current knowledge of how tinnitus is generated in the brain. We propose that this global extend of the tinnitus network is crucial for the continuos perception of the tinnitus tone and a therapeutical intervention that is able to change this network should result in relief of tinnitus.
format	article
author	Winfried Schlee Nathan Weisz Olivier Bertrand Thomas Hartmann Thomas Elbert
author_facet	Winfried Schlee Nathan Weisz Olivier Bertrand Thomas Hartmann Thomas Elbert
author_sort	Winfried Schlee
title	Using auditory steady state responses to outline the functional connectivity in the tinnitus brain.
title_short	Using auditory steady state responses to outline the functional connectivity in the tinnitus brain.
title_full	Using auditory steady state responses to outline the functional connectivity in the tinnitus brain.
title_fullStr	Using auditory steady state responses to outline the functional connectivity in the tinnitus brain.
title_full_unstemmed	Using auditory steady state responses to outline the functional connectivity in the tinnitus brain.
title_sort	using auditory steady state responses to outline the functional connectivity in the tinnitus brain.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/15aea967e8c34f4c8b849ec9a01187bf
work_keys_str_mv	AT winfriedschlee usingauditorysteadystateresponsestooutlinethefunctionalconnectivityinthetinnitusbrain AT nathanweisz usingauditorysteadystateresponsestooutlinethefunctionalconnectivityinthetinnitusbrain AT olivierbertrand usingauditorysteadystateresponsestooutlinethefunctionalconnectivityinthetinnitusbrain AT thomashartmann usingauditorysteadystateresponsestooutlinethefunctionalconnectivityinthetinnitusbrain AT thomaselbert usingauditorysteadystateresponsestooutlinethefunctionalconnectivityinthetinnitusbrain
_version_	1718413907166494720

Using auditory steady state responses to outline the functional connectivity in the tinnitus brain.

Ejemplares similares