PKC-phosphorylation of Liprin-α3 triggers phase separation and controls presynaptic active zone structure

Liquid–liquid phase separation may be a mechanism for organizing the presynaptic nerve terminal. Here, the authors show that PKC-mediated phosphorylation of Liprin-α3 triggers phase separation in cell lines and modulates active zone structure and function in primary hippocampal neurons.

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Autores principales:	Javier Emperador-Melero, Man Yan Wong, Shan Shan H. Wang, Giovanni de Nola, Hajnalka Nyitrai, Tom Kirchhausen, Pascal S. Kaeser
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/15b0f79f4c614f568a9dd724cdd9d663
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spelling	oai:doaj.org-article:15b0f79f4c614f568a9dd724cdd9d6632021-12-02T15:49:30ZPKC-phosphorylation of Liprin-α3 triggers phase separation and controls presynaptic active zone structure10.1038/s41467-021-23116-w2041-1723https://doaj.org/article/15b0f79f4c614f568a9dd724cdd9d6632021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23116-whttps://doaj.org/toc/2041-1723Liquid–liquid phase separation may be a mechanism for organizing the presynaptic nerve terminal. Here, the authors show that PKC-mediated phosphorylation of Liprin-α3 triggers phase separation in cell lines and modulates active zone structure and function in primary hippocampal neurons.Javier Emperador-MeleroMan Yan WongShan Shan H. WangGiovanni de NolaHajnalka NyitraiTom KirchhausenPascal S. KaeserNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Javier Emperador-Melero Man Yan Wong Shan Shan H. Wang Giovanni de Nola Hajnalka Nyitrai Tom Kirchhausen Pascal S. Kaeser PKC-phosphorylation of Liprin-α3 triggers phase separation and controls presynaptic active zone structure
description	Liquid–liquid phase separation may be a mechanism for organizing the presynaptic nerve terminal. Here, the authors show that PKC-mediated phosphorylation of Liprin-α3 triggers phase separation in cell lines and modulates active zone structure and function in primary hippocampal neurons.
format	article
author	Javier Emperador-Melero Man Yan Wong Shan Shan H. Wang Giovanni de Nola Hajnalka Nyitrai Tom Kirchhausen Pascal S. Kaeser
author_facet	Javier Emperador-Melero Man Yan Wong Shan Shan H. Wang Giovanni de Nola Hajnalka Nyitrai Tom Kirchhausen Pascal S. Kaeser
author_sort	Javier Emperador-Melero
title	PKC-phosphorylation of Liprin-α3 triggers phase separation and controls presynaptic active zone structure
title_short	PKC-phosphorylation of Liprin-α3 triggers phase separation and controls presynaptic active zone structure
title_full	PKC-phosphorylation of Liprin-α3 triggers phase separation and controls presynaptic active zone structure
title_fullStr	PKC-phosphorylation of Liprin-α3 triggers phase separation and controls presynaptic active zone structure
title_full_unstemmed	PKC-phosphorylation of Liprin-α3 triggers phase separation and controls presynaptic active zone structure
title_sort	pkc-phosphorylation of liprin-α3 triggers phase separation and controls presynaptic active zone structure
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/15b0f79f4c614f568a9dd724cdd9d663
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PKC-phosphorylation of Liprin-α3 triggers phase separation and controls presynaptic active zone structure

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