Overview of the main methods used to combine proteins with nanosystems: absorption, bioconjugation, and encapsulation

Mariagrazia Di Marco1, Shaharum Shamsuddin2, Khairunisak Abdul Razak3, Azlan Abdul Aziz4, Corinne Devaux1, Elsa Borghi1, Laurent Levy1, Claudia Sadun51Nanobiotix, Paris, France; 2School of Health Sciences, Health Campus Universiti Sains Malaysia, Kelantan, Malaysia; 3School of Materials and Mineral...

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Autores principales:	Mariagrazia Di Marco, Shaharum Shamsuddin, Khairunisak Abdul Razak, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2009
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/15b2d1ffa74942c68b5fe2aa86b7b661
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spelling	oai:doaj.org-article:15b2d1ffa74942c68b5fe2aa86b7b6612021-12-02T06:34:20ZOverview of the main methods used to combine proteins with nanosystems: absorption, bioconjugation, and encapsulation1176-91141178-2013https://doaj.org/article/15b2d1ffa74942c68b5fe2aa86b7b6612009-12-01T00:00:00Zhttp://www.dovepress.com/overview-of-the-main-methods-used-to-combine-proteins-with-nanosystems-a3865https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Mariagrazia Di Marco1, Shaharum Shamsuddin2, Khairunisak Abdul Razak3, Azlan Abdul Aziz4, Corinne Devaux1, Elsa Borghi1, Laurent Levy1, Claudia Sadun51Nanobiotix, Paris, France; 2School of Health Sciences, Health Campus Universiti Sains Malaysia, Kelantan, Malaysia; 3School of Materials and Mineral Resources Engineering, Engineering Campus, 4School of Physics, Universiti Sains Malaysia, Penang, Malaysia; 5Department of Chemistry, Sapienza, University of Rome, Rome, ItalyAbstract: The latest development of protein engineering allows the production of proteins having desired properties and large potential markets, but the clinical advances of therapeutical proteins are still limited by their fragility. Nanotechnology could provide optimal vectors able to protect from degradation therapeutical biomolecules such as proteins, enzymes or specific polypeptides. On the other hand, some proteins can be also used as active ligands to help nanoparticles loaded with chemotherapeutic or other drugs to reach particular sites in the body. The aim of this review is to provide an overall picture of the general aspects of the most successful approaches used to combine proteins with nanosystems. This combination is mainly achieved by absorption, bioconjugation and encapsulation. Interactions of nanoparticles with biomolecules and caveats related to protein denaturation are also pointed out. A clear understanding of nanoparticle-protein interactions could make possible the design of precise and versatile hybrid nanosystems. This could further allow control of their pharmacokinetics as well as activity, and safety.Keywords: nanoparticles, drug delivery, proteins, polypeptides, absorption, bioconjugation, encapsulation Mariagrazia Di MarcoShaharum ShamsuddinKhairunisak Abdul Razaket alDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2010, Iss default, Pp 37-49 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Mariagrazia Di Marco Shaharum Shamsuddin Khairunisak Abdul Razak et al Overview of the main methods used to combine proteins with nanosystems: absorption, bioconjugation, and encapsulation
description	Mariagrazia Di Marco1, Shaharum Shamsuddin2, Khairunisak Abdul Razak3, Azlan Abdul Aziz4, Corinne Devaux1, Elsa Borghi1, Laurent Levy1, Claudia Sadun51Nanobiotix, Paris, France; 2School of Health Sciences, Health Campus Universiti Sains Malaysia, Kelantan, Malaysia; 3School of Materials and Mineral Resources Engineering, Engineering Campus, 4School of Physics, Universiti Sains Malaysia, Penang, Malaysia; 5Department of Chemistry, Sapienza, University of Rome, Rome, ItalyAbstract: The latest development of protein engineering allows the production of proteins having desired properties and large potential markets, but the clinical advances of therapeutical proteins are still limited by their fragility. Nanotechnology could provide optimal vectors able to protect from degradation therapeutical biomolecules such as proteins, enzymes or specific polypeptides. On the other hand, some proteins can be also used as active ligands to help nanoparticles loaded with chemotherapeutic or other drugs to reach particular sites in the body. The aim of this review is to provide an overall picture of the general aspects of the most successful approaches used to combine proteins with nanosystems. This combination is mainly achieved by absorption, bioconjugation and encapsulation. Interactions of nanoparticles with biomolecules and caveats related to protein denaturation are also pointed out. A clear understanding of nanoparticle-protein interactions could make possible the design of precise and versatile hybrid nanosystems. This could further allow control of their pharmacokinetics as well as activity, and safety.Keywords: nanoparticles, drug delivery, proteins, polypeptides, absorption, bioconjugation, encapsulation
format	article
author	Mariagrazia Di Marco Shaharum Shamsuddin Khairunisak Abdul Razak et al
author_facet	Mariagrazia Di Marco Shaharum Shamsuddin Khairunisak Abdul Razak et al
author_sort	Mariagrazia Di Marco
title	Overview of the main methods used to combine proteins with nanosystems: absorption, bioconjugation, and encapsulation
title_short	Overview of the main methods used to combine proteins with nanosystems: absorption, bioconjugation, and encapsulation
title_full	Overview of the main methods used to combine proteins with nanosystems: absorption, bioconjugation, and encapsulation
title_fullStr	Overview of the main methods used to combine proteins with nanosystems: absorption, bioconjugation, and encapsulation
title_full_unstemmed	Overview of the main methods used to combine proteins with nanosystems: absorption, bioconjugation, and encapsulation
title_sort	overview of the main methods used to combine proteins with nanosystems: absorption, bioconjugation, and encapsulation
publisher	Dove Medical Press
publishDate	2009
url	https://doaj.org/article/15b2d1ffa74942c68b5fe2aa86b7b661
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Overview of the main methods used to combine proteins with nanosystems: absorption, bioconjugation, and encapsulation

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