Moderate Intensity Aerobic Exercise Potential Favorable Effect Against COVID-19: The Role of Renin-Angiotensin System and Immunomodulatory Effects
The coronavirus disease (COVID-19) pandemic is caused by a novel coronavirus (CoV) named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). As the angiotensin converting enzyme 2 (ACE2) is the cellular receptor of SARS-CoV-2, it has a strong interaction with the renin angiotensin system (...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:15b3acbbe7494cf78533d18ebab7b52d2021-11-15T05:18:03ZModerate Intensity Aerobic Exercise Potential Favorable Effect Against COVID-19: The Role of Renin-Angiotensin System and Immunomodulatory Effects1664-042X10.3389/fphys.2021.747200https://doaj.org/article/15b3acbbe7494cf78533d18ebab7b52d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphys.2021.747200/fullhttps://doaj.org/toc/1664-042XThe coronavirus disease (COVID-19) pandemic is caused by a novel coronavirus (CoV) named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). As the angiotensin converting enzyme 2 (ACE2) is the cellular receptor of SARS-CoV-2, it has a strong interaction with the renin angiotensin system (RAS). Experimental studies have shown that the higher levels of ACE2 or increasing ACE2/ACE1 ratio improve COVID-19 outcomes through lowering inflammation and death. Aerobic moderate intensity physical exercise fights off infections by two mechanisms, the inhibition of ACE/Ang II/AT1-R pathway and the stimulation of ACE2/Ang-(1–7)/MasR axis. Exercise can also activate the anti-inflammatory response so that it can be a potential therapeutic strategy against COVID-19. Here, we summarize and focus the relation among COVID-19, RAS, and immune system and describe the potential effect of aerobic moderate intensity physical exercise against CoV as a useful complementary tool for providing immune protection against SARS-CoV-2 virus infection, which is a novel intervention that requires further investigation.Hamid AraziAkram FalahatiKatsuhiko SuzukiFrontiers Media S.A.articlerenin angiotensin systemSARS-CoV-2coronavirusinflammationimmune protectionPhysiologyQP1-981ENFrontiers in Physiology, Vol 12 (2021) |
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EN |
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renin angiotensin system SARS-CoV-2 coronavirus inflammation immune protection Physiology QP1-981 |
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renin angiotensin system SARS-CoV-2 coronavirus inflammation immune protection Physiology QP1-981 Hamid Arazi Akram Falahati Katsuhiko Suzuki Moderate Intensity Aerobic Exercise Potential Favorable Effect Against COVID-19: The Role of Renin-Angiotensin System and Immunomodulatory Effects |
| description |
The coronavirus disease (COVID-19) pandemic is caused by a novel coronavirus (CoV) named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). As the angiotensin converting enzyme 2 (ACE2) is the cellular receptor of SARS-CoV-2, it has a strong interaction with the renin angiotensin system (RAS). Experimental studies have shown that the higher levels of ACE2 or increasing ACE2/ACE1 ratio improve COVID-19 outcomes through lowering inflammation and death. Aerobic moderate intensity physical exercise fights off infections by two mechanisms, the inhibition of ACE/Ang II/AT1-R pathway and the stimulation of ACE2/Ang-(1–7)/MasR axis. Exercise can also activate the anti-inflammatory response so that it can be a potential therapeutic strategy against COVID-19. Here, we summarize and focus the relation among COVID-19, RAS, and immune system and describe the potential effect of aerobic moderate intensity physical exercise against CoV as a useful complementary tool for providing immune protection against SARS-CoV-2 virus infection, which is a novel intervention that requires further investigation. |
| format |
article |
| author |
Hamid Arazi Akram Falahati Katsuhiko Suzuki |
| author_facet |
Hamid Arazi Akram Falahati Katsuhiko Suzuki |
| author_sort |
Hamid Arazi |
| title |
Moderate Intensity Aerobic Exercise Potential Favorable Effect Against COVID-19: The Role of Renin-Angiotensin System and Immunomodulatory Effects |
| title_short |
Moderate Intensity Aerobic Exercise Potential Favorable Effect Against COVID-19: The Role of Renin-Angiotensin System and Immunomodulatory Effects |
| title_full |
Moderate Intensity Aerobic Exercise Potential Favorable Effect Against COVID-19: The Role of Renin-Angiotensin System and Immunomodulatory Effects |
| title_fullStr |
Moderate Intensity Aerobic Exercise Potential Favorable Effect Against COVID-19: The Role of Renin-Angiotensin System and Immunomodulatory Effects |
| title_full_unstemmed |
Moderate Intensity Aerobic Exercise Potential Favorable Effect Against COVID-19: The Role of Renin-Angiotensin System and Immunomodulatory Effects |
| title_sort |
moderate intensity aerobic exercise potential favorable effect against covid-19: the role of renin-angiotensin system and immunomodulatory effects |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/15b3acbbe7494cf78533d18ebab7b52d |
| work_keys_str_mv |
AT hamidarazi moderateintensityaerobicexercisepotentialfavorableeffectagainstcovid19theroleofreninangiotensinsystemandimmunomodulatoryeffects AT akramfalahati moderateintensityaerobicexercisepotentialfavorableeffectagainstcovid19theroleofreninangiotensinsystemandimmunomodulatoryeffects AT katsuhikosuzuki moderateintensityaerobicexercisepotentialfavorableeffectagainstcovid19theroleofreninangiotensinsystemandimmunomodulatoryeffects |
| _version_ |
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