Impact of outdoor nature-related activities on gut microbiota, fecal serotonin, and perceived stress in preschool children: the Play&Grow randomized controlled trial

Abstract Due to rapid urbanization, children today have fewer opportunities to interact with nature and this may result in a greater risk for developing stress and depression. Outdoor nature-related activities can enhance general well-being. However, the underlying mechanisms are not fully delineate...

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Autores principales:	Tanja Sobko, Suisha Liang, Will H. G. Cheng, Hein M. Tun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/15b4a0443cf341beac5ea876c814825b
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spelling	oai:doaj.org-article:15b4a0443cf341beac5ea876c814825b2021-12-02T11:57:57ZImpact of outdoor nature-related activities on gut microbiota, fecal serotonin, and perceived stress in preschool children: the Play&Grow randomized controlled trial10.1038/s41598-020-78642-22045-2322https://doaj.org/article/15b4a0443cf341beac5ea876c814825b2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78642-2https://doaj.org/toc/2045-2322Abstract Due to rapid urbanization, children today have fewer opportunities to interact with nature and this may result in a greater risk for developing stress and depression. Outdoor nature-related activities can enhance general well-being. However, the underlying mechanisms are not fully delineated. Here we recruited 54 preschool children to participate in a 10-week structured nature-related “Play&Grow” program. Following the intervention, children were assessed for connectedness to nature and perceived stress levels using validated questionnaires. Moreover, fecal serotonin level and gut microbiota profiles were measured by ELISA and 16S rDNA amplicon sequencing, respectively. Children were significantly more connected to nature after the intervention. Their gut microbiota altered, especially by modulating the abundance of Roseburia and the fecal-serotonin level. Moreover, we also observed a reduction in the overall perceived stress, particularly in the frequency of anger among these children. This study is the first to demonstrate the impact of nature-related activities on gut microbiota, fecal serotonin and psychosocial behaviour of preschool children. However, further mechanistic studies are needed to confirm the functional role of gut microbiota in the association between connectedness to nature and improved psychosocial behavior.Tanja SobkoSuisha LiangWill H. G. ChengHein M. TunNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tanja Sobko Suisha Liang Will H. G. Cheng Hein M. Tun Impact of outdoor nature-related activities on gut microbiota, fecal serotonin, and perceived stress in preschool children: the Play&Grow randomized controlled trial
description	Abstract Due to rapid urbanization, children today have fewer opportunities to interact with nature and this may result in a greater risk for developing stress and depression. Outdoor nature-related activities can enhance general well-being. However, the underlying mechanisms are not fully delineated. Here we recruited 54 preschool children to participate in a 10-week structured nature-related “Play&Grow” program. Following the intervention, children were assessed for connectedness to nature and perceived stress levels using validated questionnaires. Moreover, fecal serotonin level and gut microbiota profiles were measured by ELISA and 16S rDNA amplicon sequencing, respectively. Children were significantly more connected to nature after the intervention. Their gut microbiota altered, especially by modulating the abundance of Roseburia and the fecal-serotonin level. Moreover, we also observed a reduction in the overall perceived stress, particularly in the frequency of anger among these children. This study is the first to demonstrate the impact of nature-related activities on gut microbiota, fecal serotonin and psychosocial behaviour of preschool children. However, further mechanistic studies are needed to confirm the functional role of gut microbiota in the association between connectedness to nature and improved psychosocial behavior.
format	article
author	Tanja Sobko Suisha Liang Will H. G. Cheng Hein M. Tun
author_facet	Tanja Sobko Suisha Liang Will H. G. Cheng Hein M. Tun
author_sort	Tanja Sobko
title	Impact of outdoor nature-related activities on gut microbiota, fecal serotonin, and perceived stress in preschool children: the Play&Grow randomized controlled trial
title_short	Impact of outdoor nature-related activities on gut microbiota, fecal serotonin, and perceived stress in preschool children: the Play&Grow randomized controlled trial
title_full	Impact of outdoor nature-related activities on gut microbiota, fecal serotonin, and perceived stress in preschool children: the Play&Grow randomized controlled trial
title_fullStr	Impact of outdoor nature-related activities on gut microbiota, fecal serotonin, and perceived stress in preschool children: the Play&Grow randomized controlled trial
title_full_unstemmed	Impact of outdoor nature-related activities on gut microbiota, fecal serotonin, and perceived stress in preschool children: the Play&Grow randomized controlled trial
title_sort	impact of outdoor nature-related activities on gut microbiota, fecal serotonin, and perceived stress in preschool children: the play&grow randomized controlled trial
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/15b4a0443cf341beac5ea876c814825b
work_keys_str_mv	AT tanjasobko impactofoutdoornaturerelatedactivitiesongutmicrobiotafecalserotoninandperceivedstressinpreschoolchildrentheplaygrowrandomizedcontrolledtrial AT suishaliang impactofoutdoornaturerelatedactivitiesongutmicrobiotafecalserotoninandperceivedstressinpreschoolchildrentheplaygrowrandomizedcontrolledtrial AT willhgcheng impactofoutdoornaturerelatedactivitiesongutmicrobiotafecalserotoninandperceivedstressinpreschoolchildrentheplaygrowrandomizedcontrolledtrial AT heinmtun impactofoutdoornaturerelatedactivitiesongutmicrobiotafecalserotoninandperceivedstressinpreschoolchildrentheplaygrowrandomizedcontrolledtrial
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Impact of outdoor nature-related activities on gut microbiota, fecal serotonin, and perceived stress in preschool children: the Play&Grow randomized controlled trial

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