The 3' region of the chicken hypersensitive site-4 insulator has properties similar to its core and is required for full insulator activity.

The 3' region of the chicken hypersensitive site-4 insulator has properties similar to its core and is required for full insulator activity.

Chromatin insulators separate active transcriptional domains and block the spread of heterochromatin in the genome. Studies on the chicken hypersensitive site-4 (cHS4) element, a prototypic insulator, have identified CTCF and USF-1/2 motifs in the proximal 250 bp of cHS4, termed the "core"...

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Autores principales: Paritha I Arumugam, Fabrizia Urbinati, Chinavenmeni S Velu, Tomoyasu Higashimoto, H Leighton Grimes, Punam Malik
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2009
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/15b5776a3d7144058cef5583685da0d2
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