AA amyloid fibrils from diseased tissue are structurally different from in vitro formed SAA fibrils

Systemic AA amyloidosis is a protein misfolding disease caused by the formation of amyloid fibrils from serum amyloid A (SAA) protein. Here, the authors present the cryo-EM structures of AA amyloid fibrils isolated from mouse tissue and in vitro formed fibrils, which differ in their structures and t...

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Autores principales:	Akanksha Bansal, Matthias Schmidt, Matthies Rennegarbe, Christian Haupt, Falk Liberta, Sabrina Stecher, Ioana Puscalau-Girtu, Alexander Biedermann, Marcus Fändrich
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/15b5d0653a7f4fee9b6e4b37a7961e1e
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spelling	oai:doaj.org-article:15b5d0653a7f4fee9b6e4b37a7961e1e2021-12-02T14:10:56ZAA amyloid fibrils from diseased tissue are structurally different from in vitro formed SAA fibrils10.1038/s41467-021-21129-z2041-1723https://doaj.org/article/15b5d0653a7f4fee9b6e4b37a7961e1e2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21129-zhttps://doaj.org/toc/2041-1723Systemic AA amyloidosis is a protein misfolding disease caused by the formation of amyloid fibrils from serum amyloid A (SAA) protein. Here, the authors present the cryo-EM structures of AA amyloid fibrils isolated from mouse tissue and in vitro formed fibrils, which differ in their structures and they also show that the ex vivo fibrils are more resistant to proteolysis than the in vitro fibrils and propose that pathogenic amyloid fibrils might originate from proteolytic selection.Akanksha BansalMatthias SchmidtMatthies RennegarbeChristian HauptFalk LibertaSabrina StecherIoana Puscalau-GirtuAlexander BiedermannMarcus FändrichNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Akanksha Bansal Matthias Schmidt Matthies Rennegarbe Christian Haupt Falk Liberta Sabrina Stecher Ioana Puscalau-Girtu Alexander Biedermann Marcus Fändrich AA amyloid fibrils from diseased tissue are structurally different from in vitro formed SAA fibrils
description	Systemic AA amyloidosis is a protein misfolding disease caused by the formation of amyloid fibrils from serum amyloid A (SAA) protein. Here, the authors present the cryo-EM structures of AA amyloid fibrils isolated from mouse tissue and in vitro formed fibrils, which differ in their structures and they also show that the ex vivo fibrils are more resistant to proteolysis than the in vitro fibrils and propose that pathogenic amyloid fibrils might originate from proteolytic selection.
format	article
author	Akanksha Bansal Matthias Schmidt Matthies Rennegarbe Christian Haupt Falk Liberta Sabrina Stecher Ioana Puscalau-Girtu Alexander Biedermann Marcus Fändrich
author_facet	Akanksha Bansal Matthias Schmidt Matthies Rennegarbe Christian Haupt Falk Liberta Sabrina Stecher Ioana Puscalau-Girtu Alexander Biedermann Marcus Fändrich
author_sort	Akanksha Bansal
title	AA amyloid fibrils from diseased tissue are structurally different from in vitro formed SAA fibrils
title_short	AA amyloid fibrils from diseased tissue are structurally different from in vitro formed SAA fibrils
title_full	AA amyloid fibrils from diseased tissue are structurally different from in vitro formed SAA fibrils
title_fullStr	AA amyloid fibrils from diseased tissue are structurally different from in vitro formed SAA fibrils
title_full_unstemmed	AA amyloid fibrils from diseased tissue are structurally different from in vitro formed SAA fibrils
title_sort	aa amyloid fibrils from diseased tissue are structurally different from in vitro formed saa fibrils
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/15b5d0653a7f4fee9b6e4b37a7961e1e
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AA amyloid fibrils from diseased tissue are structurally different from in vitro formed SAA fibrils

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