AA amyloid fibrils from diseased tissue are structurally different from in vitro formed SAA fibrils

Systemic AA amyloidosis is a protein misfolding disease caused by the formation of amyloid fibrils from serum amyloid A (SAA) protein. Here, the authors present the cryo-EM structures of AA amyloid fibrils isolated from mouse tissue and in vitro formed fibrils, which differ in their structures and t...

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Autores principales: Akanksha Bansal, Matthias Schmidt, Matthies Rennegarbe, Christian Haupt, Falk Liberta, Sabrina Stecher, Ioana Puscalau-Girtu, Alexander Biedermann, Marcus Fändrich
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/15b5d0653a7f4fee9b6e4b37a7961e1e
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