Metabolic characteristics and therapeutic potential of brown and ?beige? adipose tissues

According to the International Diabetes Federation, 10.9 million people have diabetes mellitus (DM) in Russia; however, only up to 4 million are registered. In addition, 11.9 million people have impaired glucose tolerance and impaired fasting glucose levels [1]. One of the significant risk factors f...

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Autores principales:	Ekaterina Olegovna Koksharova, Alexander Yur'evich Mayorov, Marina Vladimirovna Shestakova, Ivan Ivanovich Dedov
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2014
Materias:	insulin resistance type 2 diabetes brown adipose tissue ?beige? adipose tissue Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/15b6445a6cb6458498fc7e33de1b994e
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id	oai:doaj.org-article:15b6445a6cb6458498fc7e33de1b994e
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spelling	oai:doaj.org-article:15b6445a6cb6458498fc7e33de1b994e2021-11-14T09:00:19ZMetabolic characteristics and therapeutic potential of brown and ?beige? adipose tissues2072-03512072-037810.14341/DM201445-15https://doaj.org/article/15b6445a6cb6458498fc7e33de1b994e2014-12-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/6769https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378According to the International Diabetes Federation, 10.9 million people have diabetes mellitus (DM) in Russia; however, only up to 4 million are registered. In addition, 11.9 million people have impaired glucose tolerance and impaired fasting glucose levels [1]. One of the significant risk factors for type 2 DM (T2DM) is obesity, which increases insulin resistance (IR). IR is the major pathogenetic link to T2DM. According to current concepts, there are three types of adipose tissue: white adipose tissue (WAT), brown adipose tissue (BAT) and ?beige?, of which the last two types have a thermogenic function. Some research results have revealed the main stages in the development of adipocytes; however, there is no general consensus regarding the development of ?beige? adipocytes. Furthermore, the biology of BAT and ?beige? adipose tissue is currently being intensively investigated, and some key transcription factors, signalling pathways and hormones that promote the development and activation of these tissues have been identified. The most discussed hormones are irisin and fibroblast growth factor 21, which have established positive effects on BAT and ?beige? adipose tissue with regard to carbohydrate, lipid and energy metabolism. The primary imaging techniques used to investigate BAT are PET-CT with 18F-fluorodeoxyglucose and magnetic resonance spectroscopy. With respect to the current obesity epidemic and associated diseases, including T2DM, there is a growing interest in investigating adipogenesis and the possibility of altering this process. BAT and ?beige? adipose tissue may be targets for developing drugs directed against obesity and T2DM.Ekaterina Olegovna KoksharovaAlexander Yur'evich MayorovMarina Vladimirovna ShestakovaIvan Ivanovich DedovEndocrinology Research Centrearticleinsulin resistancetype 2 diabetesbrown adipose tissue?beige? adipose tissueNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 17, Iss 4, Pp 5-15 (2014)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	insulin resistance type 2 diabetes brown adipose tissue ?beige? adipose tissue Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	insulin resistance type 2 diabetes brown adipose tissue ?beige? adipose tissue Nutritional diseases. Deficiency diseases RC620-627 Ekaterina Olegovna Koksharova Alexander Yur'evich Mayorov Marina Vladimirovna Shestakova Ivan Ivanovich Dedov Metabolic characteristics and therapeutic potential of brown and ?beige? adipose tissues
description	According to the International Diabetes Federation, 10.9 million people have diabetes mellitus (DM) in Russia; however, only up to 4 million are registered. In addition, 11.9 million people have impaired glucose tolerance and impaired fasting glucose levels [1]. One of the significant risk factors for type 2 DM (T2DM) is obesity, which increases insulin resistance (IR). IR is the major pathogenetic link to T2DM. According to current concepts, there are three types of adipose tissue: white adipose tissue (WAT), brown adipose tissue (BAT) and ?beige?, of which the last two types have a thermogenic function. Some research results have revealed the main stages in the development of adipocytes; however, there is no general consensus regarding the development of ?beige? adipocytes. Furthermore, the biology of BAT and ?beige? adipose tissue is currently being intensively investigated, and some key transcription factors, signalling pathways and hormones that promote the development and activation of these tissues have been identified. The most discussed hormones are irisin and fibroblast growth factor 21, which have established positive effects on BAT and ?beige? adipose tissue with regard to carbohydrate, lipid and energy metabolism. The primary imaging techniques used to investigate BAT are PET-CT with 18F-fluorodeoxyglucose and magnetic resonance spectroscopy. With respect to the current obesity epidemic and associated diseases, including T2DM, there is a growing interest in investigating adipogenesis and the possibility of altering this process. BAT and ?beige? adipose tissue may be targets for developing drugs directed against obesity and T2DM.
format	article
author	Ekaterina Olegovna Koksharova Alexander Yur'evich Mayorov Marina Vladimirovna Shestakova Ivan Ivanovich Dedov
author_facet	Ekaterina Olegovna Koksharova Alexander Yur'evich Mayorov Marina Vladimirovna Shestakova Ivan Ivanovich Dedov
author_sort	Ekaterina Olegovna Koksharova
title	Metabolic characteristics and therapeutic potential of brown and ?beige? adipose tissues
title_short	Metabolic characteristics and therapeutic potential of brown and ?beige? adipose tissues
title_full	Metabolic characteristics and therapeutic potential of brown and ?beige? adipose tissues
title_fullStr	Metabolic characteristics and therapeutic potential of brown and ?beige? adipose tissues
title_full_unstemmed	Metabolic characteristics and therapeutic potential of brown and ?beige? adipose tissues
title_sort	metabolic characteristics and therapeutic potential of brown and ?beige? adipose tissues
publisher	Endocrinology Research Centre
publishDate	2014
url	https://doaj.org/article/15b6445a6cb6458498fc7e33de1b994e
work_keys_str_mv	AT ekaterinaolegovnakoksharova metaboliccharacteristicsandtherapeuticpotentialofbrownandbeigeadiposetissues AT alexanderyurevichmayorov metaboliccharacteristicsandtherapeuticpotentialofbrownandbeigeadiposetissues AT marinavladimirovnashestakova metaboliccharacteristicsandtherapeuticpotentialofbrownandbeigeadiposetissues AT ivanivanovichdedov metaboliccharacteristicsandtherapeuticpotentialofbrownandbeigeadiposetissues
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Metabolic characteristics and therapeutic potential of brown and ?beige? adipose tissues

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