HPV Type Distribution in HIV Positive and Negative Women With or Without Cervical Dysplasia or Cancer in East Africa
BackgroundWomen living with HIV in sub-Saharan Africa are at increased risk to develop cervical cancer (CC), which is caused by persistent infection with 13 oncogenic human papilloma viruses (HR-HPVs). It is important to accurately identify and target HIV-positive women at highest risk to develop CC...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:15bddb881e4d4fdc8d763d693956f2e82021-12-01T15:47:56ZHPV Type Distribution in HIV Positive and Negative Women With or Without Cervical Dysplasia or Cancer in East Africa2234-943X10.3389/fonc.2021.763717https://doaj.org/article/15bddb881e4d4fdc8d763d693956f2e82021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.763717/fullhttps://doaj.org/toc/2234-943XBackgroundWomen living with HIV in sub-Saharan Africa are at increased risk to develop cervical cancer (CC), which is caused by persistent infection with 13 oncogenic human papilloma viruses (HR-HPVs). It is important to accurately identify and target HIV-positive women at highest risk to develop CC for early therapeutic intervention.MethodsA total of 2,134 HIV+ and HIV− women from South-West Tanzania were prospectively screened for cervical cancer and precancerous lesions. Women with cervical cancer (n=236), high- and low-grade squamous intraepithelial lesions (HSIL: n=68, LSIL: n=74), and without lesion (n=426) underwent high-resolution HPV genotyping.ResultsEighty percent of women who were diagnosed with HSIL or LSIL were living with HIV. Any lesion, young age, HIV status, and depleted CD4 T cell counts were independent risk factors for HPV infections, which were predominantly caused by HR-HPV types. While multiple HR-HPV type infections were predominant in HIV+ women with HSIL, single-type infections predominated in HIV+ CC cases (p=0.0006). HPV16, 18, and 45 accounted for 85% (68/80) and 75% (82/110) of HIV+ and HIV− CC cases, respectively. Of note, HPV35, the most frequent HPV type in HSIL-positive women living with HIV, was rarely detected as a single-type infection in HSIL and cancer cases.ConclusionHPV16, 18, and 45 should receive special attention for molecular diagnostic algorithms during CC prevention programs for HIV+ women from sub-Saharan Africa. HPV35 may have a high potential to induce HSIL in women living with HIV, but less potential to cause cervical cancer in single-type infections.Ruby McharoTessa LennemannTessa LennemannJohn FranceLiseth TorresMercè GaríWilbert MbuyaWilbert MbuyaWolfram MwalongoAnifrid MahengeAsli BauerAsli BauerJonathan MnkaiLaura GlasmeyerMona JudickMatilda PaulNicolas SchroederBareke MsombaMagreth SemboNhamo ChiwerengoMichael HoelscherMichael HoelscherOtto GeisenbergerOtto GeisenbergerRalph J. LelleElmar SaathoffElmar SaathoffLeonard MabokoMkunde ChachageMkunde ChachageMkunde ChachageArne KroidlArne KroidlChristof GeldmacherChristof GeldmacherFrontiers Media S.A.articlehuman papilloma virus—HPVhuman immunodeficiency virus—HIVcervical cancercervical dysplasiahigh-grade intraepithelial lesionslow-grade intraepithelial lesionsNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021) |
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human papilloma virus—HPV human immunodeficiency virus—HIV cervical cancer cervical dysplasia high-grade intraepithelial lesions low-grade intraepithelial lesions Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
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human papilloma virus—HPV human immunodeficiency virus—HIV cervical cancer cervical dysplasia high-grade intraepithelial lesions low-grade intraepithelial lesions Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Ruby Mcharo Tessa Lennemann Tessa Lennemann John France Liseth Torres Mercè Garí Wilbert Mbuya Wilbert Mbuya Wolfram Mwalongo Anifrid Mahenge Asli Bauer Asli Bauer Jonathan Mnkai Laura Glasmeyer Mona Judick Matilda Paul Nicolas Schroeder Bareke Msomba Magreth Sembo Nhamo Chiwerengo Michael Hoelscher Michael Hoelscher Otto Geisenberger Otto Geisenberger Ralph J. Lelle Elmar Saathoff Elmar Saathoff Leonard Maboko Mkunde Chachage Mkunde Chachage Mkunde Chachage Arne Kroidl Arne Kroidl Christof Geldmacher Christof Geldmacher HPV Type Distribution in HIV Positive and Negative Women With or Without Cervical Dysplasia or Cancer in East Africa |
| description |
BackgroundWomen living with HIV in sub-Saharan Africa are at increased risk to develop cervical cancer (CC), which is caused by persistent infection with 13 oncogenic human papilloma viruses (HR-HPVs). It is important to accurately identify and target HIV-positive women at highest risk to develop CC for early therapeutic intervention.MethodsA total of 2,134 HIV+ and HIV− women from South-West Tanzania were prospectively screened for cervical cancer and precancerous lesions. Women with cervical cancer (n=236), high- and low-grade squamous intraepithelial lesions (HSIL: n=68, LSIL: n=74), and without lesion (n=426) underwent high-resolution HPV genotyping.ResultsEighty percent of women who were diagnosed with HSIL or LSIL were living with HIV. Any lesion, young age, HIV status, and depleted CD4 T cell counts were independent risk factors for HPV infections, which were predominantly caused by HR-HPV types. While multiple HR-HPV type infections were predominant in HIV+ women with HSIL, single-type infections predominated in HIV+ CC cases (p=0.0006). HPV16, 18, and 45 accounted for 85% (68/80) and 75% (82/110) of HIV+ and HIV− CC cases, respectively. Of note, HPV35, the most frequent HPV type in HSIL-positive women living with HIV, was rarely detected as a single-type infection in HSIL and cancer cases.ConclusionHPV16, 18, and 45 should receive special attention for molecular diagnostic algorithms during CC prevention programs for HIV+ women from sub-Saharan Africa. HPV35 may have a high potential to induce HSIL in women living with HIV, but less potential to cause cervical cancer in single-type infections. |
| format |
article |
| author |
Ruby Mcharo Tessa Lennemann Tessa Lennemann John France Liseth Torres Mercè Garí Wilbert Mbuya Wilbert Mbuya Wolfram Mwalongo Anifrid Mahenge Asli Bauer Asli Bauer Jonathan Mnkai Laura Glasmeyer Mona Judick Matilda Paul Nicolas Schroeder Bareke Msomba Magreth Sembo Nhamo Chiwerengo Michael Hoelscher Michael Hoelscher Otto Geisenberger Otto Geisenberger Ralph J. Lelle Elmar Saathoff Elmar Saathoff Leonard Maboko Mkunde Chachage Mkunde Chachage Mkunde Chachage Arne Kroidl Arne Kroidl Christof Geldmacher Christof Geldmacher |
| author_facet |
Ruby Mcharo Tessa Lennemann Tessa Lennemann John France Liseth Torres Mercè Garí Wilbert Mbuya Wilbert Mbuya Wolfram Mwalongo Anifrid Mahenge Asli Bauer Asli Bauer Jonathan Mnkai Laura Glasmeyer Mona Judick Matilda Paul Nicolas Schroeder Bareke Msomba Magreth Sembo Nhamo Chiwerengo Michael Hoelscher Michael Hoelscher Otto Geisenberger Otto Geisenberger Ralph J. Lelle Elmar Saathoff Elmar Saathoff Leonard Maboko Mkunde Chachage Mkunde Chachage Mkunde Chachage Arne Kroidl Arne Kroidl Christof Geldmacher Christof Geldmacher |
| author_sort |
Ruby Mcharo |
| title |
HPV Type Distribution in HIV Positive and Negative Women With or Without Cervical Dysplasia or Cancer in East Africa |
| title_short |
HPV Type Distribution in HIV Positive and Negative Women With or Without Cervical Dysplasia or Cancer in East Africa |
| title_full |
HPV Type Distribution in HIV Positive and Negative Women With or Without Cervical Dysplasia or Cancer in East Africa |
| title_fullStr |
HPV Type Distribution in HIV Positive and Negative Women With or Without Cervical Dysplasia or Cancer in East Africa |
| title_full_unstemmed |
HPV Type Distribution in HIV Positive and Negative Women With or Without Cervical Dysplasia or Cancer in East Africa |
| title_sort |
hpv type distribution in hiv positive and negative women with or without cervical dysplasia or cancer in east africa |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/15bddb881e4d4fdc8d763d693956f2e8 |
| work_keys_str_mv |
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