Selection for replicases in protocells.

We consider a world of nucleotide sequences and protocells. The sequences have the property of spontaneous self-replication. Some sequences - so-called replicases - have enzymatic activity in the sense of enhancing the replication rate of all (or almost all) sequences. In a well-mixed medium, natura...

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Autores principales:	Ginestra Bianconi, Kun Zhao, Irene A Chen, Martin A Nowak
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/15c8802f1de5472eb275140e52c37fd0
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id	oai:doaj.org-article:15c8802f1de5472eb275140e52c37fd0
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spelling	oai:doaj.org-article:15c8802f1de5472eb275140e52c37fd02021-11-18T05:52:10ZSelection for replicases in protocells.1553-734X1553-735810.1371/journal.pcbi.1003051https://doaj.org/article/15c8802f1de5472eb275140e52c37fd02013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23671413/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358We consider a world of nucleotide sequences and protocells. The sequences have the property of spontaneous self-replication. Some sequences - so-called replicases - have enzymatic activity in the sense of enhancing the replication rate of all (or almost all) sequences. In a well-mixed medium, natural selection would not favor such replicases because their presence equally benefits sequences with or without replicase activity. Here we show that protocells can select for replicases. We assume that sequences replicate within protocells and that protocells undergo spontaneous division. This leads to particular population structures which can augment the abundance of replicases. We explore various assumptions regarding replicase activity and protocell division. We calculate the error threshold that is compatible with selecting for replicases.Ginestra BianconiKun ZhaoIrene A ChenMartin A NowakPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 9, Iss 5, p e1003051 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Ginestra Bianconi Kun Zhao Irene A Chen Martin A Nowak Selection for replicases in protocells.
description	We consider a world of nucleotide sequences and protocells. The sequences have the property of spontaneous self-replication. Some sequences - so-called replicases - have enzymatic activity in the sense of enhancing the replication rate of all (or almost all) sequences. In a well-mixed medium, natural selection would not favor such replicases because their presence equally benefits sequences with or without replicase activity. Here we show that protocells can select for replicases. We assume that sequences replicate within protocells and that protocells undergo spontaneous division. This leads to particular population structures which can augment the abundance of replicases. We explore various assumptions regarding replicase activity and protocell division. We calculate the error threshold that is compatible with selecting for replicases.
format	article
author	Ginestra Bianconi Kun Zhao Irene A Chen Martin A Nowak
author_facet	Ginestra Bianconi Kun Zhao Irene A Chen Martin A Nowak
author_sort	Ginestra Bianconi
title	Selection for replicases in protocells.
title_short	Selection for replicases in protocells.
title_full	Selection for replicases in protocells.
title_fullStr	Selection for replicases in protocells.
title_full_unstemmed	Selection for replicases in protocells.
title_sort	selection for replicases in protocells.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/15c8802f1de5472eb275140e52c37fd0
work_keys_str_mv	AT ginestrabianconi selectionforreplicasesinprotocells AT kunzhao selectionforreplicasesinprotocells AT ireneachen selectionforreplicasesinprotocells AT martinanowak selectionforreplicasesinprotocells
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Selection for replicases in protocells.

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