Resistance training mitigates hepato-cardiac changes and muscle mitochondrial protein reductions in rats with diet-induced obesity

Aim: To investigate the effect of resistance training (RT) on hepatocardiovascular and muscle mitochondrial parameters in rats that were fed a high-calorie diet for 12 weeks. Main methods: The animals were divided into four groups: control (C), exercise (E), obese (O), and obese plus exercise (OE)....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Caroline Pancera Laurindo, Karen C. Rego Gregorio, Ana Caroline Rippi Moreno, Julia Maia Viudes Agostinho, Evelyn Carvalho Campos, Gisele Alborghetti Nai, Maria Tereza Nunes, Patrícia Monteiro Seraphim
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Obesity Resistance training Mitochondrial biogenesis Hepato-cardiac alterations Science (General) Q1-390 Social sciences (General) H1-99
Acceso en línea:	https://doaj.org/article/15c8bfda3fa342e49b64a83f83e876c9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:15c8bfda3fa342e49b64a83f83e876c9
record_format	dspace
spelling	oai:doaj.org-article:15c8bfda3fa342e49b64a83f83e876c92021-12-02T05:02:54ZResistance training mitigates hepato-cardiac changes and muscle mitochondrial protein reductions in rats with diet-induced obesity2405-844010.1016/j.heliyon.2021.e08374https://doaj.org/article/15c8bfda3fa342e49b64a83f83e876c92021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2405844021024774https://doaj.org/toc/2405-8440Aim: To investigate the effect of resistance training (RT) on hepatocardiovascular and muscle mitochondrial parameters in rats that were fed a high-calorie diet for 12 weeks. Main methods: The animals were divided into four groups: control (C), exercise (E), obese (O), and obese plus exercise (OE). Group E and OE rats performed resistance training by climbing on a vertical ladder with load attached to the end of the tail (1×/day, 3×/week, for 12 weeks). Group O and OE rats were fed a high-calorie diet containing chow and a cafeteria diet for 12 weeks. Under anesthesia, the heart and liver were removed for histopathological analysis, and the gastrocnemius muscle was removed for Western blotting. Key findings: Group O rats were heavier, with increased fat mass, elevated fasting glycemia, and total triglycerides, and exhibited a significant number of Kupffer cells and diffuse steatosis in the liver. Group O rats also showed increased thickness of the right ventricle, septum, and pulmonary artery. All of these parameters were attenuated by RT. PGC1-α protein levels were increased in both exercise groups. The protein levels of OXPHOS complexes III, IV, and V were reduced in Group O, while RT prevented this alteration. Significance: RT exerts a protective effect against hepato-cardiac alterations and prevents changes in the muscle mitochondrial protein profile induced by a high-calorie diet.Caroline Pancera LaurindoKaren C. Rego GregorioAna Caroline Rippi MorenoJulia Maia Viudes AgostinhoEvelyn Carvalho CamposGisele Alborghetti NaiMaria Tereza NunesPatrícia Monteiro SeraphimElsevierarticleObesityResistance trainingMitochondrial biogenesisHepato-cardiac alterationsScience (General)Q1-390Social sciences (General)H1-99ENHeliyon, Vol 7, Iss 11, Pp e08374- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Obesity Resistance training Mitochondrial biogenesis Hepato-cardiac alterations Science (General) Q1-390 Social sciences (General) H1-99
spellingShingle	Obesity Resistance training Mitochondrial biogenesis Hepato-cardiac alterations Science (General) Q1-390 Social sciences (General) H1-99 Caroline Pancera Laurindo Karen C. Rego Gregorio Ana Caroline Rippi Moreno Julia Maia Viudes Agostinho Evelyn Carvalho Campos Gisele Alborghetti Nai Maria Tereza Nunes Patrícia Monteiro Seraphim Resistance training mitigates hepato-cardiac changes and muscle mitochondrial protein reductions in rats with diet-induced obesity
description	Aim: To investigate the effect of resistance training (RT) on hepatocardiovascular and muscle mitochondrial parameters in rats that were fed a high-calorie diet for 12 weeks. Main methods: The animals were divided into four groups: control (C), exercise (E), obese (O), and obese plus exercise (OE). Group E and OE rats performed resistance training by climbing on a vertical ladder with load attached to the end of the tail (1×/day, 3×/week, for 12 weeks). Group O and OE rats were fed a high-calorie diet containing chow and a cafeteria diet for 12 weeks. Under anesthesia, the heart and liver were removed for histopathological analysis, and the gastrocnemius muscle was removed for Western blotting. Key findings: Group O rats were heavier, with increased fat mass, elevated fasting glycemia, and total triglycerides, and exhibited a significant number of Kupffer cells and diffuse steatosis in the liver. Group O rats also showed increased thickness of the right ventricle, septum, and pulmonary artery. All of these parameters were attenuated by RT. PGC1-α protein levels were increased in both exercise groups. The protein levels of OXPHOS complexes III, IV, and V were reduced in Group O, while RT prevented this alteration. Significance: RT exerts a protective effect against hepato-cardiac alterations and prevents changes in the muscle mitochondrial protein profile induced by a high-calorie diet.
format	article
author	Caroline Pancera Laurindo Karen C. Rego Gregorio Ana Caroline Rippi Moreno Julia Maia Viudes Agostinho Evelyn Carvalho Campos Gisele Alborghetti Nai Maria Tereza Nunes Patrícia Monteiro Seraphim
author_facet	Caroline Pancera Laurindo Karen C. Rego Gregorio Ana Caroline Rippi Moreno Julia Maia Viudes Agostinho Evelyn Carvalho Campos Gisele Alborghetti Nai Maria Tereza Nunes Patrícia Monteiro Seraphim
author_sort	Caroline Pancera Laurindo
title	Resistance training mitigates hepato-cardiac changes and muscle mitochondrial protein reductions in rats with diet-induced obesity
title_short	Resistance training mitigates hepato-cardiac changes and muscle mitochondrial protein reductions in rats with diet-induced obesity
title_full	Resistance training mitigates hepato-cardiac changes and muscle mitochondrial protein reductions in rats with diet-induced obesity
title_fullStr	Resistance training mitigates hepato-cardiac changes and muscle mitochondrial protein reductions in rats with diet-induced obesity
title_full_unstemmed	Resistance training mitigates hepato-cardiac changes and muscle mitochondrial protein reductions in rats with diet-induced obesity
title_sort	resistance training mitigates hepato-cardiac changes and muscle mitochondrial protein reductions in rats with diet-induced obesity
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/15c8bfda3fa342e49b64a83f83e876c9
work_keys_str_mv	AT carolinepanceralaurindo resistancetrainingmitigateshepatocardiacchangesandmusclemitochondrialproteinreductionsinratswithdietinducedobesity AT karencregogregorio resistancetrainingmitigateshepatocardiacchangesandmusclemitochondrialproteinreductionsinratswithdietinducedobesity AT anacarolinerippimoreno resistancetrainingmitigateshepatocardiacchangesandmusclemitochondrialproteinreductionsinratswithdietinducedobesity AT juliamaiaviudesagostinho resistancetrainingmitigateshepatocardiacchangesandmusclemitochondrialproteinreductionsinratswithdietinducedobesity AT evelyncarvalhocampos resistancetrainingmitigateshepatocardiacchangesandmusclemitochondrialproteinreductionsinratswithdietinducedobesity AT giselealborghettinai resistancetrainingmitigateshepatocardiacchangesandmusclemitochondrialproteinreductionsinratswithdietinducedobesity AT mariaterezanunes resistancetrainingmitigateshepatocardiacchangesandmusclemitochondrialproteinreductionsinratswithdietinducedobesity AT patriciamonteiroseraphim resistancetrainingmitigateshepatocardiacchangesandmusclemitochondrialproteinreductionsinratswithdietinducedobesity
_version_	1718400693762523136

Resistance training mitigates hepato-cardiac changes and muscle mitochondrial protein reductions in rats with diet-induced obesity

Ejemplares similares