Synaptic pathology in Huntington's disease: Beyond the corticostriatal pathway
Huntington's disease (HD) is a heritable, fatal neurodegenerative disorder caused by a mutation in the Huntingtin gene. It is characterized by chorea, as well as cognitive and psychiatric symptoms. Histopathologically, there is a massive loss of striatal projection neurons and less but signific...
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2022
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oai:doaj.org-article:15c95e1409ae43cdaff29b2eb915034a2021-12-02T04:59:16ZSynaptic pathology in Huntington's disease: Beyond the corticostriatal pathway1095-953X10.1016/j.nbd.2021.105574https://doaj.org/article/15c95e1409ae43cdaff29b2eb915034a2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0969996121003235https://doaj.org/toc/1095-953XHuntington's disease (HD) is a heritable, fatal neurodegenerative disorder caused by a mutation in the Huntingtin gene. It is characterized by chorea, as well as cognitive and psychiatric symptoms. Histopathologically, there is a massive loss of striatal projection neurons and less but significant loss in other areas throughout the cortico-basal ganglia-thalamocortical (CBGTC) loop. The mutant huntingtin protein has been implicated in numerous functions, including an important role in synaptic transmission. Most studies on anatomical and physiological alterations in HD have focused on striatum and cerebral cortex. However, based on recent CBGTC projectome evidence, the need to study other pathways has become increasingly clear. In this review, we examine the current status of our knowledge of morphological and electrophysiological alterations of those pathways in animal models of HD. Based on recent studies, there is accumulating evidence that synaptic disconnection, particularly along excitatory pathways, is pervasive and almost universal in HD, thus supporting a critical role of the huntingtin protein in synaptic transmission.Joshua BarryMinh T.N. BuiMichael S. LevineCarlos CepedaElsevierarticleHuntington's diseaseGenetic modelsBasal gangliaSynaptic activityDisconnectionNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENNeurobiology of Disease, Vol 162, Iss , Pp 105574- (2022) |
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Huntington's disease Genetic models Basal ganglia Synaptic activity Disconnection Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 |
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Huntington's disease Genetic models Basal ganglia Synaptic activity Disconnection Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Joshua Barry Minh T.N. Bui Michael S. Levine Carlos Cepeda Synaptic pathology in Huntington's disease: Beyond the corticostriatal pathway |
description |
Huntington's disease (HD) is a heritable, fatal neurodegenerative disorder caused by a mutation in the Huntingtin gene. It is characterized by chorea, as well as cognitive and psychiatric symptoms. Histopathologically, there is a massive loss of striatal projection neurons and less but significant loss in other areas throughout the cortico-basal ganglia-thalamocortical (CBGTC) loop. The mutant huntingtin protein has been implicated in numerous functions, including an important role in synaptic transmission. Most studies on anatomical and physiological alterations in HD have focused on striatum and cerebral cortex. However, based on recent CBGTC projectome evidence, the need to study other pathways has become increasingly clear. In this review, we examine the current status of our knowledge of morphological and electrophysiological alterations of those pathways in animal models of HD. Based on recent studies, there is accumulating evidence that synaptic disconnection, particularly along excitatory pathways, is pervasive and almost universal in HD, thus supporting a critical role of the huntingtin protein in synaptic transmission. |
format |
article |
author |
Joshua Barry Minh T.N. Bui Michael S. Levine Carlos Cepeda |
author_facet |
Joshua Barry Minh T.N. Bui Michael S. Levine Carlos Cepeda |
author_sort |
Joshua Barry |
title |
Synaptic pathology in Huntington's disease: Beyond the corticostriatal pathway |
title_short |
Synaptic pathology in Huntington's disease: Beyond the corticostriatal pathway |
title_full |
Synaptic pathology in Huntington's disease: Beyond the corticostriatal pathway |
title_fullStr |
Synaptic pathology in Huntington's disease: Beyond the corticostriatal pathway |
title_full_unstemmed |
Synaptic pathology in Huntington's disease: Beyond the corticostriatal pathway |
title_sort |
synaptic pathology in huntington's disease: beyond the corticostriatal pathway |
publisher |
Elsevier |
publishDate |
2022 |
url |
https://doaj.org/article/15c95e1409ae43cdaff29b2eb915034a |
work_keys_str_mv |
AT joshuabarry synapticpathologyinhuntingtonsdiseasebeyondthecorticostriatalpathway AT minhtnbui synapticpathologyinhuntingtonsdiseasebeyondthecorticostriatalpathway AT michaelslevine synapticpathologyinhuntingtonsdiseasebeyondthecorticostriatalpathway AT carloscepeda synapticpathologyinhuntingtonsdiseasebeyondthecorticostriatalpathway |
_version_ |
1718400875089625088 |