The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation

Hyperactivation of inflammasome-induced IL-1β can cause immunopathology and is a feature of autoinflammatory diseases. Here, the authors show how ubiquitination of IL-1β limits its activity by targeting it for proteasomal degradation and preventing its cleavage by caspase-1.

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Autores principales:	Swarna L. Vijayaraj, Rebecca Feltham, Maryam Rashidi, Daniel Frank, Zhengyang Liu, Daniel S. Simpson, Gregor Ebert, Angelina Vince, Marco J. Herold, Andrew Kueh, Jaclyn S. Pearson, Laura F. Dagley, James M. Murphy, Andrew I. Webb, Kate E. Lawlor, James E. Vince
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/15cc2871bf48403c8f2afd5582cbe869
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spelling	oai:doaj.org-article:15cc2871bf48403c8f2afd5582cbe8692021-12-02T15:36:29ZThe ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation10.1038/s41467-021-22979-32041-1723https://doaj.org/article/15cc2871bf48403c8f2afd5582cbe8692021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22979-3https://doaj.org/toc/2041-1723Hyperactivation of inflammasome-induced IL-1β can cause immunopathology and is a feature of autoinflammatory diseases. Here, the authors show how ubiquitination of IL-1β limits its activity by targeting it for proteasomal degradation and preventing its cleavage by caspase-1.Swarna L. VijayarajRebecca FelthamMaryam RashidiDaniel FrankZhengyang LiuDaniel S. SimpsonGregor EbertAngelina VinceMarco J. HeroldAndrew KuehJaclyn S. PearsonLaura F. DagleyJames M. MurphyAndrew I. WebbKate E. LawlorJames E. VinceNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Swarna L. Vijayaraj Rebecca Feltham Maryam Rashidi Daniel Frank Zhengyang Liu Daniel S. Simpson Gregor Ebert Angelina Vince Marco J. Herold Andrew Kueh Jaclyn S. Pearson Laura F. Dagley James M. Murphy Andrew I. Webb Kate E. Lawlor James E. Vince The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation
description	Hyperactivation of inflammasome-induced IL-1β can cause immunopathology and is a feature of autoinflammatory diseases. Here, the authors show how ubiquitination of IL-1β limits its activity by targeting it for proteasomal degradation and preventing its cleavage by caspase-1.
format	article
author	Swarna L. Vijayaraj Rebecca Feltham Maryam Rashidi Daniel Frank Zhengyang Liu Daniel S. Simpson Gregor Ebert Angelina Vince Marco J. Herold Andrew Kueh Jaclyn S. Pearson Laura F. Dagley James M. Murphy Andrew I. Webb Kate E. Lawlor James E. Vince
author_facet	Swarna L. Vijayaraj Rebecca Feltham Maryam Rashidi Daniel Frank Zhengyang Liu Daniel S. Simpson Gregor Ebert Angelina Vince Marco J. Herold Andrew Kueh Jaclyn S. Pearson Laura F. Dagley James M. Murphy Andrew I. Webb Kate E. Lawlor James E. Vince
author_sort	Swarna L. Vijayaraj
title	The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation
title_short	The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation
title_full	The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation
title_fullStr	The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation
title_full_unstemmed	The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation
title_sort	ubiquitylation of il-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/15cc2871bf48403c8f2afd5582cbe869
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The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation

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