The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation

The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation

Hyperactivation of inflammasome-induced IL-1β can cause immunopathology and is a feature of autoinflammatory diseases. Here, the authors show how ubiquitination of IL-1β limits its activity by targeting it for proteasomal degradation and preventing its cleavage by caspase-1.

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Bibliographic Details
Main Authors: Swarna L. Vijayaraj, Rebecca Feltham, Maryam Rashidi, Daniel Frank, Zhengyang Liu, Daniel S. Simpson, Gregor Ebert, Angelina Vince, Marco J. Herold, Andrew Kueh, Jaclyn S. Pearson, Laura F. Dagley, James M. Murphy, Andrew I. Webb, Kate E. Lawlor, James E. Vince
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Science
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Online Access:https://doaj.org/article/15cc2871bf48403c8f2afd5582cbe869
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Internet

https://doaj.org/article/15cc2871bf48403c8f2afd5582cbe869

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