Tri-Ponderal Mass Index Reference Values for Screening Metabolic Syndrome in Children and Adolescents: Results From Two National-Representative Cross-Sectional Studies in China and America

IntroductionTo ascertain the possible cut point of tri-ponderal mass index (TMI) in discriminating metabolic syndrome (MetS) and related cardio-metabolic risk factors in Chinese and American children and adolescents.MethodsA total of 57,201 Chinese children aged 7-18 recruited in 2012 and and 10,441...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xijie Wang, Yanjun Chen, Jun Ma, Bin Dong, Yanhui Dong, Zhiyong Zou, Yinghua Ma, Luke Arnold, Wannian Liang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	tri-ponderal mass index metabolic syndrome child and adolescent health health screening cardiovascular risk Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/15cd70790cbe4195927019a23564824d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:15cd70790cbe4195927019a23564824d
record_format	dspace
spelling	oai:doaj.org-article:15cd70790cbe4195927019a23564824d2021-11-08T06:56:10ZTri-Ponderal Mass Index Reference Values for Screening Metabolic Syndrome in Children and Adolescents: Results From Two National-Representative Cross-Sectional Studies in China and America1664-239210.3389/fendo.2021.739277https://doaj.org/article/15cd70790cbe4195927019a23564824d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.739277/fullhttps://doaj.org/toc/1664-2392IntroductionTo ascertain the possible cut point of tri-ponderal mass index (TMI) in discriminating metabolic syndrome (MetS) and related cardio-metabolic risk factors in Chinese and American children and adolescents.MethodsA total of 57,201 Chinese children aged 7-18 recruited in 2012 and and 10,441 American children aged 12-18 from National Health and Nutrition Examination Survey (NHANES 2001-2014) were included to fit TMI percentiles. Participants were randomly assigned to a derivation set (75%) and validation set (25%). The cut points of TMI with the lowest misclassification rate under the premise of the highest area under curves (AUC) were selected for each sex, which were additionally examined in the validation set. All of data analysis was conducted between September and December in 2019.ResultsTMI showed good capacity on discriminating MetS, with AUC of 0.7658 (95% CI: 0.7544-0.7770) to 0.8445 (95% CI: 0.8349-0.8537) in Chinese and 0.8871 (95% CI: 0.8663-0.9056) to 0.9329 (95% CI: 0.9166-0.9469) in American children. The optimal cut points were 14.46 kg/m3 and 13.91 kg/m3 for Chinese boys and girls, and 17.08 kg/m3 and 18.89 kg/m3 for American boys and girls, respectively. The corresponding misclassification rates were 17.1% (95% CI: 16.4-17.8) and 11.2% (95% CI: 9.9-12.6), respectively. Performance of these cut points were also examined in the validation set (sensitivity 67.7%, specificity 82.4% in Chinese; sensitivity 84.4%, specificity 88.7% in American children).ConclusionsA sex- and ethnicity- specific single cut point of TMI could be used to distinguish MetS and elevated risk of cardio-metabolic factors in children and adolescents.Xijie WangXijie WangXijie WangYanjun ChenJun MaBin DongYanhui DongZhiyong ZouYinghua MaLuke ArnoldWannian LiangWannian LiangFrontiers Media S.A.articletri-ponderal mass indexmetabolic syndromechild and adolescent healthhealth screeningcardiovascular riskDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	tri-ponderal mass index metabolic syndrome child and adolescent health health screening cardiovascular risk Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	tri-ponderal mass index metabolic syndrome child and adolescent health health screening cardiovascular risk Diseases of the endocrine glands. Clinical endocrinology RC648-665 Xijie Wang Xijie Wang Xijie Wang Yanjun Chen Jun Ma Bin Dong Yanhui Dong Zhiyong Zou Yinghua Ma Luke Arnold Wannian Liang Wannian Liang Tri-Ponderal Mass Index Reference Values for Screening Metabolic Syndrome in Children and Adolescents: Results From Two National-Representative Cross-Sectional Studies in China and America
description	IntroductionTo ascertain the possible cut point of tri-ponderal mass index (TMI) in discriminating metabolic syndrome (MetS) and related cardio-metabolic risk factors in Chinese and American children and adolescents.MethodsA total of 57,201 Chinese children aged 7-18 recruited in 2012 and and 10,441 American children aged 12-18 from National Health and Nutrition Examination Survey (NHANES 2001-2014) were included to fit TMI percentiles. Participants were randomly assigned to a derivation set (75%) and validation set (25%). The cut points of TMI with the lowest misclassification rate under the premise of the highest area under curves (AUC) were selected for each sex, which were additionally examined in the validation set. All of data analysis was conducted between September and December in 2019.ResultsTMI showed good capacity on discriminating MetS, with AUC of 0.7658 (95% CI: 0.7544-0.7770) to 0.8445 (95% CI: 0.8349-0.8537) in Chinese and 0.8871 (95% CI: 0.8663-0.9056) to 0.9329 (95% CI: 0.9166-0.9469) in American children. The optimal cut points were 14.46 kg/m3 and 13.91 kg/m3 for Chinese boys and girls, and 17.08 kg/m3 and 18.89 kg/m3 for American boys and girls, respectively. The corresponding misclassification rates were 17.1% (95% CI: 16.4-17.8) and 11.2% (95% CI: 9.9-12.6), respectively. Performance of these cut points were also examined in the validation set (sensitivity 67.7%, specificity 82.4% in Chinese; sensitivity 84.4%, specificity 88.7% in American children).ConclusionsA sex- and ethnicity- specific single cut point of TMI could be used to distinguish MetS and elevated risk of cardio-metabolic factors in children and adolescents.
format	article
author	Xijie Wang Xijie Wang Xijie Wang Yanjun Chen Jun Ma Bin Dong Yanhui Dong Zhiyong Zou Yinghua Ma Luke Arnold Wannian Liang Wannian Liang
author_facet	Xijie Wang Xijie Wang Xijie Wang Yanjun Chen Jun Ma Bin Dong Yanhui Dong Zhiyong Zou Yinghua Ma Luke Arnold Wannian Liang Wannian Liang
author_sort	Xijie Wang
title	Tri-Ponderal Mass Index Reference Values for Screening Metabolic Syndrome in Children and Adolescents: Results From Two National-Representative Cross-Sectional Studies in China and America
title_short	Tri-Ponderal Mass Index Reference Values for Screening Metabolic Syndrome in Children and Adolescents: Results From Two National-Representative Cross-Sectional Studies in China and America
title_full	Tri-Ponderal Mass Index Reference Values for Screening Metabolic Syndrome in Children and Adolescents: Results From Two National-Representative Cross-Sectional Studies in China and America
title_fullStr	Tri-Ponderal Mass Index Reference Values for Screening Metabolic Syndrome in Children and Adolescents: Results From Two National-Representative Cross-Sectional Studies in China and America
title_full_unstemmed	Tri-Ponderal Mass Index Reference Values for Screening Metabolic Syndrome in Children and Adolescents: Results From Two National-Representative Cross-Sectional Studies in China and America
title_sort	tri-ponderal mass index reference values for screening metabolic syndrome in children and adolescents: results from two national-representative cross-sectional studies in china and america
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/15cd70790cbe4195927019a23564824d
work_keys_str_mv	AT xijiewang triponderalmassindexreferencevaluesforscreeningmetabolicsyndromeinchildrenandadolescentsresultsfromtwonationalrepresentativecrosssectionalstudiesinchinaandamerica AT xijiewang triponderalmassindexreferencevaluesforscreeningmetabolicsyndromeinchildrenandadolescentsresultsfromtwonationalrepresentativecrosssectionalstudiesinchinaandamerica AT xijiewang triponderalmassindexreferencevaluesforscreeningmetabolicsyndromeinchildrenandadolescentsresultsfromtwonationalrepresentativecrosssectionalstudiesinchinaandamerica AT yanjunchen triponderalmassindexreferencevaluesforscreeningmetabolicsyndromeinchildrenandadolescentsresultsfromtwonationalrepresentativecrosssectionalstudiesinchinaandamerica AT junma triponderalmassindexreferencevaluesforscreeningmetabolicsyndromeinchildrenandadolescentsresultsfromtwonationalrepresentativecrosssectionalstudiesinchinaandamerica AT bindong triponderalmassindexreferencevaluesforscreeningmetabolicsyndromeinchildrenandadolescentsresultsfromtwonationalrepresentativecrosssectionalstudiesinchinaandamerica AT yanhuidong triponderalmassindexreferencevaluesforscreeningmetabolicsyndromeinchildrenandadolescentsresultsfromtwonationalrepresentativecrosssectionalstudiesinchinaandamerica AT zhiyongzou triponderalmassindexreferencevaluesforscreeningmetabolicsyndromeinchildrenandadolescentsresultsfromtwonationalrepresentativecrosssectionalstudiesinchinaandamerica AT yinghuama triponderalmassindexreferencevaluesforscreeningmetabolicsyndromeinchildrenandadolescentsresultsfromtwonationalrepresentativecrosssectionalstudiesinchinaandamerica AT lukearnold triponderalmassindexreferencevaluesforscreeningmetabolicsyndromeinchildrenandadolescentsresultsfromtwonationalrepresentativecrosssectionalstudiesinchinaandamerica AT wannianliang triponderalmassindexreferencevaluesforscreeningmetabolicsyndromeinchildrenandadolescentsresultsfromtwonationalrepresentativecrosssectionalstudiesinchinaandamerica AT wannianliang triponderalmassindexreferencevaluesforscreeningmetabolicsyndromeinchildrenandadolescentsresultsfromtwonationalrepresentativecrosssectionalstudiesinchinaandamerica
_version_	1718442881972174848

Tri-Ponderal Mass Index Reference Values for Screening Metabolic Syndrome in Children and Adolescents: Results From Two National-Representative Cross-Sectional Studies in China and America

Ejemplares similares