A framework to guide dose & regimen strategy for clinical drug development

Abstract Optimizing new drug therapies remains a challenge for clinical development, despite the use of ever more sophisticated quantitative methodologies. Although conceptually simple, the idea of finding the right treatment at the right dose for the right patient to ensure an appropriate balance o...

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Autores principales:	Oliver Sander, Baldur Magnusson, Inga Ludwig, Astrid Jullion, Christophe Meille, Daniel Lorand, Björn Bornkamp, Markus Hinder, Steven J. Kovacs, Michael Looby
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/15d1549b9b844cf58ce62297612b8cf4
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spelling	oai:doaj.org-article:15d1549b9b844cf58ce62297612b8cf42021-11-15T18:41:53ZA framework to guide dose & regimen strategy for clinical drug development2163-830610.1002/psp4.12701https://doaj.org/article/15d1549b9b844cf58ce62297612b8cf42021-11-01T00:00:00Zhttps://doi.org/10.1002/psp4.12701https://doaj.org/toc/2163-8306Abstract Optimizing new drug therapies remains a challenge for clinical development, despite the use of ever more sophisticated quantitative methodologies. Although conceptually simple, the idea of finding the right treatment at the right dose for the right patient to ensure an appropriate balance of risks and benefits is challenging and requires a multidisciplinary approach. In this paper, we present a framework developed as a tool for organizing knowledge and facilitating collaboration in development teams.Oliver SanderBaldur MagnussonInga LudwigAstrid JullionChristophe MeilleDaniel LorandBjörn BornkampMarkus HinderSteven J. KovacsMichael LoobyWileyarticleTherapeutics. PharmacologyRM1-950ENCPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 11, Pp 1276-1280 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Therapeutics. Pharmacology RM1-950
spellingShingle	Therapeutics. Pharmacology RM1-950 Oliver Sander Baldur Magnusson Inga Ludwig Astrid Jullion Christophe Meille Daniel Lorand Björn Bornkamp Markus Hinder Steven J. Kovacs Michael Looby A framework to guide dose & regimen strategy for clinical drug development
description	Abstract Optimizing new drug therapies remains a challenge for clinical development, despite the use of ever more sophisticated quantitative methodologies. Although conceptually simple, the idea of finding the right treatment at the right dose for the right patient to ensure an appropriate balance of risks and benefits is challenging and requires a multidisciplinary approach. In this paper, we present a framework developed as a tool for organizing knowledge and facilitating collaboration in development teams.
format	article
author	Oliver Sander Baldur Magnusson Inga Ludwig Astrid Jullion Christophe Meille Daniel Lorand Björn Bornkamp Markus Hinder Steven J. Kovacs Michael Looby
author_facet	Oliver Sander Baldur Magnusson Inga Ludwig Astrid Jullion Christophe Meille Daniel Lorand Björn Bornkamp Markus Hinder Steven J. Kovacs Michael Looby
author_sort	Oliver Sander
title	A framework to guide dose & regimen strategy for clinical drug development
title_short	A framework to guide dose & regimen strategy for clinical drug development
title_full	A framework to guide dose & regimen strategy for clinical drug development
title_fullStr	A framework to guide dose & regimen strategy for clinical drug development
title_full_unstemmed	A framework to guide dose & regimen strategy for clinical drug development
title_sort	framework to guide dose & regimen strategy for clinical drug development
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/15d1549b9b844cf58ce62297612b8cf4
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A framework to guide dose & regimen strategy for clinical drug development

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