Interleukin-37 regulates innate immune signaling in human and mouse colonic organoids

Interleukin-37 regulates innate immune signaling in human and mouse colonic organoids

Abstract Intestinal epithelial cells (IEC) reside in close proximity to the gut microbiota and are hypo-responsive to bacterial products, likely to prevent maladaptive inflammatory responses. This is in part due to their strong expression of Single Ig IL-1 related receptor (SIGIRR), a negative regul...

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Autores principales: Joannie M. Allaire, Anita Poon, Shauna M. Crowley, Xiao Han, Zohreh Sharafian, Navjit Moore, Martin Stahl, Brian Bressler, Pascal M. Lavoie, Kevan Jacobson, Xiaoxia Li, Bruce A. Vallance
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/15d2427d54394e72ab94d917fb2ea064
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