In vivo evolution of an emerging zoonotic bacterial pathogen in an immunocompromised human host

Bordetella hinzii is an emerging pathogen with zoonotic risk to humans, known to be able to cause respiratory tract infection, bacteremia and endocarditis. Here, applying whole genome sequencing to bacterial isolates, the authors characterize the mechanisms driving adaptive evolution in B. hinzii in...

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Autores principales:	A. Launay, C.-J. Wu, A. Dulanto Chiang, J.-H. Youn, P. P. Khil, J. P. Dekker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/15d257ce9aa446d9b287443d69d5bbb8
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spelling	oai:doaj.org-article:15d257ce9aa446d9b287443d69d5bbb82021-12-02T17:57:16ZIn vivo evolution of an emerging zoonotic bacterial pathogen in an immunocompromised human host10.1038/s41467-021-24668-72041-1723https://doaj.org/article/15d257ce9aa446d9b287443d69d5bbb82021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24668-7https://doaj.org/toc/2041-1723Bordetella hinzii is an emerging pathogen with zoonotic risk to humans, known to be able to cause respiratory tract infection, bacteremia and endocarditis. Here, applying whole genome sequencing to bacterial isolates, the authors characterize the mechanisms driving adaptive evolution in B. hinzii in a patient with interleukin-12 receptor β1 deficiency, suggesting a role for host immune phenotype in shaping within-host pathogen evolution following zoonotic infection.A. LaunayC.-J. WuA. Dulanto ChiangJ.-H. YounP. P. KhilJ. P. DekkerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q A. Launay C.-J. Wu A. Dulanto Chiang J.-H. Youn P. P. Khil J. P. Dekker In vivo evolution of an emerging zoonotic bacterial pathogen in an immunocompromised human host
description	Bordetella hinzii is an emerging pathogen with zoonotic risk to humans, known to be able to cause respiratory tract infection, bacteremia and endocarditis. Here, applying whole genome sequencing to bacterial isolates, the authors characterize the mechanisms driving adaptive evolution in B. hinzii in a patient with interleukin-12 receptor β1 deficiency, suggesting a role for host immune phenotype in shaping within-host pathogen evolution following zoonotic infection.
format	article
author	A. Launay C.-J. Wu A. Dulanto Chiang J.-H. Youn P. P. Khil J. P. Dekker
author_facet	A. Launay C.-J. Wu A. Dulanto Chiang J.-H. Youn P. P. Khil J. P. Dekker
author_sort	A. Launay
title	In vivo evolution of an emerging zoonotic bacterial pathogen in an immunocompromised human host
title_short	In vivo evolution of an emerging zoonotic bacterial pathogen in an immunocompromised human host
title_full	In vivo evolution of an emerging zoonotic bacterial pathogen in an immunocompromised human host
title_fullStr	In vivo evolution of an emerging zoonotic bacterial pathogen in an immunocompromised human host
title_full_unstemmed	In vivo evolution of an emerging zoonotic bacterial pathogen in an immunocompromised human host
title_sort	in vivo evolution of an emerging zoonotic bacterial pathogen in an immunocompromised human host
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/15d257ce9aa446d9b287443d69d5bbb8
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In vivo evolution of an emerging zoonotic bacterial pathogen in an immunocompromised human host

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