CORRELATION OF TRISOMY 12 WITH CLINICAL FEATURES AND OTHER LABORTARY PARAMETERS IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKAEMIA

Objective: To determine the frequency of trisomy 12 in B-Cell chronic lymphocytic leukaemia (CLL), to correlate its association with clinico-pathologic features and to determine the role of this cytogenetic defect to the prognosis. Study Design: Cross sectional study. Place and Duration of Stu...

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Autores principales:	Ali Ahmed, Ch Altaf Hussain, Hamid Saeed Malik, M Abdul Naeem, Rafia Mehmood, Khadija .
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2021
Materias:	chronic lymphocytic leukemia fish trisomy 12 Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/15d87c8eb35b40779a713c232bdcc61f
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spelling	oai:doaj.org-article:15d87c8eb35b40779a713c232bdcc61f2021-12-02T18:44:47ZCORRELATION OF TRISOMY 12 WITH CLINICAL FEATURES AND OTHER LABORTARY PARAMETERS IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKAEMIA0030-96482411-884210.51253/pafmj.v71i2.2679https://doaj.org/article/15d87c8eb35b40779a713c232bdcc61f2021-04-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/2679https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To determine the frequency of trisomy 12 in B-Cell chronic lymphocytic leukaemia (CLL), to correlate its association with clinico-pathologic features and to determine the role of this cytogenetic defect to the prognosis. Study Design: Cross sectional study. Place and Duration of Study: Haematology department, Armed Forces Institute of Pathology, Rawalpindi, from May 2017 to Aug 2018. Methodology: A total of 56 newly diagnosed patients of Chronic Lymphocytic Leukaemia were included in the study. Patients were diagnosed on the basis of National Cancer Institute Working Group guidelines. A detailed history and thorough clinical examination were performed and complete blood counts, biochemical profile, bone marrow examination, immunophenotyping on bone marrow/peripheral blood samples were done for the diagnosis of Chronic lymphocytic leukaemia. Interphase FISH studies were performed on blood/bone marrow aspiration for detection of Trisomy 12 were performed. Results: Out of 56 patients, trisomy was detected in 12 (10.7%) patients. Out of 7 patients with trisomy 12, five patients presented in late stages (Binet stage B and C), however this association of Trisomy 12 with Binet stage was also statistically insignificant (p=0.474). About six with trisomy 12 were positive for CD 38, however this association was also not statistically significant (p=0.124). Results revealed that patients having trisomy 12 underwent chemotherapy at diagnosis and during follow ups as compared to patients having other cytogenic abnormalities. Moreover, patient with trisomy 12 develop progression in disease during course of illness, however association was statistically insignificant (p>0.05)............Ali AhmedCh Altaf HussainHamid Saeed MalikM Abdul NaeemRafia MehmoodKhadija .Army Medical College Rawalpindiarticlechronic lymphocytic leukemiafishtrisomy 12MedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 71, Iss 2, Pp 473-77 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chronic lymphocytic leukemia fish trisomy 12 Medicine R Medicine (General) R5-920
spellingShingle	chronic lymphocytic leukemia fish trisomy 12 Medicine R Medicine (General) R5-920 Ali Ahmed Ch Altaf Hussain Hamid Saeed Malik M Abdul Naeem Rafia Mehmood Khadija . CORRELATION OF TRISOMY 12 WITH CLINICAL FEATURES AND OTHER LABORTARY PARAMETERS IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKAEMIA
description	Objective: To determine the frequency of trisomy 12 in B-Cell chronic lymphocytic leukaemia (CLL), to correlate its association with clinico-pathologic features and to determine the role of this cytogenetic defect to the prognosis. Study Design: Cross sectional study. Place and Duration of Study: Haematology department, Armed Forces Institute of Pathology, Rawalpindi, from May 2017 to Aug 2018. Methodology: A total of 56 newly diagnosed patients of Chronic Lymphocytic Leukaemia were included in the study. Patients were diagnosed on the basis of National Cancer Institute Working Group guidelines. A detailed history and thorough clinical examination were performed and complete blood counts, biochemical profile, bone marrow examination, immunophenotyping on bone marrow/peripheral blood samples were done for the diagnosis of Chronic lymphocytic leukaemia. Interphase FISH studies were performed on blood/bone marrow aspiration for detection of Trisomy 12 were performed. Results: Out of 56 patients, trisomy was detected in 12 (10.7%) patients. Out of 7 patients with trisomy 12, five patients presented in late stages (Binet stage B and C), however this association of Trisomy 12 with Binet stage was also statistically insignificant (p=0.474). About six with trisomy 12 were positive for CD 38, however this association was also not statistically significant (p=0.124). Results revealed that patients having trisomy 12 underwent chemotherapy at diagnosis and during follow ups as compared to patients having other cytogenic abnormalities. Moreover, patient with trisomy 12 develop progression in disease during course of illness, however association was statistically insignificant (p>0.05)............
format	article
author	Ali Ahmed Ch Altaf Hussain Hamid Saeed Malik M Abdul Naeem Rafia Mehmood Khadija .
author_facet	Ali Ahmed Ch Altaf Hussain Hamid Saeed Malik M Abdul Naeem Rafia Mehmood Khadija .
author_sort	Ali Ahmed
title	CORRELATION OF TRISOMY 12 WITH CLINICAL FEATURES AND OTHER LABORTARY PARAMETERS IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKAEMIA
title_short	CORRELATION OF TRISOMY 12 WITH CLINICAL FEATURES AND OTHER LABORTARY PARAMETERS IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKAEMIA
title_full	CORRELATION OF TRISOMY 12 WITH CLINICAL FEATURES AND OTHER LABORTARY PARAMETERS IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKAEMIA
title_fullStr	CORRELATION OF TRISOMY 12 WITH CLINICAL FEATURES AND OTHER LABORTARY PARAMETERS IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKAEMIA
title_full_unstemmed	CORRELATION OF TRISOMY 12 WITH CLINICAL FEATURES AND OTHER LABORTARY PARAMETERS IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKAEMIA
title_sort	correlation of trisomy 12 with clinical features and other labortary parameters in patients with chronic lymphocytic leukaemia
publisher	Army Medical College Rawalpindi
publishDate	2021
url	https://doaj.org/article/15d87c8eb35b40779a713c232bdcc61f
work_keys_str_mv	AT aliahmed correlationoftrisomy12withclinicalfeaturesandotherlabortaryparametersinpatientswithchroniclymphocyticleukaemia AT chaltafhussain correlationoftrisomy12withclinicalfeaturesandotherlabortaryparametersinpatientswithchroniclymphocyticleukaemia AT hamidsaeedmalik correlationoftrisomy12withclinicalfeaturesandotherlabortaryparametersinpatientswithchroniclymphocyticleukaemia AT mabdulnaeem correlationoftrisomy12withclinicalfeaturesandotherlabortaryparametersinpatientswithchroniclymphocyticleukaemia AT rafiamehmood correlationoftrisomy12withclinicalfeaturesandotherlabortaryparametersinpatientswithchroniclymphocyticleukaemia AT khadija correlationoftrisomy12withclinicalfeaturesandotherlabortaryparametersinpatientswithchroniclymphocyticleukaemia
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CORRELATION OF TRISOMY 12 WITH CLINICAL FEATURES AND OTHER LABORTARY PARAMETERS IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKAEMIA

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