Mitochondria-targeted antioxidants as highly effective antibiotics

Abstract Mitochondria-targeted antioxidants are known to alleviate mitochondrial oxidative damage that is associated with a variety of diseases. Here, we showed that SkQ1, a decyltriphenyl phosphonium cation conjugated to a quinone moiety, exhibited strong antibacterial activity towards Gram-positiv...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Pavel A. Nazarov, Ilya A. Osterman, Artem V. Tokarchuk, Marina V. Karakozova, Galina A. Korshunova, Konstantin G. Lyamzaev, Maxim V. Skulachev, Elena A. Kotova, Vladimir P. Skulachev, Yuri N. Antonenko
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/15da0121ba4a44c098f410443074d542
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:15da0121ba4a44c098f410443074d542
record_format	dspace
spelling	oai:doaj.org-article:15da0121ba4a44c098f410443074d5422021-12-02T15:04:55ZMitochondria-targeted antioxidants as highly effective antibiotics10.1038/s41598-017-00802-82045-2322https://doaj.org/article/15da0121ba4a44c098f410443074d5422017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00802-8https://doaj.org/toc/2045-2322Abstract Mitochondria-targeted antioxidants are known to alleviate mitochondrial oxidative damage that is associated with a variety of diseases. Here, we showed that SkQ1, a decyltriphenyl phosphonium cation conjugated to a quinone moiety, exhibited strong antibacterial activity towards Gram-positive Bacillus subtilis, Mycobacterium sp. and Staphylococcus aureus and Gram-negative Photobacterium phosphoreum and Rhodobacter sphaeroides in submicromolar and micromolar concentrations. SkQ1 exhibited less antibiotic activity towards Escherichia coli due to the presence of the highly effective multidrug resistance pump AcrAB-TolC. E. coli mutants lacking AcrAB-TolC showed similar SkQ1 sensitivity, as B. subtilis. Lowering of the bacterial membrane potential by SkQ1 might be involved in the mechanism of its bactericidal action. No significant cytotoxic effect on mammalian cells was observed at bacteriotoxic concentrations of SkQ1. Therefore, SkQ1 may be effective in protection of the infected mammals by killing invading bacteria.Pavel A. NazarovIlya A. OstermanArtem V. TokarchukMarina V. KarakozovaGalina A. KorshunovaKonstantin G. LyamzaevMaxim V. SkulachevElena A. KotovaVladimir P. SkulachevYuri N. AntonenkoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pavel A. Nazarov Ilya A. Osterman Artem V. Tokarchuk Marina V. Karakozova Galina A. Korshunova Konstantin G. Lyamzaev Maxim V. Skulachev Elena A. Kotova Vladimir P. Skulachev Yuri N. Antonenko Mitochondria-targeted antioxidants as highly effective antibiotics
description	Abstract Mitochondria-targeted antioxidants are known to alleviate mitochondrial oxidative damage that is associated with a variety of diseases. Here, we showed that SkQ1, a decyltriphenyl phosphonium cation conjugated to a quinone moiety, exhibited strong antibacterial activity towards Gram-positive Bacillus subtilis, Mycobacterium sp. and Staphylococcus aureus and Gram-negative Photobacterium phosphoreum and Rhodobacter sphaeroides in submicromolar and micromolar concentrations. SkQ1 exhibited less antibiotic activity towards Escherichia coli due to the presence of the highly effective multidrug resistance pump AcrAB-TolC. E. coli mutants lacking AcrAB-TolC showed similar SkQ1 sensitivity, as B. subtilis. Lowering of the bacterial membrane potential by SkQ1 might be involved in the mechanism of its bactericidal action. No significant cytotoxic effect on mammalian cells was observed at bacteriotoxic concentrations of SkQ1. Therefore, SkQ1 may be effective in protection of the infected mammals by killing invading bacteria.
format	article
author	Pavel A. Nazarov Ilya A. Osterman Artem V. Tokarchuk Marina V. Karakozova Galina A. Korshunova Konstantin G. Lyamzaev Maxim V. Skulachev Elena A. Kotova Vladimir P. Skulachev Yuri N. Antonenko
author_facet	Pavel A. Nazarov Ilya A. Osterman Artem V. Tokarchuk Marina V. Karakozova Galina A. Korshunova Konstantin G. Lyamzaev Maxim V. Skulachev Elena A. Kotova Vladimir P. Skulachev Yuri N. Antonenko
author_sort	Pavel A. Nazarov
title	Mitochondria-targeted antioxidants as highly effective antibiotics
title_short	Mitochondria-targeted antioxidants as highly effective antibiotics
title_full	Mitochondria-targeted antioxidants as highly effective antibiotics
title_fullStr	Mitochondria-targeted antioxidants as highly effective antibiotics
title_full_unstemmed	Mitochondria-targeted antioxidants as highly effective antibiotics
title_sort	mitochondria-targeted antioxidants as highly effective antibiotics
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/15da0121ba4a44c098f410443074d542
work_keys_str_mv	AT pavelanazarov mitochondriatargetedantioxidantsashighlyeffectiveantibiotics AT ilyaaosterman mitochondriatargetedantioxidantsashighlyeffectiveantibiotics AT artemvtokarchuk mitochondriatargetedantioxidantsashighlyeffectiveantibiotics AT marinavkarakozova mitochondriatargetedantioxidantsashighlyeffectiveantibiotics AT galinaakorshunova mitochondriatargetedantioxidantsashighlyeffectiveantibiotics AT konstantinglyamzaev mitochondriatargetedantioxidantsashighlyeffectiveantibiotics AT maximvskulachev mitochondriatargetedantioxidantsashighlyeffectiveantibiotics AT elenaakotova mitochondriatargetedantioxidantsashighlyeffectiveantibiotics AT vladimirpskulachev mitochondriatargetedantioxidantsashighlyeffectiveantibiotics AT yurinantonenko mitochondriatargetedantioxidantsashighlyeffectiveantibiotics
_version_	1718389000517976064

Mitochondria-targeted antioxidants as highly effective antibiotics

Ejemplares similares