Wdr1 and cofilin are necessary mediators of immune-cell-specific apoptosis triggered by Tecfidera

The mechanism-of-action of many electrohilic drugs remains poorly understood. Here, the authors use a redox-targeting approach to elucidate the basis for the innate immune cell toxicity of dimethyl fumarate, showing that it modifies Keap1 to trigger mitochondrial-targeted neutrophil/macrophage apopt...

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Autores principales:	Jesse R. Poganik, Kuan-Ting Huang, Saba Parvez, Yi Zhao, Sruthi Raja, Marcus J. C. Long, Yimon Aye
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/15dd3ed4393e41a09aeb7a84a8f77b17
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spelling	oai:doaj.org-article:15dd3ed4393e41a09aeb7a84a8f77b172021-12-02T17:37:36ZWdr1 and cofilin are necessary mediators of immune-cell-specific apoptosis triggered by Tecfidera10.1038/s41467-021-25466-x2041-1723https://doaj.org/article/15dd3ed4393e41a09aeb7a84a8f77b172021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25466-xhttps://doaj.org/toc/2041-1723The mechanism-of-action of many electrohilic drugs remains poorly understood. Here, the authors use a redox-targeting approach to elucidate the basis for the innate immune cell toxicity of dimethyl fumarate, showing that it modifies Keap1 to trigger mitochondrial-targeted neutrophil/macrophage apoptosis.Jesse R. PoganikKuan-Ting HuangSaba ParvezYi ZhaoSruthi RajaMarcus J. C. LongYimon AyeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jesse R. Poganik Kuan-Ting Huang Saba Parvez Yi Zhao Sruthi Raja Marcus J. C. Long Yimon Aye Wdr1 and cofilin are necessary mediators of immune-cell-specific apoptosis triggered by Tecfidera
description	The mechanism-of-action of many electrohilic drugs remains poorly understood. Here, the authors use a redox-targeting approach to elucidate the basis for the innate immune cell toxicity of dimethyl fumarate, showing that it modifies Keap1 to trigger mitochondrial-targeted neutrophil/macrophage apoptosis.
format	article
author	Jesse R. Poganik Kuan-Ting Huang Saba Parvez Yi Zhao Sruthi Raja Marcus J. C. Long Yimon Aye
author_facet	Jesse R. Poganik Kuan-Ting Huang Saba Parvez Yi Zhao Sruthi Raja Marcus J. C. Long Yimon Aye
author_sort	Jesse R. Poganik
title	Wdr1 and cofilin are necessary mediators of immune-cell-specific apoptosis triggered by Tecfidera
title_short	Wdr1 and cofilin are necessary mediators of immune-cell-specific apoptosis triggered by Tecfidera
title_full	Wdr1 and cofilin are necessary mediators of immune-cell-specific apoptosis triggered by Tecfidera
title_fullStr	Wdr1 and cofilin are necessary mediators of immune-cell-specific apoptosis triggered by Tecfidera
title_full_unstemmed	Wdr1 and cofilin are necessary mediators of immune-cell-specific apoptosis triggered by Tecfidera
title_sort	wdr1 and cofilin are necessary mediators of immune-cell-specific apoptosis triggered by tecfidera
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/15dd3ed4393e41a09aeb7a84a8f77b17
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Wdr1 and cofilin are necessary mediators of immune-cell-specific apoptosis triggered by Tecfidera

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