Accelerated disease progression and robust innate host response in aged SIVmac239-infected Chinese rhesus macaques is associated with enhanced immunosenescence

Abstract The elderly population infected with HIV-1 is often characterized by the rapid AIDS progression and poor treatment outcome, possibly because of immunosenescence resulting from both HIV infection and aging. However, this hypothesis remains to be fully tested. Here, we studied 6 young and 12...

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Autores principales:	Hong-Yi Zheng, Ming-Xu Zhang, Min Chen, Jin Jiang, Jia-Hao Song, Xiao-Dong Lian, Ren-Rong Tian, Xiao-Liang Zhang, Lin-Tao Zhang, Wei Pang, Gao-Hong Zhang, Yong-Tang Zheng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/15de5e1f859f40b287d4b3ff06d103af
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spelling	oai:doaj.org-article:15de5e1f859f40b287d4b3ff06d103af2021-12-02T11:53:11ZAccelerated disease progression and robust innate host response in aged SIVmac239-infected Chinese rhesus macaques is associated with enhanced immunosenescence10.1038/s41598-017-00084-02045-2322https://doaj.org/article/15de5e1f859f40b287d4b3ff06d103af2017-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00084-0https://doaj.org/toc/2045-2322Abstract The elderly population infected with HIV-1 is often characterized by the rapid AIDS progression and poor treatment outcome, possibly because of immunosenescence resulting from both HIV infection and aging. However, this hypothesis remains to be fully tested. Here, we studied 6 young and 12 old Chinese rhesus macaques (ChRM) over the course of three months after simian immunodeficiency virus (SIV) SIVmac239 infection. Old ChRM showed a higher risk of accelerated AIDS development than did young macaques, owing to rapidly elevated plasma viral loads and decreased levels of CD4+ T cells. The low frequency of naïve CD4+ T cells before infection was strongly predictive of an increased disease progression, whereas the severe depletion of CD4+ T cells and the rapid proliferation of naïve lymphocytes accelerated the exhaustion of naïve lymphocytes in old ChRM. Moreover, in old ChRM, a robust innate host response with defective regulation was associated with a compensation for naïve T cell depletion and a high level of immune activation. Therefore, we suggest that immunosenescence plays an important role in the accelerated AIDS progression in elderly individuals and that SIV-infected old ChRM may be a favorable model for studying AIDS pathogenesis and researching therapies for elderly AIDS patients.Hong-Yi ZhengMing-Xu ZhangMin ChenJin JiangJia-Hao SongXiao-Dong LianRen-Rong TianXiao-Liang ZhangLin-Tao ZhangWei PangGao-Hong ZhangYong-Tang ZhengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hong-Yi Zheng Ming-Xu Zhang Min Chen Jin Jiang Jia-Hao Song Xiao-Dong Lian Ren-Rong Tian Xiao-Liang Zhang Lin-Tao Zhang Wei Pang Gao-Hong Zhang Yong-Tang Zheng Accelerated disease progression and robust innate host response in aged SIVmac239-infected Chinese rhesus macaques is associated with enhanced immunosenescence
description	Abstract The elderly population infected with HIV-1 is often characterized by the rapid AIDS progression and poor treatment outcome, possibly because of immunosenescence resulting from both HIV infection and aging. However, this hypothesis remains to be fully tested. Here, we studied 6 young and 12 old Chinese rhesus macaques (ChRM) over the course of three months after simian immunodeficiency virus (SIV) SIVmac239 infection. Old ChRM showed a higher risk of accelerated AIDS development than did young macaques, owing to rapidly elevated plasma viral loads and decreased levels of CD4+ T cells. The low frequency of naïve CD4+ T cells before infection was strongly predictive of an increased disease progression, whereas the severe depletion of CD4+ T cells and the rapid proliferation of naïve lymphocytes accelerated the exhaustion of naïve lymphocytes in old ChRM. Moreover, in old ChRM, a robust innate host response with defective regulation was associated with a compensation for naïve T cell depletion and a high level of immune activation. Therefore, we suggest that immunosenescence plays an important role in the accelerated AIDS progression in elderly individuals and that SIV-infected old ChRM may be a favorable model for studying AIDS pathogenesis and researching therapies for elderly AIDS patients.
format	article
author	Hong-Yi Zheng Ming-Xu Zhang Min Chen Jin Jiang Jia-Hao Song Xiao-Dong Lian Ren-Rong Tian Xiao-Liang Zhang Lin-Tao Zhang Wei Pang Gao-Hong Zhang Yong-Tang Zheng
author_facet	Hong-Yi Zheng Ming-Xu Zhang Min Chen Jin Jiang Jia-Hao Song Xiao-Dong Lian Ren-Rong Tian Xiao-Liang Zhang Lin-Tao Zhang Wei Pang Gao-Hong Zhang Yong-Tang Zheng
author_sort	Hong-Yi Zheng
title	Accelerated disease progression and robust innate host response in aged SIVmac239-infected Chinese rhesus macaques is associated with enhanced immunosenescence
title_short	Accelerated disease progression and robust innate host response in aged SIVmac239-infected Chinese rhesus macaques is associated with enhanced immunosenescence
title_full	Accelerated disease progression and robust innate host response in aged SIVmac239-infected Chinese rhesus macaques is associated with enhanced immunosenescence
title_fullStr	Accelerated disease progression and robust innate host response in aged SIVmac239-infected Chinese rhesus macaques is associated with enhanced immunosenescence
title_full_unstemmed	Accelerated disease progression and robust innate host response in aged SIVmac239-infected Chinese rhesus macaques is associated with enhanced immunosenescence
title_sort	accelerated disease progression and robust innate host response in aged sivmac239-infected chinese rhesus macaques is associated with enhanced immunosenescence
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/15de5e1f859f40b287d4b3ff06d103af
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Accelerated disease progression and robust innate host response in aged SIVmac239-infected Chinese rhesus macaques is associated with enhanced immunosenescence

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