Developmental Whole Brain White Matter Alterations in Transgenic Huntington’s Disease Monkey

Abstract Transgenic Huntington’s disease monkey (HD monkey) model provides great opportunity for studying disease progression that could lead to new insight for developing biomarker, early intervention and novel therapeutics. Whole brain white matter integrity of HD-monkeys was examined longitudinal...

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Autores principales:	Yuguang Meng, Jie Jiang, Jocelyne Bachevalier, Xiaodong Zhang, Anthony W. S. Chan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/15df315e441946e5b43e51312843cfa0
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spelling	oai:doaj.org-article:15df315e441946e5b43e51312843cfa02021-12-02T15:05:23ZDevelopmental Whole Brain White Matter Alterations in Transgenic Huntington’s Disease Monkey10.1038/s41598-017-00381-82045-2322https://doaj.org/article/15df315e441946e5b43e51312843cfa02017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00381-8https://doaj.org/toc/2045-2322Abstract Transgenic Huntington’s disease monkey (HD monkey) model provides great opportunity for studying disease progression that could lead to new insight for developing biomarker, early intervention and novel therapeutics. Whole brain white matter integrity of HD-monkeys was examined longitudinally from 6 to 48 months using diffusion tensor imaging (DTI) and tract-based spatial statistics (TBSS). Progressive developmental white matter alterations in HD monkeys were widespread and were observed not only in fiber bundles connecting cortical areas to the striatum (e.g. striatal bundle and external capsule), but also in long association fiber pathways, commissural fibers, and subcortical fiber bundle. In all fiber tracts, the data indicate an arrest in white matter development around 23 months followed by slight decline until adulthood in HD monkeys. The microstructural changes parallel the progressive motor, memory and cognitive decline previously reported as HD monkeys aged. The findings revealed the widespread progressive temporal-spatial microstructural changes in HD monkey brains from infancy to adulthood, suggesting differentiated degenerations across different brain areas during brain development.Yuguang MengJie JiangJocelyne BachevalierXiaodong ZhangAnthony W. S. ChanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuguang Meng Jie Jiang Jocelyne Bachevalier Xiaodong Zhang Anthony W. S. Chan Developmental Whole Brain White Matter Alterations in Transgenic Huntington’s Disease Monkey
description	Abstract Transgenic Huntington’s disease monkey (HD monkey) model provides great opportunity for studying disease progression that could lead to new insight for developing biomarker, early intervention and novel therapeutics. Whole brain white matter integrity of HD-monkeys was examined longitudinally from 6 to 48 months using diffusion tensor imaging (DTI) and tract-based spatial statistics (TBSS). Progressive developmental white matter alterations in HD monkeys were widespread and were observed not only in fiber bundles connecting cortical areas to the striatum (e.g. striatal bundle and external capsule), but also in long association fiber pathways, commissural fibers, and subcortical fiber bundle. In all fiber tracts, the data indicate an arrest in white matter development around 23 months followed by slight decline until adulthood in HD monkeys. The microstructural changes parallel the progressive motor, memory and cognitive decline previously reported as HD monkeys aged. The findings revealed the widespread progressive temporal-spatial microstructural changes in HD monkey brains from infancy to adulthood, suggesting differentiated degenerations across different brain areas during brain development.
format	article
author	Yuguang Meng Jie Jiang Jocelyne Bachevalier Xiaodong Zhang Anthony W. S. Chan
author_facet	Yuguang Meng Jie Jiang Jocelyne Bachevalier Xiaodong Zhang Anthony W. S. Chan
author_sort	Yuguang Meng
title	Developmental Whole Brain White Matter Alterations in Transgenic Huntington’s Disease Monkey
title_short	Developmental Whole Brain White Matter Alterations in Transgenic Huntington’s Disease Monkey
title_full	Developmental Whole Brain White Matter Alterations in Transgenic Huntington’s Disease Monkey
title_fullStr	Developmental Whole Brain White Matter Alterations in Transgenic Huntington’s Disease Monkey
title_full_unstemmed	Developmental Whole Brain White Matter Alterations in Transgenic Huntington’s Disease Monkey
title_sort	developmental whole brain white matter alterations in transgenic huntington’s disease monkey
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/15df315e441946e5b43e51312843cfa0
work_keys_str_mv	AT yuguangmeng developmentalwholebrainwhitematteralterationsintransgenichuntingtonsdiseasemonkey AT jiejiang developmentalwholebrainwhitematteralterationsintransgenichuntingtonsdiseasemonkey AT jocelynebachevalier developmentalwholebrainwhitematteralterationsintransgenichuntingtonsdiseasemonkey AT xiaodongzhang developmentalwholebrainwhitematteralterationsintransgenichuntingtonsdiseasemonkey AT anthonywschan developmentalwholebrainwhitematteralterationsintransgenichuntingtonsdiseasemonkey
_version_	1718388815075213312

Developmental Whole Brain White Matter Alterations in Transgenic Huntington’s Disease Monkey

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