Majority of Chinese Medicine Herb Category “Qing Re Yao” Have Multiple Mechanisms of Anti-inflammatory Activity

Abstract Herbs categorized as “Qing Re Yao” are translated into “medicine that removes heat” where heat symptoms strongly resemble inflammation. 226 herbs, among those 54 herbs are classified as “Qing Re Yao”, were studied on six key mechanisms of inflammation: COX2, iNOS activity, and the pathways...

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Autores principales:	Fulan Guan, Wing Lam, Rong Hu, Yun Kyung Kim, Hua Han, Yung-Chi Cheng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/15e00de2123444fa96c2219271c87e05
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spelling	oai:doaj.org-article:15e00de2123444fa96c2219271c87e052021-12-02T11:41:25ZMajority of Chinese Medicine Herb Category “Qing Re Yao” Have Multiple Mechanisms of Anti-inflammatory Activity10.1038/s41598-018-25813-x2045-2322https://doaj.org/article/15e00de2123444fa96c2219271c87e052018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25813-xhttps://doaj.org/toc/2045-2322Abstract Herbs categorized as “Qing Re Yao” are translated into “medicine that removes heat” where heat symptoms strongly resemble inflammation. 226 herbs, among those 54 herbs are classified as “Qing Re Yao”, were studied on six key mechanisms of inflammation: COX2, iNOS activity, and the pathways of IL-6, IFNγ, TNF-α and glucocorticoid in order to assess if the majority of this family of herbs have anti-inflammatory activity. 96% demonstrated at least one anti-inflammatory process or innate immunity modular activity, and 72% could affect one anti-inflammatory process. Of the, 54 “Qing Re Yao” 68% affect at least 2 mechanism compared to only 4% (47 herbs) in the “Bu Yi Yao” category that are used to “tonify body energy” and prevent diseases. Moreover 43% of “Qing Re Yao” herbs affect 3 or more mechanisms while none of the “Bu Yi Yao” have this poly-mechanism quality. Additionally “Qing Re Yao” herbs exhibiting activity against STAT3 or GAS could have downstream effects on these target genes and their pathways. Our study addresses the key action on why “Qing Re Yao” work on inflammation. This study also demonstrates the utility in isolating anti-inflammatory substances to be used as a lead for drug discovery and development.Fulan GuanWing LamRong HuYun Kyung KimHua HanYung-Chi ChengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fulan Guan Wing Lam Rong Hu Yun Kyung Kim Hua Han Yung-Chi Cheng Majority of Chinese Medicine Herb Category “Qing Re Yao” Have Multiple Mechanisms of Anti-inflammatory Activity
description	Abstract Herbs categorized as “Qing Re Yao” are translated into “medicine that removes heat” where heat symptoms strongly resemble inflammation. 226 herbs, among those 54 herbs are classified as “Qing Re Yao”, were studied on six key mechanisms of inflammation: COX2, iNOS activity, and the pathways of IL-6, IFNγ, TNF-α and glucocorticoid in order to assess if the majority of this family of herbs have anti-inflammatory activity. 96% demonstrated at least one anti-inflammatory process or innate immunity modular activity, and 72% could affect one anti-inflammatory process. Of the, 54 “Qing Re Yao” 68% affect at least 2 mechanism compared to only 4% (47 herbs) in the “Bu Yi Yao” category that are used to “tonify body energy” and prevent diseases. Moreover 43% of “Qing Re Yao” herbs affect 3 or more mechanisms while none of the “Bu Yi Yao” have this poly-mechanism quality. Additionally “Qing Re Yao” herbs exhibiting activity against STAT3 or GAS could have downstream effects on these target genes and their pathways. Our study addresses the key action on why “Qing Re Yao” work on inflammation. This study also demonstrates the utility in isolating anti-inflammatory substances to be used as a lead for drug discovery and development.
format	article
author	Fulan Guan Wing Lam Rong Hu Yun Kyung Kim Hua Han Yung-Chi Cheng
author_facet	Fulan Guan Wing Lam Rong Hu Yun Kyung Kim Hua Han Yung-Chi Cheng
author_sort	Fulan Guan
title	Majority of Chinese Medicine Herb Category “Qing Re Yao” Have Multiple Mechanisms of Anti-inflammatory Activity
title_short	Majority of Chinese Medicine Herb Category “Qing Re Yao” Have Multiple Mechanisms of Anti-inflammatory Activity
title_full	Majority of Chinese Medicine Herb Category “Qing Re Yao” Have Multiple Mechanisms of Anti-inflammatory Activity
title_fullStr	Majority of Chinese Medicine Herb Category “Qing Re Yao” Have Multiple Mechanisms of Anti-inflammatory Activity
title_full_unstemmed	Majority of Chinese Medicine Herb Category “Qing Re Yao” Have Multiple Mechanisms of Anti-inflammatory Activity
title_sort	majority of chinese medicine herb category “qing re yao” have multiple mechanisms of anti-inflammatory activity
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/15e00de2123444fa96c2219271c87e05
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Majority of Chinese Medicine Herb Category “Qing Re Yao” Have Multiple Mechanisms of Anti-inflammatory Activity

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