Numerical and experimental analysis of a hybrid material acoustophoretic device for manipulation of microparticles

Abstract Acoustophoretic microfluidic devices have been developed for accurate, label-free, contactless, and non-invasive manipulation of bioparticles in different biofluids. However, their widespread application is limited due to the need for the use of high quality microchannels made of materials...

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Autores principales:	Alireza Barani, Peiman Mosaddegh, Shaghayegh Haghjooy Javanmard, Shahrokh Sepehrirahnama, Amir Sanati-Nezhad
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/15e16ced6c4d4fe8bda22f46c40d9d19
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spelling	oai:doaj.org-article:15e16ced6c4d4fe8bda22f46c40d9d192021-11-14T12:22:32ZNumerical and experimental analysis of a hybrid material acoustophoretic device for manipulation of microparticles10.1038/s41598-021-01459-02045-2322https://doaj.org/article/15e16ced6c4d4fe8bda22f46c40d9d192021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01459-0https://doaj.org/toc/2045-2322Abstract Acoustophoretic microfluidic devices have been developed for accurate, label-free, contactless, and non-invasive manipulation of bioparticles in different biofluids. However, their widespread application is limited due to the need for the use of high quality microchannels made of materials with high specific acoustic impedances relative to the fluid (e.g., silicon or glass with small damping coefficient), manufactured by complex and expensive microfabrication processes. Soft polymers with a lower fabrication cost have been introduced to address the challenges of silicon- or glass-based acoustophoretic microfluidic systems. However, due to their small acoustic impedance, their efficacy for particle manipulation is shown to be limited. Here, we developed a new acoustophoretic microfluid system fabricated by a hybrid sound-hard (aluminum) and sound-soft (polydimethylsiloxane polymer) material. The performance of this hybrid device for manipulation of bead particles and cells was compared to the acoustophoretic devices made of acoustically hard materials. The results show that particles and cells in the hybrid material microchannel travel to a nodal plane with a much smaller energy density than conventional acoustic-hard devices but greater than polymeric microfluidic chips. Against conventional acoustic-hard chips, the nodal line in the hybrid microchannel could be easily tuned to be placed in an off-center position by changing the frequency, effective for particle separation from a host fluid in parallel flow stream models. It is also shown that the hybrid acoustophoretic device deals with smaller temperature rise which is safer for the actuation of bioparticles. This new device eliminates the limitations of each sound-soft and sound-hard materials in terms of cost, adjusting the position of nodal plane, temperature rise, fragility, production cost and disposability, making it desirable for developing the next generation of economically viable acoustophoretic products for ultrasound particle manipulation in bioengineering applications.Alireza BaraniPeiman MosaddeghShaghayegh Haghjooy JavanmardShahrokh SepehrirahnamaAmir Sanati-NezhadNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alireza Barani Peiman Mosaddegh Shaghayegh Haghjooy Javanmard Shahrokh Sepehrirahnama Amir Sanati-Nezhad Numerical and experimental analysis of a hybrid material acoustophoretic device for manipulation of microparticles
description	Abstract Acoustophoretic microfluidic devices have been developed for accurate, label-free, contactless, and non-invasive manipulation of bioparticles in different biofluids. However, their widespread application is limited due to the need for the use of high quality microchannels made of materials with high specific acoustic impedances relative to the fluid (e.g., silicon or glass with small damping coefficient), manufactured by complex and expensive microfabrication processes. Soft polymers with a lower fabrication cost have been introduced to address the challenges of silicon- or glass-based acoustophoretic microfluidic systems. However, due to their small acoustic impedance, their efficacy for particle manipulation is shown to be limited. Here, we developed a new acoustophoretic microfluid system fabricated by a hybrid sound-hard (aluminum) and sound-soft (polydimethylsiloxane polymer) material. The performance of this hybrid device for manipulation of bead particles and cells was compared to the acoustophoretic devices made of acoustically hard materials. The results show that particles and cells in the hybrid material microchannel travel to a nodal plane with a much smaller energy density than conventional acoustic-hard devices but greater than polymeric microfluidic chips. Against conventional acoustic-hard chips, the nodal line in the hybrid microchannel could be easily tuned to be placed in an off-center position by changing the frequency, effective for particle separation from a host fluid in parallel flow stream models. It is also shown that the hybrid acoustophoretic device deals with smaller temperature rise which is safer for the actuation of bioparticles. This new device eliminates the limitations of each sound-soft and sound-hard materials in terms of cost, adjusting the position of nodal plane, temperature rise, fragility, production cost and disposability, making it desirable for developing the next generation of economically viable acoustophoretic products for ultrasound particle manipulation in bioengineering applications.
format	article
author	Alireza Barani Peiman Mosaddegh Shaghayegh Haghjooy Javanmard Shahrokh Sepehrirahnama Amir Sanati-Nezhad
author_facet	Alireza Barani Peiman Mosaddegh Shaghayegh Haghjooy Javanmard Shahrokh Sepehrirahnama Amir Sanati-Nezhad
author_sort	Alireza Barani
title	Numerical and experimental analysis of a hybrid material acoustophoretic device for manipulation of microparticles
title_short	Numerical and experimental analysis of a hybrid material acoustophoretic device for manipulation of microparticles
title_full	Numerical and experimental analysis of a hybrid material acoustophoretic device for manipulation of microparticles
title_fullStr	Numerical and experimental analysis of a hybrid material acoustophoretic device for manipulation of microparticles
title_full_unstemmed	Numerical and experimental analysis of a hybrid material acoustophoretic device for manipulation of microparticles
title_sort	numerical and experimental analysis of a hybrid material acoustophoretic device for manipulation of microparticles
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/15e16ced6c4d4fe8bda22f46c40d9d19
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_version_	1718429213564862464

Numerical and experimental analysis of a hybrid material acoustophoretic device for manipulation of microparticles

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