Diagnostic accuracy of interferon-gamma-induced protein 10 for differentiating active tuberculosis from latent tuberculosis: A meta-analysis

Abstract Tuberculin skin test and interferon-gamma release assay are not good at differentiating active tuberculosis from latent tuberculosis. Interferon-gamma-induced protein 10 (IP-10) has been widely used to detect tuberculosis infection. However, its values of discriminating active and latent tu...

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Autores principales:	Xia Qiu, Ying Tang, Rong Zou, Yan Zeng, Yan Yue, Wenxing Li, Yi Qu, Dezhi Mu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/15e392ca9d68446da104339d4c7dcca3
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spelling	oai:doaj.org-article:15e392ca9d68446da104339d4c7dcca32021-12-02T15:08:59ZDiagnostic accuracy of interferon-gamma-induced protein 10 for differentiating active tuberculosis from latent tuberculosis: A meta-analysis10.1038/s41598-019-47923-w2045-2322https://doaj.org/article/15e392ca9d68446da104339d4c7dcca32019-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-47923-whttps://doaj.org/toc/2045-2322Abstract Tuberculin skin test and interferon-gamma release assay are not good at differentiating active tuberculosis from latent tuberculosis. Interferon-gamma-induced protein 10 (IP-10) has been widely used to detect tuberculosis infection. However, its values of discriminating active and latent tuberculosis is unknown. To estimate the diagnostic potential of IP-10 for differentiating active tuberculosis from latent tuberculosis, we searched PubMed, Web of Science, Embase, the Cochrane Library, CNKI, Wanfang, VIP and CBM databases. Eleven studies, accounting for 706 participants (853 samples), were included. We used a bivariate diagnostic random-effects model to conduct the primary data. The overall pooled sensitivity, specificity, negative likelihood rate, positive likelihood rate, diagnostic odds ratio and area under the summary receiver operating characteristic curve were 0.72 (95% CI: 0.68–0.76), 0.83 (95% CI: 0.79–0.87), 0.32 (95% CI: 0.22–0.46), 4.63 (95% CI: 2.79–7.69), 17.86 (95% CI: 2.89–38.49) and 0.8638, respectively. This study shows that IP-10 is a potential biomarker for differentiating active tuberculosis from latent tuberculosis.Xia QiuYing TangRong ZouYan ZengYan YueWenxing LiYi QuDezhi MuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xia Qiu Ying Tang Rong Zou Yan Zeng Yan Yue Wenxing Li Yi Qu Dezhi Mu Diagnostic accuracy of interferon-gamma-induced protein 10 for differentiating active tuberculosis from latent tuberculosis: A meta-analysis
description	Abstract Tuberculin skin test and interferon-gamma release assay are not good at differentiating active tuberculosis from latent tuberculosis. Interferon-gamma-induced protein 10 (IP-10) has been widely used to detect tuberculosis infection. However, its values of discriminating active and latent tuberculosis is unknown. To estimate the diagnostic potential of IP-10 for differentiating active tuberculosis from latent tuberculosis, we searched PubMed, Web of Science, Embase, the Cochrane Library, CNKI, Wanfang, VIP and CBM databases. Eleven studies, accounting for 706 participants (853 samples), were included. We used a bivariate diagnostic random-effects model to conduct the primary data. The overall pooled sensitivity, specificity, negative likelihood rate, positive likelihood rate, diagnostic odds ratio and area under the summary receiver operating characteristic curve were 0.72 (95% CI: 0.68–0.76), 0.83 (95% CI: 0.79–0.87), 0.32 (95% CI: 0.22–0.46), 4.63 (95% CI: 2.79–7.69), 17.86 (95% CI: 2.89–38.49) and 0.8638, respectively. This study shows that IP-10 is a potential biomarker for differentiating active tuberculosis from latent tuberculosis.
format	article
author	Xia Qiu Ying Tang Rong Zou Yan Zeng Yan Yue Wenxing Li Yi Qu Dezhi Mu
author_facet	Xia Qiu Ying Tang Rong Zou Yan Zeng Yan Yue Wenxing Li Yi Qu Dezhi Mu
author_sort	Xia Qiu
title	Diagnostic accuracy of interferon-gamma-induced protein 10 for differentiating active tuberculosis from latent tuberculosis: A meta-analysis
title_short	Diagnostic accuracy of interferon-gamma-induced protein 10 for differentiating active tuberculosis from latent tuberculosis: A meta-analysis
title_full	Diagnostic accuracy of interferon-gamma-induced protein 10 for differentiating active tuberculosis from latent tuberculosis: A meta-analysis
title_fullStr	Diagnostic accuracy of interferon-gamma-induced protein 10 for differentiating active tuberculosis from latent tuberculosis: A meta-analysis
title_full_unstemmed	Diagnostic accuracy of interferon-gamma-induced protein 10 for differentiating active tuberculosis from latent tuberculosis: A meta-analysis
title_sort	diagnostic accuracy of interferon-gamma-induced protein 10 for differentiating active tuberculosis from latent tuberculosis: a meta-analysis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/15e392ca9d68446da104339d4c7dcca3
work_keys_str_mv	AT xiaqiu diagnosticaccuracyofinterferongammainducedprotein10fordifferentiatingactivetuberculosisfromlatenttuberculosisametaanalysis AT yingtang diagnosticaccuracyofinterferongammainducedprotein10fordifferentiatingactivetuberculosisfromlatenttuberculosisametaanalysis AT rongzou diagnosticaccuracyofinterferongammainducedprotein10fordifferentiatingactivetuberculosisfromlatenttuberculosisametaanalysis AT yanzeng diagnosticaccuracyofinterferongammainducedprotein10fordifferentiatingactivetuberculosisfromlatenttuberculosisametaanalysis AT yanyue diagnosticaccuracyofinterferongammainducedprotein10fordifferentiatingactivetuberculosisfromlatenttuberculosisametaanalysis AT wenxingli diagnosticaccuracyofinterferongammainducedprotein10fordifferentiatingactivetuberculosisfromlatenttuberculosisametaanalysis AT yiqu diagnosticaccuracyofinterferongammainducedprotein10fordifferentiatingactivetuberculosisfromlatenttuberculosisametaanalysis AT dezhimu diagnosticaccuracyofinterferongammainducedprotein10fordifferentiatingactivetuberculosisfromlatenttuberculosisametaanalysis
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Diagnostic accuracy of interferon-gamma-induced protein 10 for differentiating active tuberculosis from latent tuberculosis: A meta-analysis

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