First description of a widespread Mytilus trossulus-derived bivalve transmissible cancer lineage in M. trossulus itself

Abstract Two lineages of bivalve transmissible neoplasia (BTN), BTN1 and BTN2, are known in blue mussels Mytilus. Both lineages derive from the Pacific mussel M. trossulus and are identified primarily by their unique genotypes of the nuclear gene EF1α. BTN1 is found in populations of M. trossulus fr...

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Autores principales:	Maria Skazina, Nelly Odintsova, Maria Maiorova, Angelina Ivanova, Risto Väinölä, Petr Strelkov
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/15e4158e6cb34184b3f8c868cbc2383d
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spelling	oai:doaj.org-article:15e4158e6cb34184b3f8c868cbc2383d2021-12-02T13:19:23ZFirst description of a widespread Mytilus trossulus-derived bivalve transmissible cancer lineage in M. trossulus itself10.1038/s41598-021-85098-52045-2322https://doaj.org/article/15e4158e6cb34184b3f8c868cbc2383d2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85098-5https://doaj.org/toc/2045-2322Abstract Two lineages of bivalve transmissible neoplasia (BTN), BTN1 and BTN2, are known in blue mussels Mytilus. Both lineages derive from the Pacific mussel M. trossulus and are identified primarily by their unique genotypes of the nuclear gene EF1α. BTN1 is found in populations of M. trossulus from the Northeast Pacific, while BTN2 has been detected in populations of other Mytilus species worldwide but not in M. trossulus itself. Here we examined M. trossulus from the Sea of Japan (Northwest Pacific) for the presence of BTN. Using hemocytology and flow cytometry of the hemolymph, we confirmed the presence of disseminated neoplasia in our specimens. Cancerous mussels possessed the BTN2 EF1α genotype and two mitochondrial haplotypes with different recombinant control regions, similar to that of common BTN2 lineages. This is the first report of BTN2 in its original host species M. trossulus. A comparison of all available BTN and M. trossulus COI sequences suggests a common and recent origin of BTN2 diversity in populations of M. trossulus outside the Northeast Pacific, possibly in the Northwest Pacific.Maria SkazinaNelly OdintsovaMaria MaiorovaAngelina IvanovaRisto VäinöläPetr StrelkovNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maria Skazina Nelly Odintsova Maria Maiorova Angelina Ivanova Risto Väinölä Petr Strelkov First description of a widespread Mytilus trossulus-derived bivalve transmissible cancer lineage in M. trossulus itself
description	Abstract Two lineages of bivalve transmissible neoplasia (BTN), BTN1 and BTN2, are known in blue mussels Mytilus. Both lineages derive from the Pacific mussel M. trossulus and are identified primarily by their unique genotypes of the nuclear gene EF1α. BTN1 is found in populations of M. trossulus from the Northeast Pacific, while BTN2 has been detected in populations of other Mytilus species worldwide but not in M. trossulus itself. Here we examined M. trossulus from the Sea of Japan (Northwest Pacific) for the presence of BTN. Using hemocytology and flow cytometry of the hemolymph, we confirmed the presence of disseminated neoplasia in our specimens. Cancerous mussels possessed the BTN2 EF1α genotype and two mitochondrial haplotypes with different recombinant control regions, similar to that of common BTN2 lineages. This is the first report of BTN2 in its original host species M. trossulus. A comparison of all available BTN and M. trossulus COI sequences suggests a common and recent origin of BTN2 diversity in populations of M. trossulus outside the Northeast Pacific, possibly in the Northwest Pacific.
format	article
author	Maria Skazina Nelly Odintsova Maria Maiorova Angelina Ivanova Risto Väinölä Petr Strelkov
author_facet	Maria Skazina Nelly Odintsova Maria Maiorova Angelina Ivanova Risto Väinölä Petr Strelkov
author_sort	Maria Skazina
title	First description of a widespread Mytilus trossulus-derived bivalve transmissible cancer lineage in M. trossulus itself
title_short	First description of a widespread Mytilus trossulus-derived bivalve transmissible cancer lineage in M. trossulus itself
title_full	First description of a widespread Mytilus trossulus-derived bivalve transmissible cancer lineage in M. trossulus itself
title_fullStr	First description of a widespread Mytilus trossulus-derived bivalve transmissible cancer lineage in M. trossulus itself
title_full_unstemmed	First description of a widespread Mytilus trossulus-derived bivalve transmissible cancer lineage in M. trossulus itself
title_sort	first description of a widespread mytilus trossulus-derived bivalve transmissible cancer lineage in m. trossulus itself
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/15e4158e6cb34184b3f8c868cbc2383d
work_keys_str_mv	AT mariaskazina firstdescriptionofawidespreadmytilustrossulusderivedbivalvetransmissiblecancerlineageinmtrossulusitself AT nellyodintsova firstdescriptionofawidespreadmytilustrossulusderivedbivalvetransmissiblecancerlineageinmtrossulusitself AT mariamaiorova firstdescriptionofawidespreadmytilustrossulusderivedbivalvetransmissiblecancerlineageinmtrossulusitself AT angelinaivanova firstdescriptionofawidespreadmytilustrossulusderivedbivalvetransmissiblecancerlineageinmtrossulusitself AT ristovainola firstdescriptionofawidespreadmytilustrossulusderivedbivalvetransmissiblecancerlineageinmtrossulusitself AT petrstrelkov firstdescriptionofawidespreadmytilustrossulusderivedbivalvetransmissiblecancerlineageinmtrossulusitself
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First description of a widespread Mytilus trossulus-derived bivalve transmissible cancer lineage in M. trossulus itself

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