Role of endothelial cell specific molecule-1 (endocan) and cardiac imaging in early detection of cardiac involvement in psoriatic patients with or without arthritis

Aim of the work: Measuring serum endocan level to determine its potential role in detecting subclinical cardiovascular involvement in psoriatic patients with or without arthritis. Patients and methods: This work included 14 psoriatic arthritis (PsA) patients, 14 psoriasis only (PsO) patients, and 14...

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Autores principales:	Salwa M.A. Ibrahim, Hala M.A. Sabah, Ahmed I. Eldesoky, Marwa Y. Soltan, Hebatallah A. Elshamy, Hala Abdulhady
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Endocan Tissue Doppler echocardiography Subclinical atherosclerosis Psoriasis Psoriatic arthritis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/15e4a297d8834e7aabe4d1efdc2dcdb2
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spelling	oai:doaj.org-article:15e4a297d8834e7aabe4d1efdc2dcdb22021-11-26T04:24:26ZRole of endothelial cell specific molecule-1 (endocan) and cardiac imaging in early detection of cardiac involvement in psoriatic patients with or without arthritis1110-116410.1016/j.ejr.2021.11.002https://doaj.org/article/15e4a297d8834e7aabe4d1efdc2dcdb22022-04-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1110116421000995https://doaj.org/toc/1110-1164Aim of the work: Measuring serum endocan level to determine its potential role in detecting subclinical cardiovascular involvement in psoriatic patients with or without arthritis. Patients and methods: This work included 14 psoriatic arthritis (PsA) patients, 14 psoriasis only (PsO) patients, and 14 age and sex matched controls. The psoriasis area severity index was evaluated. Serum endocan level was measured, subclinical atherosclerosis was assessed using brachial artery flow-mediated vasodilation (FMD), and echocardiography: standard and tissue Doppler imaging (TDI) was performed. Results: The mean age of PsA patients was 38.3 ± 9.9 years and for PsO was 37.9 ± 8 years. They were 3 males and 11 females in both groups with a comparable psoriasis duration (11 ± 4.9 vs 8 ± 6.3 years; p = 0.17). PsA patients had significantly increased endocan level (618 ± 227.8 ng/L) compared to those with PsO or controls (359 ± 185.7 and 130.6 ± 38.2 ng/L respectively; p < 0.001). 4 (28.6%) PsA patients, 1 (7.1%) PsO patient and none of the controls had FMD abnormality. TDI revealed early diastolic mitral annular motion velocity (E') abnormality in 5 (35.7%) PsA patients. In PsA patients, endocan level was significantly elevated in patients with FMD or E' abnormality compared to those without (p = 0.01 and p = 0.001, respectively). Serum endocan significantly negatively correlated with FMD and E' in psoriatic patients. Serum endocan significantly detected FMD and E' abnormalities in psoriatic patients (p = 0.002 and p = 0.001, respectively). Conclusion: Subclinical cardiovascular involvement was evident among psoriatic patients, particularly those with arthritis. Serum endocan is a promising endothelial biomarker for detecting subclinical atherosclerosis and preclinical cardiac dysfunction in psoriatic patients.Salwa M.A. IbrahimHala M.A. SabahAhmed I. EldesokyMarwa Y. SoltanHebatallah A. ElshamyHala AbdulhadyElsevierarticleEndocanTissue Doppler echocardiographySubclinical atherosclerosisPsoriasisPsoriatic arthritisImmunologic diseases. AllergyRC581-607ENEgyptian Rheumatologist, Vol 44, Iss 2, Pp 159-164 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Endocan Tissue Doppler echocardiography Subclinical atherosclerosis Psoriasis Psoriatic arthritis Immunologic diseases. Allergy RC581-607
spellingShingle	Endocan Tissue Doppler echocardiography Subclinical atherosclerosis Psoriasis Psoriatic arthritis Immunologic diseases. Allergy RC581-607 Salwa M.A. Ibrahim Hala M.A. Sabah Ahmed I. Eldesoky Marwa Y. Soltan Hebatallah A. Elshamy Hala Abdulhady Role of endothelial cell specific molecule-1 (endocan) and cardiac imaging in early detection of cardiac involvement in psoriatic patients with or without arthritis
description	Aim of the work: Measuring serum endocan level to determine its potential role in detecting subclinical cardiovascular involvement in psoriatic patients with or without arthritis. Patients and methods: This work included 14 psoriatic arthritis (PsA) patients, 14 psoriasis only (PsO) patients, and 14 age and sex matched controls. The psoriasis area severity index was evaluated. Serum endocan level was measured, subclinical atherosclerosis was assessed using brachial artery flow-mediated vasodilation (FMD), and echocardiography: standard and tissue Doppler imaging (TDI) was performed. Results: The mean age of PsA patients was 38.3 ± 9.9 years and for PsO was 37.9 ± 8 years. They were 3 males and 11 females in both groups with a comparable psoriasis duration (11 ± 4.9 vs 8 ± 6.3 years; p = 0.17). PsA patients had significantly increased endocan level (618 ± 227.8 ng/L) compared to those with PsO or controls (359 ± 185.7 and 130.6 ± 38.2 ng/L respectively; p < 0.001). 4 (28.6%) PsA patients, 1 (7.1%) PsO patient and none of the controls had FMD abnormality. TDI revealed early diastolic mitral annular motion velocity (E') abnormality in 5 (35.7%) PsA patients. In PsA patients, endocan level was significantly elevated in patients with FMD or E' abnormality compared to those without (p = 0.01 and p = 0.001, respectively). Serum endocan significantly negatively correlated with FMD and E' in psoriatic patients. Serum endocan significantly detected FMD and E' abnormalities in psoriatic patients (p = 0.002 and p = 0.001, respectively). Conclusion: Subclinical cardiovascular involvement was evident among psoriatic patients, particularly those with arthritis. Serum endocan is a promising endothelial biomarker for detecting subclinical atherosclerosis and preclinical cardiac dysfunction in psoriatic patients.
format	article
author	Salwa M.A. Ibrahim Hala M.A. Sabah Ahmed I. Eldesoky Marwa Y. Soltan Hebatallah A. Elshamy Hala Abdulhady
author_facet	Salwa M.A. Ibrahim Hala M.A. Sabah Ahmed I. Eldesoky Marwa Y. Soltan Hebatallah A. Elshamy Hala Abdulhady
author_sort	Salwa M.A. Ibrahim
title	Role of endothelial cell specific molecule-1 (endocan) and cardiac imaging in early detection of cardiac involvement in psoriatic patients with or without arthritis
title_short	Role of endothelial cell specific molecule-1 (endocan) and cardiac imaging in early detection of cardiac involvement in psoriatic patients with or without arthritis
title_full	Role of endothelial cell specific molecule-1 (endocan) and cardiac imaging in early detection of cardiac involvement in psoriatic patients with or without arthritis
title_fullStr	Role of endothelial cell specific molecule-1 (endocan) and cardiac imaging in early detection of cardiac involvement in psoriatic patients with or without arthritis
title_full_unstemmed	Role of endothelial cell specific molecule-1 (endocan) and cardiac imaging in early detection of cardiac involvement in psoriatic patients with or without arthritis
title_sort	role of endothelial cell specific molecule-1 (endocan) and cardiac imaging in early detection of cardiac involvement in psoriatic patients with or without arthritis
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/15e4a297d8834e7aabe4d1efdc2dcdb2
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Role of endothelial cell specific molecule-1 (endocan) and cardiac imaging in early detection of cardiac involvement in psoriatic patients with or without arthritis

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