Robust detection of translocations in lymphoma FFPE samples using targeted locus capture-based sequencing

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Robust detection of translocations in lymphoma FFPE samples using targeted locus capture-based sequencing

Preservation of cancer biopsies by FFPE introduces DNA fragmentation, hindering analysis of rearrangements. Here the authors introduce FFPE Targeted Locus Capture for identification of translocations in preserved samples.

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Détails bibliographiques
Auteurs principaux:	Amin Allahyar, Mark Pieterse, Joost Swennenhuis, G. Tjitske Los-de Vries, Mehmet Yilmaz, Roos Leguit, Ruud W. J. Meijers, Robert van der Geize, Joost Vermaat, Arjen Cleven, Tom van Wezel, Arjan Diepstra, Léon C. van Kempen, Nathalie J. Hijmering, Phylicia Stathi, Milan Sharma, Adrien S. J. Melquiond, Paula J. P. de Vree, Marjon J. A. M. Verstegen, Peter H. L. Krijger, Karima Hajo, Marieke Simonis, Agata Rakszewska, Max van Min, Daphne de Jong, Bauke Ylstra, Harma Feitsma, Erik Splinter, Wouter de Laat
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/15e52e7d12f34aa7b62f485085760e59
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Résumé:	Preservation of cancer biopsies by FFPE introduces DNA fragmentation, hindering analysis of rearrangements. Here the authors introduce FFPE Targeted Locus Capture for identification of translocations in preserved samples.