Everything in Moderation: Investigating the U-Shaped Link Between HDL Cholesterol and Adverse Outcomes

Despite historical evidence suggesting an inverse association between HDL cholesterol (HDL-C) and adverse cardiovascular events, pharmacological efforts to increase HDL-C and improve outcomes have not been successful. Recently, a U-shaped association between HDL-C and adverse events has been demonst...

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Autores principales:	Marc P Allard-Ratick, Pratik B Sandesara, Arshed A Quyyumi, Laurence S Sperling
Formato:	article
Lenguaje:	EN
Publicado:	Radcliffe Medical Media 2019
Materias:	Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/15e6a744a1e04d9aba20f49f6b741c29
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spelling	oai:doaj.org-article:15e6a744a1e04d9aba20f49f6b741c292021-12-04T16:01:05ZEverything in Moderation: Investigating the U-Shaped Link Between HDL Cholesterol and Adverse Outcomes10.15420/usc.2019.3.21758-390X1758-3896https://doaj.org/article/15e6a744a1e04d9aba20f49f6b741c292019-01-01T00:00:00Zhttps://www.uscjournal.com/articles/u-shaped-link-between-hdl-cholesterolhttps://doaj.org/toc/1758-3896https://doaj.org/toc/1758-390XDespite historical evidence suggesting an inverse association between HDL cholesterol (HDL-C) and adverse cardiovascular events, pharmacological efforts to increase HDL-C and improve outcomes have not been successful. Recently, a U-shaped association between HDL-C and adverse events has been demonstrated in several population cohorts, further complicating our understanding of the clinical significance of HDL. Potential explanations for this finding include genetic mutations linked to very high HDL-C, impaired HDL function at high HDL-C levels, and residual confounding. However, our understanding of this association remains premature and needs further investigation.Marc P Allard-RatickPratik B SandesaraArshed A QuyyumiLaurence S SperlingRadcliffe Medical MediaarticleDiseases of the circulatory (Cardiovascular) systemRC666-701ENUS Cardiology Review , Vol 13, Iss 1, Pp 49-53 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Diseases of the circulatory (Cardiovascular) system RC666-701 Marc P Allard-Ratick Pratik B Sandesara Arshed A Quyyumi Laurence S Sperling Everything in Moderation: Investigating the U-Shaped Link Between HDL Cholesterol and Adverse Outcomes
description	Despite historical evidence suggesting an inverse association between HDL cholesterol (HDL-C) and adverse cardiovascular events, pharmacological efforts to increase HDL-C and improve outcomes have not been successful. Recently, a U-shaped association between HDL-C and adverse events has been demonstrated in several population cohorts, further complicating our understanding of the clinical significance of HDL. Potential explanations for this finding include genetic mutations linked to very high HDL-C, impaired HDL function at high HDL-C levels, and residual confounding. However, our understanding of this association remains premature and needs further investigation.
format	article
author	Marc P Allard-Ratick Pratik B Sandesara Arshed A Quyyumi Laurence S Sperling
author_facet	Marc P Allard-Ratick Pratik B Sandesara Arshed A Quyyumi Laurence S Sperling
author_sort	Marc P Allard-Ratick
title	Everything in Moderation: Investigating the U-Shaped Link Between HDL Cholesterol and Adverse Outcomes
title_short	Everything in Moderation: Investigating the U-Shaped Link Between HDL Cholesterol and Adverse Outcomes
title_full	Everything in Moderation: Investigating the U-Shaped Link Between HDL Cholesterol and Adverse Outcomes
title_fullStr	Everything in Moderation: Investigating the U-Shaped Link Between HDL Cholesterol and Adverse Outcomes
title_full_unstemmed	Everything in Moderation: Investigating the U-Shaped Link Between HDL Cholesterol and Adverse Outcomes
title_sort	everything in moderation: investigating the u-shaped link between hdl cholesterol and adverse outcomes
publisher	Radcliffe Medical Media
publishDate	2019
url	https://doaj.org/article/15e6a744a1e04d9aba20f49f6b741c29
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Everything in Moderation: Investigating the U-Shaped Link Between HDL Cholesterol and Adverse Outcomes

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