Sex and age bias viral burden and interferon responses during SARS-CoV-2 infection in ferrets

Abstract SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) hospitalizations and deaths disportionally affect males and older ages. Here we investigated the impact of male sex and age comparing sex-matched or age-matched ferrets infected with SARS-CoV-2. Differences in temperature regulati...

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Autores principales:	Magen E. Francis, Brian Richardson, Una Goncin, Mara McNeil, Melissa Rioux, Mary K. Foley, Anni Ge, Roger D. Pechous, Jason Kindrachuk, Cheryl M. Cameron, Christopher Richardson, Jocelyne Lew, Steven Machtaler, Mark J. Cameron, Volker Gerdts, Darryl Falzarano, Alyson A. Kelvin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/15e6c94b4d0e4acf8d219088b5bbce54
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spelling	oai:doaj.org-article:15e6c94b4d0e4acf8d219088b5bbce542021-12-02T18:30:46ZSex and age bias viral burden and interferon responses during SARS-CoV-2 infection in ferrets10.1038/s41598-021-93855-92045-2322https://doaj.org/article/15e6c94b4d0e4acf8d219088b5bbce542021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93855-9https://doaj.org/toc/2045-2322Abstract SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) hospitalizations and deaths disportionally affect males and older ages. Here we investigated the impact of male sex and age comparing sex-matched or age-matched ferrets infected with SARS-CoV-2. Differences in temperature regulation was identified for male ferrets which was accompanied by prolonged viral replication in the upper respiratory tract after infection. Gene expression analysis of the nasal turbinates indicated that 1-year-old female ferrets had significant increases in interferon response genes post infection which were delayed in males. These results provide insight into COVID-19 and suggests that older males may play a role in viral transmission due to decreased antiviral responses.Magen E. FrancisBrian RichardsonUna GoncinMara McNeilMelissa RiouxMary K. FoleyAnni GeRoger D. PechousJason KindrachukCheryl M. CameronChristopher RichardsonJocelyne LewSteven MachtalerMark J. CameronVolker GerdtsDarryl FalzaranoAlyson A. KelvinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Magen E. Francis Brian Richardson Una Goncin Mara McNeil Melissa Rioux Mary K. Foley Anni Ge Roger D. Pechous Jason Kindrachuk Cheryl M. Cameron Christopher Richardson Jocelyne Lew Steven Machtaler Mark J. Cameron Volker Gerdts Darryl Falzarano Alyson A. Kelvin Sex and age bias viral burden and interferon responses during SARS-CoV-2 infection in ferrets
description	Abstract SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) hospitalizations and deaths disportionally affect males and older ages. Here we investigated the impact of male sex and age comparing sex-matched or age-matched ferrets infected with SARS-CoV-2. Differences in temperature regulation was identified for male ferrets which was accompanied by prolonged viral replication in the upper respiratory tract after infection. Gene expression analysis of the nasal turbinates indicated that 1-year-old female ferrets had significant increases in interferon response genes post infection which were delayed in males. These results provide insight into COVID-19 and suggests that older males may play a role in viral transmission due to decreased antiviral responses.
format	article
author	Magen E. Francis Brian Richardson Una Goncin Mara McNeil Melissa Rioux Mary K. Foley Anni Ge Roger D. Pechous Jason Kindrachuk Cheryl M. Cameron Christopher Richardson Jocelyne Lew Steven Machtaler Mark J. Cameron Volker Gerdts Darryl Falzarano Alyson A. Kelvin
author_facet	Magen E. Francis Brian Richardson Una Goncin Mara McNeil Melissa Rioux Mary K. Foley Anni Ge Roger D. Pechous Jason Kindrachuk Cheryl M. Cameron Christopher Richardson Jocelyne Lew Steven Machtaler Mark J. Cameron Volker Gerdts Darryl Falzarano Alyson A. Kelvin
author_sort	Magen E. Francis
title	Sex and age bias viral burden and interferon responses during SARS-CoV-2 infection in ferrets
title_short	Sex and age bias viral burden and interferon responses during SARS-CoV-2 infection in ferrets
title_full	Sex and age bias viral burden and interferon responses during SARS-CoV-2 infection in ferrets
title_fullStr	Sex and age bias viral burden and interferon responses during SARS-CoV-2 infection in ferrets
title_full_unstemmed	Sex and age bias viral burden and interferon responses during SARS-CoV-2 infection in ferrets
title_sort	sex and age bias viral burden and interferon responses during sars-cov-2 infection in ferrets
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/15e6c94b4d0e4acf8d219088b5bbce54
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Sex and age bias viral burden and interferon responses during SARS-CoV-2 infection in ferrets

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