Effect of relative social rank within a social hierarchy on neural activation in response to familiar or unfamiliar social signals

Abstract Competent social functioning of group-living species relies on the ability of individuals to detect and utilize conspecific social cues to guide behavior. Previous studies have identified numerous brain regions involved in processing these external cues, collectively referred to as the Soci...

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Autores principales:	Won Lee, Hollie N. Dowd, Cyrus Nikain, Madeleine F. Dwortz, Eilene D. Yang, James P. Curley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/15e77ac786a24a04a11be89d06f08a77
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spelling	oai:doaj.org-article:15e77ac786a24a04a11be89d06f08a772021-12-02T14:06:57ZEffect of relative social rank within a social hierarchy on neural activation in response to familiar or unfamiliar social signals10.1038/s41598-021-82255-82045-2322https://doaj.org/article/15e77ac786a24a04a11be89d06f08a772021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82255-8https://doaj.org/toc/2045-2322Abstract Competent social functioning of group-living species relies on the ability of individuals to detect and utilize conspecific social cues to guide behavior. Previous studies have identified numerous brain regions involved in processing these external cues, collectively referred to as the Social Decision-Making Network. However, how the brain encodes social information with respect to an individual’s social status has not been thoroughly examined. In mice, cues about an individual’s identity, including social status, are conveyed through urinary proteins. In this study, we assessed the neural cFos immunoreactivity in dominant and subordinate male mice exposed to familiar and unfamiliar dominant and subordinate male urine. The posteroventral medial amygdala was the only brain region that responded exclusively to dominant compared to subordinate male urine. In all other brain regions, including the VMH, PMv, and vlPAG, activity is modulated by a combination of odor familiarity and the social status of both the urine donor and the subject receiving the cue. We show that dominant subjects exhibit robust differential activity across different types of cues compared to subordinate subjects, suggesting that individuals perceive social cues differently depending on social experience. These data inform further investigation of neurobiological mechanisms underlying social-status related brain differences and behavior.Won LeeHollie N. DowdCyrus NikainMadeleine F. DwortzEilene D. YangJames P. CurleyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Won Lee Hollie N. Dowd Cyrus Nikain Madeleine F. Dwortz Eilene D. Yang James P. Curley Effect of relative social rank within a social hierarchy on neural activation in response to familiar or unfamiliar social signals
description	Abstract Competent social functioning of group-living species relies on the ability of individuals to detect and utilize conspecific social cues to guide behavior. Previous studies have identified numerous brain regions involved in processing these external cues, collectively referred to as the Social Decision-Making Network. However, how the brain encodes social information with respect to an individual’s social status has not been thoroughly examined. In mice, cues about an individual’s identity, including social status, are conveyed through urinary proteins. In this study, we assessed the neural cFos immunoreactivity in dominant and subordinate male mice exposed to familiar and unfamiliar dominant and subordinate male urine. The posteroventral medial amygdala was the only brain region that responded exclusively to dominant compared to subordinate male urine. In all other brain regions, including the VMH, PMv, and vlPAG, activity is modulated by a combination of odor familiarity and the social status of both the urine donor and the subject receiving the cue. We show that dominant subjects exhibit robust differential activity across different types of cues compared to subordinate subjects, suggesting that individuals perceive social cues differently depending on social experience. These data inform further investigation of neurobiological mechanisms underlying social-status related brain differences and behavior.
format	article
author	Won Lee Hollie N. Dowd Cyrus Nikain Madeleine F. Dwortz Eilene D. Yang James P. Curley
author_facet	Won Lee Hollie N. Dowd Cyrus Nikain Madeleine F. Dwortz Eilene D. Yang James P. Curley
author_sort	Won Lee
title	Effect of relative social rank within a social hierarchy on neural activation in response to familiar or unfamiliar social signals
title_short	Effect of relative social rank within a social hierarchy on neural activation in response to familiar or unfamiliar social signals
title_full	Effect of relative social rank within a social hierarchy on neural activation in response to familiar or unfamiliar social signals
title_fullStr	Effect of relative social rank within a social hierarchy on neural activation in response to familiar or unfamiliar social signals
title_full_unstemmed	Effect of relative social rank within a social hierarchy on neural activation in response to familiar or unfamiliar social signals
title_sort	effect of relative social rank within a social hierarchy on neural activation in response to familiar or unfamiliar social signals
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/15e77ac786a24a04a11be89d06f08a77
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Effect of relative social rank within a social hierarchy on neural activation in response to familiar or unfamiliar social signals

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