Mechanisms behind prometastatic changes induced by neoadjuvant chemotherapy in the breast cancer microenvironment

Vladimir M Perelmuter,1 Liubov A Tashireva,1 Olga E Savelieva,1 Evgeny V Denisov1,2, Evgeniya V Kaigorodova1,3, Marina V Zavyalova1,4, Nadezhda V Cherdyntseva1,21Cancer Research Institute, Tomsk National Research Medical Center, Tomsk 634050, Russia; 2Laboratory for Translational Cellular and Molecu...

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Autores principales:	Perelmuter VM, Tashireva LA, Savelieva OE, Denisov EV, Kaigorodova EV, Zavyalova MV, Cherdyntseva NV
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	breast cancer neoadjuvant chemotherapy microenvironment intravasation metastasis stress. Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/15e8582ac7994b57b31767453bc8961d
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spelling	oai:doaj.org-article:15e8582ac7994b57b31767453bc8961d2021-12-02T05:31:56ZMechanisms behind prometastatic changes induced by neoadjuvant chemotherapy in the breast cancer microenvironment1179-1314https://doaj.org/article/15e8582ac7994b57b31767453bc8961d2019-07-01T00:00:00Zhttps://www.dovepress.com/mechanisms-behind-prometastatic-changes-induced-by-neoadjuvant-chemoth-peer-reviewed-article-BCTThttps://doaj.org/toc/1179-1314Vladimir M Perelmuter,1 Liubov A Tashireva,1 Olga E Savelieva,1 Evgeny V Denisov1,2, Evgeniya V Kaigorodova1,3, Marina V Zavyalova1,4, Nadezhda V Cherdyntseva1,21Cancer Research Institute, Tomsk National Research Medical Center, Tomsk 634050, Russia; 2Laboratory for Translational Cellular and Molecular Biomedicine, Tomsk State University, Tomsk 634050, Russia; 3Department of Biochemistry, Siberian State Medical University, Tomsk 634055, Russia; 4Department of Pathological Anatomy, Siberian State Medical University, Tomsk 634055, RussiaAbstract: Chemotherapy, along with surgery and radiotherapy, is a key treatment option for malignant tumors. Neoadjuvant chemotherapy (NACT) reduces the tumor size and enables total tumor resection. In addition, NACT is believed to be more effective in destroying micrometastases than the same chemotherapy performed after surgery. To date, various NACT regimens have been tested and implemented, which provide a favorable outcome in primary tumors and reduce the risk of progression. However, there is increasing evidence of the NACT ability to increase the risk of cancer progression. This review discusses potential mechanisms by which NACT promotes distant metastasis of breast cancer through changes in the microenvironment of tumor cells. We describe prometastatic NACT-mediated changes in angiogenesis, immuno-inflammatory reactions in the stroma, intravasation, and amount of circulating tumor cells. The role of NACT-related cellular stress in cancer metastasis is also discussed.Keywords: breast cancer, neoadjuvant chemotherapy, microenvironment, intravasation, metastasis, stressPerelmuter VMTashireva LASavelieva OEDenisov EVKaigorodova EVZavyalova MVCherdyntseva NVDove Medical Pressarticlebreast cancerneoadjuvant chemotherapymicroenvironmentintravasationmetastasisstress.Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol Volume 11, Pp 209-219 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	breast cancer neoadjuvant chemotherapy microenvironment intravasation metastasis stress. Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	breast cancer neoadjuvant chemotherapy microenvironment intravasation metastasis stress. Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Perelmuter VM Tashireva LA Savelieva OE Denisov EV Kaigorodova EV Zavyalova MV Cherdyntseva NV Mechanisms behind prometastatic changes induced by neoadjuvant chemotherapy in the breast cancer microenvironment
description	Vladimir M Perelmuter,1 Liubov A Tashireva,1 Olga E Savelieva,1 Evgeny V Denisov1,2, Evgeniya V Kaigorodova1,3, Marina V Zavyalova1,4, Nadezhda V Cherdyntseva1,21Cancer Research Institute, Tomsk National Research Medical Center, Tomsk 634050, Russia; 2Laboratory for Translational Cellular and Molecular Biomedicine, Tomsk State University, Tomsk 634050, Russia; 3Department of Biochemistry, Siberian State Medical University, Tomsk 634055, Russia; 4Department of Pathological Anatomy, Siberian State Medical University, Tomsk 634055, RussiaAbstract: Chemotherapy, along with surgery and radiotherapy, is a key treatment option for malignant tumors. Neoadjuvant chemotherapy (NACT) reduces the tumor size and enables total tumor resection. In addition, NACT is believed to be more effective in destroying micrometastases than the same chemotherapy performed after surgery. To date, various NACT regimens have been tested and implemented, which provide a favorable outcome in primary tumors and reduce the risk of progression. However, there is increasing evidence of the NACT ability to increase the risk of cancer progression. This review discusses potential mechanisms by which NACT promotes distant metastasis of breast cancer through changes in the microenvironment of tumor cells. We describe prometastatic NACT-mediated changes in angiogenesis, immuno-inflammatory reactions in the stroma, intravasation, and amount of circulating tumor cells. The role of NACT-related cellular stress in cancer metastasis is also discussed.Keywords: breast cancer, neoadjuvant chemotherapy, microenvironment, intravasation, metastasis, stress
format	article
author	Perelmuter VM Tashireva LA Savelieva OE Denisov EV Kaigorodova EV Zavyalova MV Cherdyntseva NV
author_facet	Perelmuter VM Tashireva LA Savelieva OE Denisov EV Kaigorodova EV Zavyalova MV Cherdyntseva NV
author_sort	Perelmuter VM
title	Mechanisms behind prometastatic changes induced by neoadjuvant chemotherapy in the breast cancer microenvironment
title_short	Mechanisms behind prometastatic changes induced by neoadjuvant chemotherapy in the breast cancer microenvironment
title_full	Mechanisms behind prometastatic changes induced by neoadjuvant chemotherapy in the breast cancer microenvironment
title_fullStr	Mechanisms behind prometastatic changes induced by neoadjuvant chemotherapy in the breast cancer microenvironment
title_full_unstemmed	Mechanisms behind prometastatic changes induced by neoadjuvant chemotherapy in the breast cancer microenvironment
title_sort	mechanisms behind prometastatic changes induced by neoadjuvant chemotherapy in the breast cancer microenvironment
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/15e8582ac7994b57b31767453bc8961d
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Mechanisms behind prometastatic changes induced by neoadjuvant chemotherapy in the breast cancer microenvironment

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