Identification of early-onset photoreceptor degeneration in transgenic mouse models of Alzheimer's disease

Summary: Light sensitivity of the vertebrate retina relies on the integrity of photoreceptors, including rods and cones. Research in patients with Alzheimer's disease (AD) and in AD transgenic mice reports that accumulated amyloid-β (Aβ) plaques in the retina are toxic to retinal neurons. Moreo...

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Autores principales:	Jie Zhang, Feng Gao, Yuqian Ma, Tian Xue, Yong Shen
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Neuroscience Molecular neuroscience Cellular neuroscience Science Q
Acceso en línea:	https://doaj.org/article/15ec5dfbedae490ea3f8a47f22878215
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spelling	oai:doaj.org-article:15ec5dfbedae490ea3f8a47f228782152021-11-20T05:09:59ZIdentification of early-onset photoreceptor degeneration in transgenic mouse models of Alzheimer's disease2589-004210.1016/j.isci.2021.103327https://doaj.org/article/15ec5dfbedae490ea3f8a47f228782152021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589004221012967https://doaj.org/toc/2589-0042Summary: Light sensitivity of the vertebrate retina relies on the integrity of photoreceptors, including rods and cones. Research in patients with Alzheimer's disease (AD) and in AD transgenic mice reports that accumulated amyloid-β (Aβ) plaques in the retina are toxic to retinal neurons. Moreover, Aβ plaques are deposited around the rods and cones, yet photoreceptor anomalies remain unclear in AD. Here, we identify the progressive degeneration of rods and cones characterized by impaired expression of phototransduction proteins, morphological alterations, functional deficits, and even cell loss. Furthermore, we demonstrate that cell senescence and necroptosis were involved in rod degeneration. Importantly, using in vivo scotopic electroretinogram, we detected rod degeneration in early-stage AD transgenic mice before Aβ plaques were observed in the brain. Moreover, we demonstrate that rod degeneration was among the earliest AD retinal manifestations compared with other types of retinal neurons. Overall, our study is the first to identify and detect in vivo, early-onset photoreceptor degeneration in AD.Jie ZhangFeng GaoYuqian MaTian XueYong ShenElsevierarticleNeuroscienceMolecular neuroscienceCellular neuroscienceScienceQENiScience, Vol 24, Iss 11, Pp 103327- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neuroscience Molecular neuroscience Cellular neuroscience Science Q
spellingShingle	Neuroscience Molecular neuroscience Cellular neuroscience Science Q Jie Zhang Feng Gao Yuqian Ma Tian Xue Yong Shen Identification of early-onset photoreceptor degeneration in transgenic mouse models of Alzheimer's disease
description	Summary: Light sensitivity of the vertebrate retina relies on the integrity of photoreceptors, including rods and cones. Research in patients with Alzheimer's disease (AD) and in AD transgenic mice reports that accumulated amyloid-β (Aβ) plaques in the retina are toxic to retinal neurons. Moreover, Aβ plaques are deposited around the rods and cones, yet photoreceptor anomalies remain unclear in AD. Here, we identify the progressive degeneration of rods and cones characterized by impaired expression of phototransduction proteins, morphological alterations, functional deficits, and even cell loss. Furthermore, we demonstrate that cell senescence and necroptosis were involved in rod degeneration. Importantly, using in vivo scotopic electroretinogram, we detected rod degeneration in early-stage AD transgenic mice before Aβ plaques were observed in the brain. Moreover, we demonstrate that rod degeneration was among the earliest AD retinal manifestations compared with other types of retinal neurons. Overall, our study is the first to identify and detect in vivo, early-onset photoreceptor degeneration in AD.
format	article
author	Jie Zhang Feng Gao Yuqian Ma Tian Xue Yong Shen
author_facet	Jie Zhang Feng Gao Yuqian Ma Tian Xue Yong Shen
author_sort	Jie Zhang
title	Identification of early-onset photoreceptor degeneration in transgenic mouse models of Alzheimer's disease
title_short	Identification of early-onset photoreceptor degeneration in transgenic mouse models of Alzheimer's disease
title_full	Identification of early-onset photoreceptor degeneration in transgenic mouse models of Alzheimer's disease
title_fullStr	Identification of early-onset photoreceptor degeneration in transgenic mouse models of Alzheimer's disease
title_full_unstemmed	Identification of early-onset photoreceptor degeneration in transgenic mouse models of Alzheimer's disease
title_sort	identification of early-onset photoreceptor degeneration in transgenic mouse models of alzheimer's disease
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/15ec5dfbedae490ea3f8a47f22878215
work_keys_str_mv	AT jiezhang identificationofearlyonsetphotoreceptordegenerationintransgenicmousemodelsofalzheimersdisease AT fenggao identificationofearlyonsetphotoreceptordegenerationintransgenicmousemodelsofalzheimersdisease AT yuqianma identificationofearlyonsetphotoreceptordegenerationintransgenicmousemodelsofalzheimersdisease AT tianxue identificationofearlyonsetphotoreceptordegenerationintransgenicmousemodelsofalzheimersdisease AT yongshen identificationofearlyonsetphotoreceptordegenerationintransgenicmousemodelsofalzheimersdisease
_version_	1718419526564970496

Identification of early-onset photoreceptor degeneration in transgenic mouse models of Alzheimer's disease

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