Structure of Rap1b bound to talin reveals a pathway for triggering integrin activation

The transmembrane receptor integrin is activated by talin, but so far it has remained elusive how talin is recruited to the plasma membrane. Here, the authors identify the Rap1-mediated membrane-targeting mechanism for talin, present the Rap1b/talin-F0 structure and show that talin is a direct Rap1b...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Liang Zhu, Jun Yang, Thomas Bromberger, Ashley Holly, Fan Lu, Huan Liu, Kevin Sun, Sarah Klapproth, Jamila Hirbawi, Tatiana V. Byzova, Edward F. Plow, Markus Moser, Jun Qin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/15ed6742ffb34d9d884d48e64df0be10
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:15ed6742ffb34d9d884d48e64df0be10
record_format	dspace
spelling	oai:doaj.org-article:15ed6742ffb34d9d884d48e64df0be102021-12-02T14:41:18ZStructure of Rap1b bound to talin reveals a pathway for triggering integrin activation10.1038/s41467-017-01822-82041-1723https://doaj.org/article/15ed6742ffb34d9d884d48e64df0be102017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01822-8https://doaj.org/toc/2041-1723The transmembrane receptor integrin is activated by talin, but so far it has remained elusive how talin is recruited to the plasma membrane. Here, the authors identify the Rap1-mediated membrane-targeting mechanism for talin, present the Rap1b/talin-F0 structure and show that talin is a direct Rap1b effector.Liang ZhuJun YangThomas BrombergerAshley HollyFan LuHuan LiuKevin SunSarah KlapprothJamila HirbawiTatiana V. ByzovaEdward F. PlowMarkus MoserJun QinNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Liang Zhu Jun Yang Thomas Bromberger Ashley Holly Fan Lu Huan Liu Kevin Sun Sarah Klapproth Jamila Hirbawi Tatiana V. Byzova Edward F. Plow Markus Moser Jun Qin Structure of Rap1b bound to talin reveals a pathway for triggering integrin activation
description	The transmembrane receptor integrin is activated by talin, but so far it has remained elusive how talin is recruited to the plasma membrane. Here, the authors identify the Rap1-mediated membrane-targeting mechanism for talin, present the Rap1b/talin-F0 structure and show that talin is a direct Rap1b effector.
format	article
author	Liang Zhu Jun Yang Thomas Bromberger Ashley Holly Fan Lu Huan Liu Kevin Sun Sarah Klapproth Jamila Hirbawi Tatiana V. Byzova Edward F. Plow Markus Moser Jun Qin
author_facet	Liang Zhu Jun Yang Thomas Bromberger Ashley Holly Fan Lu Huan Liu Kevin Sun Sarah Klapproth Jamila Hirbawi Tatiana V. Byzova Edward F. Plow Markus Moser Jun Qin
author_sort	Liang Zhu
title	Structure of Rap1b bound to talin reveals a pathway for triggering integrin activation
title_short	Structure of Rap1b bound to talin reveals a pathway for triggering integrin activation
title_full	Structure of Rap1b bound to talin reveals a pathway for triggering integrin activation
title_fullStr	Structure of Rap1b bound to talin reveals a pathway for triggering integrin activation
title_full_unstemmed	Structure of Rap1b bound to talin reveals a pathway for triggering integrin activation
title_sort	structure of rap1b bound to talin reveals a pathway for triggering integrin activation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/15ed6742ffb34d9d884d48e64df0be10
work_keys_str_mv	AT liangzhu structureofrap1bboundtotalinrevealsapathwayfortriggeringintegrinactivation AT junyang structureofrap1bboundtotalinrevealsapathwayfortriggeringintegrinactivation AT thomasbromberger structureofrap1bboundtotalinrevealsapathwayfortriggeringintegrinactivation AT ashleyholly structureofrap1bboundtotalinrevealsapathwayfortriggeringintegrinactivation AT fanlu structureofrap1bboundtotalinrevealsapathwayfortriggeringintegrinactivation AT huanliu structureofrap1bboundtotalinrevealsapathwayfortriggeringintegrinactivation AT kevinsun structureofrap1bboundtotalinrevealsapathwayfortriggeringintegrinactivation AT sarahklapproth structureofrap1bboundtotalinrevealsapathwayfortriggeringintegrinactivation AT jamilahirbawi structureofrap1bboundtotalinrevealsapathwayfortriggeringintegrinactivation AT tatianavbyzova structureofrap1bboundtotalinrevealsapathwayfortriggeringintegrinactivation AT edwardfplow structureofrap1bboundtotalinrevealsapathwayfortriggeringintegrinactivation AT markusmoser structureofrap1bboundtotalinrevealsapathwayfortriggeringintegrinactivation AT junqin structureofrap1bboundtotalinrevealsapathwayfortriggeringintegrinactivation
_version_	1718389914723155968

Structure of Rap1b bound to talin reveals a pathway for triggering integrin activation

Ejemplares similares