Predictive features of persistent activity emergence in regular spiking and intrinsic bursting model neurons.

Proper functioning of working memory involves the expression of stimulus-selective persistent activity in pyramidal neurons of the prefrontal cortex (PFC), which refers to neural activity that persists for seconds beyond the end of the stimulus. The mechanisms which PFC pyramidal neurons use to disc...

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Autores principales:	Kyriaki Sidiropoulou, Panayiota Poirazi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/15f06c03fb984e3f85ea18736046a8dd
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spelling	oai:doaj.org-article:15f06c03fb984e3f85ea18736046a8dd2021-11-18T05:51:22ZPredictive features of persistent activity emergence in regular spiking and intrinsic bursting model neurons.1553-734X1553-735810.1371/journal.pcbi.1002489https://doaj.org/article/15f06c03fb984e3f85ea18736046a8dd2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22570601/pdf/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Proper functioning of working memory involves the expression of stimulus-selective persistent activity in pyramidal neurons of the prefrontal cortex (PFC), which refers to neural activity that persists for seconds beyond the end of the stimulus. The mechanisms which PFC pyramidal neurons use to discriminate between preferred vs. neutral inputs at the cellular level are largely unknown. Moreover, the presence of pyramidal cell subtypes with different firing patterns, such as regular spiking and intrinsic bursting, raises the question as to what their distinct role might be in persistent firing in the PFC. Here, we use a compartmental modeling approach to search for discriminatory features in the properties of incoming stimuli to a PFC pyramidal neuron and/or its response that signal which of these stimuli will result in persistent activity emergence. Furthermore, we use our modeling approach to study cell-type specific differences in persistent activity properties, via implementing a regular spiking (RS) and an intrinsic bursting (IB) model neuron. We identify synaptic location within the basal dendrites as a feature of stimulus selectivity. Specifically, persistent activity-inducing stimuli consist of activated synapses that are located more distally from the soma compared to non-inducing stimuli, in both model cells. In addition, the action potential (AP) latency and the first few inter-spike-intervals of the neuronal response can be used to reliably detect inducing vs. non-inducing inputs, suggesting a potential mechanism by which downstream neurons can rapidly decode the upcoming emergence of persistent activity. While the two model neurons did not differ in the coding features of persistent activity emergence, the properties of persistent activity, such as the firing pattern and the duration of temporally-restricted persistent activity were distinct. Collectively, our results pinpoint to specific features of the neuronal response to a given stimulus that code for its ability to induce persistent activity and predict differential roles of RS and IB neurons in persistent activity expression.Kyriaki SidiropoulouPanayiota PoiraziPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 8, Iss 4, p e1002489 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Kyriaki Sidiropoulou Panayiota Poirazi Predictive features of persistent activity emergence in regular spiking and intrinsic bursting model neurons.
description	Proper functioning of working memory involves the expression of stimulus-selective persistent activity in pyramidal neurons of the prefrontal cortex (PFC), which refers to neural activity that persists for seconds beyond the end of the stimulus. The mechanisms which PFC pyramidal neurons use to discriminate between preferred vs. neutral inputs at the cellular level are largely unknown. Moreover, the presence of pyramidal cell subtypes with different firing patterns, such as regular spiking and intrinsic bursting, raises the question as to what their distinct role might be in persistent firing in the PFC. Here, we use a compartmental modeling approach to search for discriminatory features in the properties of incoming stimuli to a PFC pyramidal neuron and/or its response that signal which of these stimuli will result in persistent activity emergence. Furthermore, we use our modeling approach to study cell-type specific differences in persistent activity properties, via implementing a regular spiking (RS) and an intrinsic bursting (IB) model neuron. We identify synaptic location within the basal dendrites as a feature of stimulus selectivity. Specifically, persistent activity-inducing stimuli consist of activated synapses that are located more distally from the soma compared to non-inducing stimuli, in both model cells. In addition, the action potential (AP) latency and the first few inter-spike-intervals of the neuronal response can be used to reliably detect inducing vs. non-inducing inputs, suggesting a potential mechanism by which downstream neurons can rapidly decode the upcoming emergence of persistent activity. While the two model neurons did not differ in the coding features of persistent activity emergence, the properties of persistent activity, such as the firing pattern and the duration of temporally-restricted persistent activity were distinct. Collectively, our results pinpoint to specific features of the neuronal response to a given stimulus that code for its ability to induce persistent activity and predict differential roles of RS and IB neurons in persistent activity expression.
format	article
author	Kyriaki Sidiropoulou Panayiota Poirazi
author_facet	Kyriaki Sidiropoulou Panayiota Poirazi
author_sort	Kyriaki Sidiropoulou
title	Predictive features of persistent activity emergence in regular spiking and intrinsic bursting model neurons.
title_short	Predictive features of persistent activity emergence in regular spiking and intrinsic bursting model neurons.
title_full	Predictive features of persistent activity emergence in regular spiking and intrinsic bursting model neurons.
title_fullStr	Predictive features of persistent activity emergence in regular spiking and intrinsic bursting model neurons.
title_full_unstemmed	Predictive features of persistent activity emergence in regular spiking and intrinsic bursting model neurons.
title_sort	predictive features of persistent activity emergence in regular spiking and intrinsic bursting model neurons.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/15f06c03fb984e3f85ea18736046a8dd
work_keys_str_mv	AT kyriakisidiropoulou predictivefeaturesofpersistentactivityemergenceinregularspikingandintrinsicburstingmodelneurons AT panayiotapoirazi predictivefeaturesofpersistentactivityemergenceinregularspikingandintrinsicburstingmodelneurons
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Predictive features of persistent activity emergence in regular spiking and intrinsic bursting model neurons.

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